Study Results for IMPAACT P1078 Presented at CROI 2018

... Primary analyses of the study, presented by Amita Gupta on behalf of the P1078 protocol team, indicated that the study was not able to conclude that antepartum IPT is as safe as postpartum IPT, in part because endpoints among mothers were higher than expected in both arms. There were no statistically significant differences between arms in the number of mothers or infants who had grade 3 or higher adverse events, in the number of mothers who had hepatotoxicity events from any cause, or in the number of mothers or infants who died during the study. Incidence of tuberculosis for mothers and infants was low and comparable between arms ...