India

With a population of more than one billion, India is the second largest country in the world, represents 16% of the global population, and the national average for life expectancy is only 65 years. India leads the world in the largest absolute burden of TB, ranks third for HIV (behind South Africa and Nigeria), and ranks second for diabetes. The country receives funding to support HIV/AIDS prevention, treatment and care programs under the US President's Emergency Plan for AIDS Relief (PEPFAR).

Our Indo-JHU Clinical Research Partnership is dedicated to reversing poor patient outcomes. With operations based in Pune, our extensive research portfolio is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya Mave, Dr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and, in addition to our memberships in consortia with many esteemed Indian research institutions, we have formal agreements with:

Byramjee Jeejeebhoy Government Medical College, and Sassoon General Hospital (BJGMC). Pune, India
DY Patil Medical College, Hospital and Research Center. Pune, India
National Institute for Research in Tuberculosis. Chennai, India
PD Hinduja Hospital and Medical Group. Mumbai, India
Medanta The Medicity. Gurgaon, India
KEM Hospital. Pune, India
Bharati Vidyapeeth Medical College. Pune, India

CCGHE WORK IN INDIA

Studies/Projects
Publications

Diagnosis of Active Tuberculosis in HIV-infected and Uninfected Young Children in India

Post Date:

2012-07-24

|

Countries:

|

Clinical Sites:

Tuberculosis (TB) is the most common cause of morbidity/mortality in HIV-infected individuals in India. India has the world's highest burden of HIV and TB, and since children acquire HIV/TB from their caregivers, active TB is highly prevalent (14-67.5%) among HIV-infected young children in...

A5288: MULTIOCTAVE, Management Using the Latest Technologies in Resource-limited Settings to Optimize Combination Therapy After Viral Failure

Post Date:

2012-07-16

|

Countries:

This study was terminated in March 2020. It was a mult-country clinical trial conducted in Brazil, Haiti, India, Kenya, Malawi, Peru, South Africa, Thailand, Uganda, and Zambia under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. ...

RePORT India

Post Date:

2012-06-30

|

Countries:

|

Clinical Sites:

Hinduja Hospital

RePORT India is a joint venture between the Indian and US governments. The Indo-US Vaccine Action Program, a collaboration between the Indian Department of Biotechnology (DBT), the Indian Council of Medical Research (ICMR), and the US NIH, is co-funding six teams of India- and US-based...

C-TRIUMPH Pilot Study: Burden and Risk Factors for Drug-resistant Tuberculosis in Pune, India

Post Date:

2012-05-29

|

Countries:

|

Clinical Sites:

This pilot study ended in April 2015. Drug resistant TB (MDR-TB and XDR-TB) is increasing worldwide. Although 20% of all global TB cases occur in India, current estimates of the burden of MDR-TB in India are limited. A well-characterized TB clinical cohort, household cohort and control cohort would...

Tuberculosis (TB) Diagnosis, Treatment, and Prevention Course

Post Date:

2012-01-01

|

Countries:

To strengthen tuberculosis (TB) clinical care and research in India and Pakistan, CCGHE collaborated with BJGMC, the National AIDS Research Institute (NARI) and Indus Hospital to develop and deploy the Tuberculosis (TB) Diagnosis, Treatment ,and Prevention course. Originally developed as a...

Impact Evaluation of Tobacco Cessation Intervention for Tuberculosis patients under Revised National Tuberculosis Control Programme in Rural and Urban areas at Vadodara, Gujarat, INDIA

Post Date:

2011-12-09

|

Countries:

TBA

Understanding Challenges and Perspectives of Parents about HIV Disclosures to their Children and Develop a Structured HIV Disclosure Model for Pediatric Age Group

Post Date:

2011-12-08

|

Countries:

|

Clinical Sites:

This study is terminated. In 2008 an estimated 70,000 children in India were living with HIV, with 21,000 new children are infected each year through mother to child transmission (Singh et al 2008). Increasing availability of antiretroviral treatment (ART) to HIV infected children in India means...

Sexually Transmitted Infections among Women in the Reproductive Age Group in Shevgaon, Ahmednagar District, Maharashtra, India

Post Date:

2011-05-15

|

Countries:

This study was conducted in 2011. Sexually transmitted infections (STIs) constitute a significant epidemiological burden all over the world especially in middle and low income countries. Women are more vulnerable to STIs due to several biological and socio-economic reasons. Although transmission of...

A5273: Multicenter Study of Options for Second-Line Effective Combination Therapy (SELECT)

Post Date:

2011-05-12

|

Countries:

|

Clinical Sites:

This study was terminated May 2, 2017; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. This was a multinational clinical trial conducted in Brazil, India, Kenya, Malawi, Peru, South Africa, Tanzania, Thailand...

Predictors of Perinatal HBV Transmission in an HIV/HBV Infected Cohort

Post Date:

2011-04-22

|

Countries:

This study ended in 2014. Hepatitis B virus (HBV) coinfection is common; affecting greater than 10% of HIV-infected individuals in resource-limited settings(1-3). Although the impact of HIV disease on HBV coinfection has been studied in non-pregnant adults, little is known...

A5282: A Randomized, Phase II Trial to Compare an HPV Test-and-Treat Strategy to a Cytology-Based Strategy for Prevention of CIN 2+ in HIV-Infected Women

Post Date:

2011-03-15

|

Countries:

Indo-JHU partnership work on this trial was officially terminated September 10, 2018; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. This multi-country trial is being conducted in Botswana, Haiti, India,...

A Prospective Study Evaluating the Role of Cryptococcal Antigen Screening among HIV-infected Adults with Low CD4 Counts

Post Date:

2011-01-01

|

Countries:

|

Clinical Sites:

This prospective observational study aimed to evaluate the burden of cryptococcal disease among approximately 200 HIV-infected adults with low CD4 cell counts in Pune, India to determine whether a Cryptococcal screening strategy should be the standard of care among patients with advanced HIV...

The Role of Vitamin D in the Development of Active Tuberculosis Disease in Young Children

Post Date:

2010-12-09

|

Countries:

|

Clinical Sites:

This study was terminated September 2014. Mycobacterium tuberculosis (MTB) results in significant morbidity and mortality worldwide, yet remains difficult to diagnose and manage, particularly in resource constrained settings. Deficiency in vitamin D, a recently recognized...

P1073: Study of Immune Reconstitution Inflammatory Syndrome (IRIS) for International Sites Initiating Highly Active Antiretroviral Therapy (HAART) in Infants and Children < 72 Months of Age

Post Date:

2010-11-15

|

Countries:

|

Clinical Sites:

This study was terminated April 23, 2015. This was a multi-national study conducted in India, South Africa, and Tanzania under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health...

Retrospective Characterization of Clinical and Demographic Data of Pediatric Tuberculosis Patients Treated at BJ Medical College in Pune, India

Post Date:

2010-06-10

|

Countries:

|

Clinical Sites:

This study ended June 14, 2013.

Hospitalized Pediatric Patients with Pandemic 2009 H1N1 Influenza in India (August-November 2009)

Post Date:

2010-04-10

|

Countries:

|

Clinical Sites:

This study ended in April 2013. This was a review and collection of data from the medical records of pediatric patients who were admitted to the BJMC/Sassoon General Hospitals with H1N1 influenza during August-November 2009.

P1077BF: Breastfeeding Version of the PROMISE Study (Promoting Maternal and Infant Survival Everywhere)

Post Date:

2010-02-02

|

Countries:

This trial was terminated November 6, 2019. This multi-country trial is being conducted in India, Malawi, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe, conducted under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded...

P1077FF: Formula Feeding Version of the PROMISE Study (Promoting Maternal and Infant Survival Everywhere)

Post Date:

2010-02-02

|

Countries:

This trial was terminated November 6, 2019. This multi-country trial is being conducted in India, Malawi, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe, under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S...

Assessment of Active Tuberculosis amongst Asymptomatic HIV-infected Patients in Kakinada, India

Post Date:

2009-07-23

|

Countries:

This study was conducted in 2008. Tuberculosis (TB) is a major public health threat in India and is the leading cause of morbidity and mortality amongst people living with HIV/AIDS worldwide.1 According to the WHO, India accounts for one-fifth of the global TB incident cases...

A5225: Phase I/II Dose-Finding Study of High-Dose Fluconazole Treatment in AIDS-Associated Cryptococcal Meningitis

Post Date:

2009-04-22

|

Countries:

|

Clinical Sites:

This trial was terminated in March 2015; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. This multi-country study was conducted in India, Kenyam Peru, South Africa, Thailand, Uganda, United States, and...

Pages

Maternal health outcomes among HIV-infected breastfeeding women with high CD4 counts: results of a treatment strategy trial

Post Date:

2019-03-20

|

Countries:

Publication:

HIV Clinical Trials

BACKGROUND: IMPAACT PROMISE 1077BF/FF was a randomized study of antiretroviral therapy (ART) strategies for pregnant and postpartum women with high CD4+ T-cell counts. We describe postpartum outcomes for women in the study who were randomized to continue or discontinue ART after...

Elevated highly sensitive C-reactive protein and d-dimer levels are associated with food insecurity among people living with HIV in Pune, India

Post Date:

2019-03-04

|

Countries:

|

Clinical Sites:

Publication:

Public Health Nutrition

Abstract OBJECTIVE: To assess the prevalence and determinants of food insecurity among people living with HIV (PLWH) in Pune, India and its association with biomarkers known to confer increased risks of morbidity and mortality in this population. DESIGN:...

Female global health leadership: Data-driven approaches to close the gender gap

Post Date:

2019-02-09

|

Countries:

|

Clinical Sites:

Publication:

The Lancet

Lancet article investigates gender-based challenges of female health trainees and professionals and identifies interventions

Few eligible for the newly recommended short course MDR-TB regimen at a large Mumbai private clinic

Post Date:

2019-01-28

|

Countries:

|

Clinical Sites:

Hinduja Hospital

Publication:

BMC Infectious Diseases

BACKGROUND: India has the world's highest tuberculosis burden, and Mumbai is particularly affected by multidrug resistant tuberculosis (MDR-TB). WHO recommends short, intensive treatment ("Short Course") for previously untreated pulmonary MDR-TB patients but does not require universal...

HIV testing uptake among the household contacts of multidrug-resistant tuberculosis index cases in eight countries

Post Date:

2019-01-07

|

Countries:

|

Clinical Sites:

Publication:

International Journal of Tuberculosis and Lung Disease

International Journal of Tuberculosis and Lung Disease : The Indo-JHU Clinical Research Parentership participated in this multinational study to determine if it's feasible to provide HIV testing for household contacts of MDR-TB cases.

Is there a connection between gestational diabetes, human immunodeficiency virus infection, and tuberculosis?

Post Date:

2019-01-01

|

Countries:

|

Clinical Sites:

Publication:

International Journal of Tuberculosis and Lung Disease

IJTLD article reviews the epidemiology and immunology of gestational diabetes and finds there's a lot we don't know about interactions between diabetes, pregnancy, and tuberculosis in both HIV+/- women

Multiplex-PCR to detect pAmpC β-lactamases among Enterobacteriaceae at a tertiary care laboratory in Mumbai, India

Post Date:

2018-12-13

|

Countries:

|

Clinical Sites:

Hinduja Hospital

Publication:

Microbiology

Drug-resistance due to AmpC β-lactamases represents a growing problem worldwide. In this study, a previously collected sample of 108 cefoxitin-resistant clinical isolates was assessed for AmpC β-lactamase production through routine phenotypic testing and double-disc cefoxitin/cloxcallin (DD-CC),...

The mortality burden of multidrug-resistant pathogens in India: a retrospective observational study

Post Date:

2018-11-08

|

Countries:

Publication:

Clinical Infectious Diseases

We conducted a retrospective, ten hospital study of the relationship between multidrug-resistant pathogens and mortality in India. This is one of the largest studies undertaken in an LMIC to measure the burden of antibiotic resistance.

Drug-resistant Enterobacteriaceae colonization is associated with healthcare utilization and antimicrobial use among inpatients in Pune, India

Post Date:

2018-10-04

|

Countries:

|

Clinical Sites:

Publication:

BMC Infectious Diseases

BACKGROUND: Healthcare exposure may increase drug-resistant Enterobacteriaceae colonization risk. Nascent antimicrobial stewardship efforts in low- and middle-income countries require setting-specific data. We aimed to evaluate risk factors for inpatient drug resistant...

Barriers to screening and isoniazid preventive therapy for child contacts of tuberculosis patients

Post Date:

2018-10-01

|

Countries:

|

Clinical Sites:

Publication:

International Journal of Tuberculosis and Lung Disease

Universal, timely TB screening and IPT for exposed children are urgently needed to reduce pediatric TB in India

Inflammation and micronutrient biomarkers predict clinical HIV treatment failure and incident active TB in HIV-infected adults: a case-control study

Post Date:

2018-09-24

|

Countries:

|

Clinical Sites:

Publication:

BMC Medicine

Factors identified through exploratory factor analysis were associated with adverse outcomes in HIV-infected individuals.

Ovarian mass - tuberculosis or malignancy? Need for early intensified evaluation

Post Date:

2018-09-14

|

Countries:

|

Clinical Sites:

Publication:

EXCLI Journal

Letter to the Editor Dear Editor, We read with interest the case report by Chien et al. on Peritoneal Tuberculosis (TB) mimicking ovarian cancer (Chien et al., 2016[1]). We want to congratulate the authors on this case report. We encountered a similar case in our clinical setting in western India...

The association of household fine particulate matter and kerosene with tuberculosis in women and children in Pune, India

Post Date:

2018-09-07

|

Countries:

|

Clinical Sites:

Publication:

Occupational and Environmental Medicine

Use of kerosene cooking fuel is positively associated with TB in women and children in our analysis using reported sources of exposure.

Challenges and opportunities for outreach workers in the Prevention of Mother to Child Transmission of HIV (PMTCT) program in India

Post Date:

2018-09-04

|

Countries:

Publication:

PLoS One

PLoS One: Prevention of Mother-to-Child Transmission of HIV program in India is one of the largest in the world, and it relies on outreach workers. Our study looked at challenges and opportunities for outreach workers.

The effect of diabetes mellitus on the pharmacokinetics and pharmacodynamics of tuberculosis treatment

Post Date:

2018-08-20

|

Countries:

|

Clinical Sites:

Publication:

Antimicrobial Agents and Chemotherapy

DM and higher HbA1c increased the risk of not achieving therapeutic targets for pyrazinamide, but higher pyrazinamide concentrations were asociated with worse microbiologic and clinical outcomes

Tuberculin skin test and QuantiFERON-Gold In Tube assay for diagnosis of latent TB infection among household contacts of pulmonary TB patients in high TB burden setting

Post Date:

2018-08-01

|

Countries:

Publication:

PLoS One

World Health Organization (WHO) recommends systematic screening of high-risk populations, including household contacts (HHCs) of adult pulmonary tuberculosis (TB) patients, as a key strategy for elimination of TB. QuantiFERON-TB Gold In-Tube (QFT-GIT) assay and tuberculin skin test (TST) are two commonly used tools for the detection of latent tuberculosis infection (LTBI) but may yield differential results, affecting eligibility for TB preventive therapy.

Trends in HbA1c levels and implications for diabetes screening in tuberculosis cases undergoing treatment in India

Post Date:

2018-07-01

|

Countries:

|

Clinical Sites:

Publication:

International Journal of Tuberculosis and Lung Disease

SETTING: The optimal timing of screening for diabetes mellitus (DM) among tuberculosis (TB) cases is unclear due to the possibility of stress hyperglycemia. DESIGN: We evaluated adult (18 years) pulmonary TB cases at treatment initiation as well as at 3 months,...

Loss to follow‐up and mortality among HIV‐infected adolescents receiving antiretroviral therapy in Pune, India

Post Date:

2018-06-25

|

Countries:

|

Clinical Sites:

Publication:

HIV Medicine

Over 6 years, one-third of HIV+ adolescents in this study discontinued medical treatment, indicating a critical need for retention counselling and closer clinical monitoring.

Diabetes and prediabetes among household contacts of tuberculosis patients in India: Is it time to screen them all?

Post Date:

2018-06-01

|

Countries:

|

Clinical Sites:

Publication:

International Union Against Tuberculosis and Lung Disease

SETTING: Pre-diabetes mellitus (pre-DM) and DM increase the risk of developing tuberculosis (TB). Screening contacts of TB patients for pre-DM/DM and linking them to care may mitigate the risk of developing TB and improve DM management. OBJECTIVE: To measure the prevalence of pre-DM/DM and...

Effect of baseline micronutrient and inflammation status on CD4 recovery post-cART initiation in the multinational PEARLS trial

Post Date:

2018-05-29

|

Countries:

Publication:

Clinical Nutrition

Nutritional deficiency and inflammation may impact CD4+ T cell recovery during combination antiretroviral therapy (cART), particularly in resource-limited settings where malnutrition is prevalent. The aim of this study was to investigate the relationship of micronutrient and inflammation biomarkers to CD4 recovery after cART initiation.

Pages