Impact of maternal HIV co-infection on the vertical transmission of Hepatitis C virus: a meta-analysis.

Post Date: 
2007-04-15
Publication: 
Clinical Infectious Diseases
Summary: 

Background: Observational studies suggest that maternal human immunodeficiency virus (HIV)-hepatitis C virus (HCV) coinfection is associated with increased odds of vertical HCV transmission. We performed a meta-analysis to summarize current evidence.


 


Methods: We systematically searched for relevant articles published during the period from January 1992 through July 2006 and independently abstracted articles that met our inclusion criteria. Under a random effects model, we calculated the pooled odds ratio for vertical HCV transmission according to maternal HIV-HCV coinfection status and performed sensitivity analyses.

Citation: 
Polis C, Shah S, Johnson K, Gupta A. Impact of maternal HIV co-infection on the vertical transmission of Hepatitis C virus: a meta-analysis. Clin Infect Dis. 2007 Apr 15; 44(8) 1123-31. doi: 10.1086/512815.
Staff: 
Amita Gupta, MD, MHS
Collaborators: 
  • Department of Population, Family and Reproductive Health, JOhns Hopkins Bloomberg School of Public Health, Baltimore, MD
  • Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
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