Vidya Mave, MD, MPH

Pune, India

Role:

Director

Associate Professor

Vidya Mave

Dr. Mave is Co-Director of the Center for Infectious Diseases in India and Associate Professor at the Johns Hopkins School of Medicine. She is also Director and Clinical Research Site (CRS) Leader of the Johns Hopkins University Baltimore-India Clinical Trials Unit (JHUBI-CTU) in Pune, India. The CTU is a collaborative research partnership between BJGMC in Pune, India and Johns Hopkins School of Medicine that is part of the world’s largest HIV therapeutic trial networks (the AIDS Clinical Trials Group [ACTG] and the International Maternal Pediatric and Adolescent AIDS Clinical Trial Network [IMPAACT]).

Dr. Mave has more than 20 years of experience in clinical practice, education, and research in infectious diseases and has published more than 100 peer-reviewed research articles. Following a short tenure as Assistant Professor of Infectious Diseases at Tulane University School of Medicine, Dr. Mave joined the Johns Hopkins in 2010. She now leads and coordinates all clinical research activities for the JHUBI-CTU, which conducts phase I, II, and III clinical trials of therapeutic drug interventions for HIV and co-morbid infections, including TB and hepatitis, in adults (including pregnant women) and children. Dr. Mave’s research interests include TB clinical trials (of vaccines and new and re-purposed drugs) to optimize treatment outcomes; comorbidities (including diabetes, HIV), and the use of novel tools (Hair PK, whole genome sequencing, host biomarkers) to study TB treatment outcomes; and assessing best implementation strategies in programmatic settings. In addition, Dr. Mave has mentored more than 20 pre- and postdoctoral trainees from Johns Hopkins.

Dr. Mave received an MD in medicine from Karnatak University, Dharwad, India, and an MPH from Tulane University. She completed her internal medicine training at St. Barnabas Hospital in New York, followed by a post-doctoral fellowship in infectious diseases at Tulane University and Long Island Jewish Medical Center. Dr. Mave is board certified in internal medicine and infectious diseases by the American Board of Internal Medicine.

Leadership

Protocol Chair, A 5384: A Phase II, Randomized, Open-Label Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents with Tuberculous Meningitis: Improved Management with Antimicrobial AGents Isoniazid rifampiciN LinEzolid for TBM (IMAGINE-TBM)
Co-Vice Chair, ACTG Tuberculosis Transformative Science Group
Protocol Vice Chair, A5397/HVTN 603: A Phase 2A/2B Study Evaluating Safety and Immunogenicity of Therapeutic ID93 + GLA-SE Vaccination in Participants with Rifampicin-susceptible Pulmonary TB.

Publications

Maternal syphilis: An independent risk factor for mother to infant human immunodeficiency virus transmission

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2017-06-15

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Sexually Transmitted Diseases

Abstract Syphilis is associated with increased human immunodeficiency virus acquisition and sexual transmission; we examined impact on human immunodeficiency virus mother-to-child transmission among mother-infant pairs enrolled in the India Six-Week Extended-Dose Nevirapine study...

Tuberculosis screening among persons with diabetes mellitus in Pune, India

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2017-06-02

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BMC Infectious Diseases

Background: Diabetes mellitus (DM) increases tuberculosis (TB) risk, and there is increasing concern over the public health implications of the convergence of these two epidemics. Screening for TB among people with DM is now recommended in India. Methods: People with DM seeking...

High burden of antimicrobial resistance and mortality among adults and children with community-onset bacterial infections in India

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2017-04-15

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Journal of Infectious Diseases

Of 133 isolates from 115 patients, 50% were multi-drug resistant; of 33 isolates tested for carbapenem susceptibility, 36% were resistant.

Novel interferon-gamma assays for diagnosing tuberculosis in young children in India

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2017-04-01

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International Journal of Tuberculosis and Lung Disease

Setting: The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used as supportive evidence to diagnose active tuberculosis (TB). Novel IGRAs could improve diagnosis, but data are lacking in young children. Design: Children (age 5 years or...

High prevalence of cryptococcal antigenaemia amongst asymptomatic advanced HIV patients in Pune, India

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2017-03-21

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Indian Journal of Medical Microbiology

Methods : A prospective study was conducted in a large public sector ART centre and the inpatient wards of Sassoon Hospital, Pune, India. All consenting patients> 18 years of age with CD4 count <100 cells/mm3 were screened for CrAg by latex agglutination assay. Those with positive CrAg...

Efficacy of six-week extended-dose nevirapine varies by infant birth weight with greatest relative efficacy in low birth weight infants

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2016-09-30

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PLOS One

Low birth weight (LBW), defined by the World Health Organization (WHO) as birth weight less than 2500 g, is a significant public health issue in resource-limited settings, particularly in Sub Saharan Africa and South Asia where the estimated annual incidence is 14% and 28–31%, respectively,...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

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2016-07-01

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Journal of Infectious Diseases

Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the...

Quantitative IFN-y,IL-2 response and latent tuberculosis test discordance in HIV-infected pregnant women

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2016-06-15

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American Journal of Respiratory and Critical Care Medicine

Rationale: Pregnant women with latent tuberculosis infection (LTBI) are at high risk for development of TB, especially if infected with HIV. Objectives: To assess the performance of LTBI tests in pregnant and postpartum women infected with HIV, investigate the...

Isoniazid hair concentrations in children with tuberculosis: a proof of concept study

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2016-06-01

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International Journal of Tuberculosis and Lung Disease

Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged <12 years initiated on...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

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2016-04-01

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The Journal of Infectious Diseases

Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the...

Tuberculosis risk among medical trainees, Pune, India

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2016-03-22

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Emerging Infectious Diseases

During 2012–2013, at a public hospital in Pune, India, 26 (3.9%) cases of tuberculosis were reported among 662 medical trainees, representing an estimated incidence of 3,279 cases/100,000 person-years. Three of these infections were isoniazid-resistant, 1 was multidrug-resistant, and 1...

Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial

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2016-03-19

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The Lancet

Background: Mortality within the first 6 months after initiating antiretroviral therapy is common in resource-limited settings and is often due to tuberculosis in patients with advanced HIV disease. Isoniazid preventive therapy is recommended in HIV-positive adults, but subclinical...

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH): protocol for a multicentric prospective observational study

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2016-02-25

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BMJ Open

Introduction: Tuberculosis disease (TB) remains an important global health threat. An evidence-based response, tailored to local disease epidemiology in high-burden countries, is key to controlling the global TB epidemic. Reliable surrogate biomarkers that predict key active disease and...

Soluble CD14: An independent biomarker for risk of HIV mother-to-child transmission in setting of pre- and post-exposure antiretroviral prophylaxis

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2015-10-06

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The Journal of Infectious Diseases

Elevated soluble CD14 (sCD14) concentrations, a marker of monocyte activation, predicts adverse outcomes in human immunodeficiency virus (HIV)-infected adults. To examine the association of sCD14 concentrations with the risk of mother-to-child transmission (MTCT) of HIV, we nested a case-...

Mother and child both matter: reconceptualizing the prevention of mother-to-child transmission care continuum

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2015-09-08

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Current Opinion in HIV and AIDS

Purpose of review: To propose a prevention of mother-to-child transmission (PMTCT) care continuum that defines the programmatic steps necessary to provide HIV care to the HIV-infected pregnant woman and her infant during the risk period for HIV transmission. Recent...

Contraceptive use and factors associated with postpartum surgical sterilization among HIV-infected women in Pune, India

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2015-08-21

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Journal of HIV/AIDS & Social Services

The authors desire to better understand contraceptive practices and factors associated with surgical tubal ligation (STL) among HIV-infected women. Secondary data were obtained from HIV-infected women enrolled in a National Institutes of Health–funded clinical trial assessing the efficacy of...

Vitamin D deficiency and risk of postpartum tuberculosis among HIV-infected breastfeeding mothers in India

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2015-03-15

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International Journal of Tuberculosis and Lung Disease

Some studies have associated low vitamin D levels with the risk of tuberculosis (TB), but its association in human immunodeficiency virus (HIV) infected mothers in a TB-endemic region has not been well studied. We conducted a nested 1:2 case-control study among HIV-infected mothers in western...

Source case investigation for children with TB disease in Pune, India

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2014-08-27

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Tuberculosis Research and Treatment

Setting. Contact tracing is broadly encouraged for tuberculosis (TB) control. In many high-burden countries, however, little effort is made to identify contacts of newly diagnosed TB patients. This failure puts children, many of whom live in poor crowded communities, at special risk. ...

Impact of maternal hepatitis B virus coinfection on mother-to-child transmission of HIV

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2014-07-15

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HIV Medicine

Objectives: Despite high hepatitis B virus (HBV) endemicity in various resource-limited settings (RLSs), the impact of maternal HIV/HBV coinfection on infant health outcomes has not been defined. We aimed to assess the prevalence of HBV coinfection among HIV-infected pregnant women and its...

Blood stream infections

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2014-07-01

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BioMed Research International

Blood stream infection (BSI) is one of the most devastating preventable complications in Critical Care Units. It has far-reaching consequences resulting in prolonged length of hospital-stay, high costs to the individual and exchequer, and, in many instances, loss of life. Although exact rates...

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