India

With a population of more than one billion, India is the second largest country in the world, represents 16% of the global population, and the national average for life expectancy is only 65 years. India leads the world in the largest absolute burden of TB, ranks third for HIV (behind South Africa and Nigeria), and ranks second for diabetes. The country receives funding to support HIV/AIDS prevention, treatment and care programs under the US President's Emergency Plan for AIDS Relief (PEPFAR).

Our Indo-JHU Clinical Research Partnership is dedicated to reversing poor patient outcomes. With operations based in Pune, our extensive research portfolio is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya Mave, Dr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and, in addition to our memberships in consortia with many esteemed Indian research institutions, we have formal agreements with:

Byramjee Jeejeebhoy Government Medical College, and Sassoon General Hospital (BJGMC). Pune, India
DY Patil Medical College, Hospital and Research Center. Pune, India
National Institute for Research in Tuberculosis. Chennai, India
PD Hinduja Hospital and Medical Group. Mumbai, India
Medanta The Medicity. Gurgaon, India
KEM Hospital. Pune, India
Bharati Vidyapeeth Medical College. Pune, India

CCGHE WORK IN INDIA

Publications

Detection of microbial translocation in HIV and SIV infection using the limulus amebocyte lysate assay is masked by serum and plasma

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2012-08-01

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PLOS One

Objective: Microbial translocation (MT) is thought to be a major contributor to the pathogenesis of HIV-related immune activation, and circulating lipopolysaccharide (LPS) from Gram-negative bacteria is the principle measurement of this process. However, related research has been impeded by...

Authors’ response to Hanrahan et al CID article

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2012-05-15

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Clinical Infectious Diseases

Reply to letter

Predictors of mortality in hospitalized children with pandemic H1N1 influenza 2009 in Pune, India

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2012-04-15

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Indian Journal of Pediatrics

Objective: To analyse the factors associated with increased mortality among Indian Children with H1N1. Methods: Data were abstracted from available hospital records of children less than 12 y of age, who were admitted to Sassoon General Hospital in Pune, India, with...

Determination of a reference interval in a population

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2012-02-01

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National Medical Journal of India

The reference interval is the most widely used medical decision-making tool that separates healthy from diseased individuals. We briefly discuss the methods used to determine reference interval and its limitations.

Global health education for medical students: New learning opportunities and strategies

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2012-01-17

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Medical Teacher

Background: A new course was offered to introduce basic global health concepts to all first year Johns Hopkins medical students, that took advantage of new distance learning capacity to connect medical students in Baltimore with students and faculty in Uganda, Ethiopia, Pakistan and India...

Sexually transmitted infections and risk behaviors among transgender persons (Hijras) of Pune, India

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2012-01-15

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Journal of Acquired Immune Deficiency Syndromes

Background: The objectives of this cross-sectional study were to determine the prevalence of HIV and sexually transmitted infections (STI) in Hijras (self-identified transgenders of South Asia), study associated risk factors, and compare the prevalence with that in heterosexual men and men...

Impact of maternal human immunodeficiency virus infection on pregnancy and birth outcomes in Pune, India

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2011-12-15

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AIDS Care

Little is known about birth outcomes for HIV-infected women in India. We examine maternal and neonatal birth outcomes in HIV-infected women within the context of enhanced pre-natal care associated with a randomized clinical trial conducted in Pune, India. Birth outcomes of 212 HIV-infected...

Symptom screening among HIV-infected pregnant women is acceptable and has high negative predictive value for active tuberculosis

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2011-11-15

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Clinical Infectious Diseases

Symptom screening is a recommended component of intensified case-finding (ICF) for pulmonary tuberculosis (TB) among HIV-infected individuals. Symptomatic individuals are further investigated to either exclude or diagnose pulmonary TB, thus reducing the number of individuals requiring costly...

Prevention of HIV-1 infection with early antiretroviral therapy

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2011-08-11

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New England Journal of Medicine

Background: Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. Methods: In nine countries, we enrolled 1763 couples in which one partner was HIV-1–positive and the other was HIV-1–negative; 54...

High rates of all-cause and gastroenteritis-related hospitalization morbidity and mortality among HIV-exposed Indian infants

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2011-07-15

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BMC Infectious Diseases

Background: HIV-infected and HIV-exposed, uninfected infants experience a high burden of infectious morbidity and mortality. Hospitalization is an important metric for morbidity and is associated with high mortality, yet, little is known about rates and causes of hospitalization among these...

A comparison of online versus on-site training in health research methodology: A randomized study

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2011-06-17

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BMC Medical Education

Background: Distance learning may be useful for building health research capacity. However, evidence that it can improve knowledge and skills in health research, particularly in resource-poor settings, is limited. We compared the impact and acceptability of teaching two distinct content areas...

Early childhood growth among Mahadev Koli tribes of Maharashtra

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2011-06-01

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Voice of Intellectual Man

The present study aims “to study the growth status of the children of age group 0 to 5 years of Mahadev koli”. This cross-sectional study focuses on growth of children of age group 0 to 5 years in Ambegaon Taluka, Pune district, Maharashtra. Using De-facto population, 110 Mahadev Koli- 51 girls and...

Mortality in HIV infected individuals in Pune, India

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2011-04-15

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Indian Journal of Medical Research

Background & Objectives: With the presence of HIV epidemic for more than two decades in India, rise in the number of HIV related deaths is expected. Data on mortality in HIV infected individuals from prospective studies are scanty in India. We report here data on mortality in a...

Mixed methods evaluation of an international internet-based continuing medical education course for pediatric HIV providers in Pune, India

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2011-04-09

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Education for Health

Context: Studies of HIV care in Pune, a high-HIV-prevalence city in India, have shown that a significant proportion of practitioners were not adhering to national guidelines due to inadequate awareness and understanding. Objectives: This study examined the...

Twelve month follow-up of the SWEN randomized controlled trials: Differential impact of extended-dose nevirapine on mother-to-child transmission and infant death by maternal CD4 cell count

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2011-03-27

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AIDS Care

Objectives: We previously reported combined analysis of 6-week and 6-month endpoints of three randomized controlled trials [Six Week Extended Dose Nevirapine (SWEN) trials] that compared extended-dose nevirapine through 6 weeks of age to single-dose nevirapine to prevent HIV transmission via...

Predictors of retention among men attending STI clinics in HIV prevention programs and research: A case control study in Pune, India

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2011-03-11

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PLOS One

Background: Retention is critical in HIV prevention programs and clinical research. We studied retention in the three modeled scenarios of primary prevention programs, cohort studies and clinical trials to identify predictors of retention. Methodology/Principal Findings: Men attending Sexually...

Maternal tuberculosis: a risk factor for mother-to-child transmission of human immunodeficiency virus

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2011-02-01

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The Journal of Infectious Diseases

Background: Maternal human immunodeficiency virus (HIV) RNA load, CD4 cell count, breast-feeding, antiretroviral use, and malaria are well-established factors associated with mother-to-child transmission (MTCT) of HIV; the role of maternal tuberculosis (TB), however, has not been well...

Public private partnerships for emergency obstetric care: lessons from Maharashtra

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2011-01-15

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Indian Journal of Community Medicine

Abstract Background: The National Rural Health Mission of India advocates public private partnerships (PPPs) to meet its "service guarantee" of Emergency obstetric care (EmOC) provision. The Janani Suraksha Yojana (JSY) has a provision of Rs. 1500 for contracting in...

Stigmatizing attitudes and low levels of knowledge but high willingness to participate in HIV management: A community based survey of pharmacies in Pune, India

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2010-08-27

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BMC Public Health

Background: The World Health Organization (WHO) recommends that the role of pharmacists in low-income settings be expanded to address the increasing complexity of HIV antiretroviral (ARV) and co-infection drug regimens. However, in many such settings including in India, many pharmacists and...

Physician estimate of antiretroviral adherence: poor correlation with patient self-report and viral load

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2010-03-15

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AIDS Patient Care and STDs

Adherence to antiretroviral therapy (ART) is critical in maintaining viral suppression and minimizing resistance in HIV-infected patients. We compared physician estimates of their patients' ART adherence with participant's self-reported adherence to determine patient-provider agreement and identify...

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