Research News

November 22, 2022

To determine the mechanisms that mediate resistance to Mycobacterium tuberculosis (M. tuberculosis) infection in household contacts (HHCs) of patients with tuberculosis (TB), we followed 452 latent TB infection-negative (LTBI-) HHCs for 2 years.

Clinical Research

Leadership
Our Indo-JHU Clinical Research Partnership is located in Pune and is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya Mave, Dr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and in addition to our memberships in consortia with many esteemed Indian research institutions, we have formal agreements with:
 
 

RADx Tech COVID-19 Test Us Study

Post Date: 
2020-07-27
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Scalable, inexpensive novel technologies that enable detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus are desperately needed. However, understanding the accuracy and usability of novel technologies for SARS-CoV-2 is critical. Each novel test needs to be evaluated...

Tuberculosis (TB) Aftermath

Post Date: 
2020-06-05
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Drs. Vidya Mave and Jonathan Golub are co-PIs and Dr. Barthwal from DY Patil Medical College is local site PI for this study. TB Aftermath seeks to provide evidence for an effective and scalable strategy targeting HHs of treated TB cases, a high priority of the NTEP. Purpose To compare the...

Mental Health Outcomes among Health Care Professionals Involved in the Treatment and Care of COVID 19 Patients in India

Post Date: 
2020-06-01
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Drs. Nikhil Gupta and Nishi Suryavanshi are leading this survey project. This study is investigating the immediate impact of the COVID-19 pandemic on mental health outcomes and overall quality of life and what are the factors associated with it among Indian Health care workers. Among health care...

Prevalence of Risk Factors for Lung Cancer and Facilitators and Barriers for Tobacco Cessation among People Living with HIV

Post Date: 
2020-04-01
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India has the world’s third largest HIV epidemic, with 2.1 million people currently living with HIV and an additional 90,000 new infections each year.[29] At the same time, expansion of the HIV response under India’s premier governmental agency - the National AIDS Control Organization (NACO), has...

The Sentinel Research Network of IeDEA: A Prospective Cohort among People Living with HIV

Post Date: 
2020-03-12
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This study is nested within the TREAT Asia HIV Observational Database initiative. The global scale up of antiretroviral therapy (ART) has significantly improved the immune recovery and life expectancy of people living with HIV (PLHIV). However, PLHIV on long-term ART now face health challenges...

Hybrid Trial for Alcohol Reduction among People with TB and HIV in India

Post Date: 
2020-02-12
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Dr. Geetanjali Chander is PI and Dr. Kakrani is local site PI at DY Patil Medical College for this study. The highest incidence of tuberculosis disease (TB) in the world is in India, accounting for 27% of all new cases globally, with approximately 86,000 among persons with HIV (PWH). Unhealthy...

Increasing Market and Public Health Outcomes Through Scaling Up Affordable Access Models of Short Course Preventive Therapy for TB (IMPAACT4TB)

Post Date: 
2019-12-17
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Primary Objective: This study is being conducted in Brazil, Cambodia, China, Ethiopia, Ghana, Haiti, India, Indonesia, Kenya, Malawi, Mozambique, South Africa, Tanzania, and Zimbabwe. The overall goal is to reduce TB incidence among (1) people living with HIV who are on antiretroviral therapy, and...

Markers of Lung Impairment in HIV-TB Coinfected Indian Adults

Post Date: 
2019-12-11
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Objectives/Aims We will compare the degree of lung impairment between HIV-TB co-infected adults (HIV-TB group) and TB cases without HIV co-infection (TB group) who successfully complete TB therapy. We hypothesize that the HIV-TB group will have a greater degree of lung...

Inflammasome Genetics and Tuberculosis Treatment Outcomes

Post Date: 
2019-11-07
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Dr. Amita Gupta is a Co-PI on this study. STUDY DESIGN We will conduct a retrospective case-cohort study nested within the CTRIUMPH and EDOTS cohorts to address our study objectives. This will enable us to measure the association of polymorphisms with multiple clinical outcomes simultaneously and...

Evaluation of a Urinary Biomarker Assay for Diagnosis and Test of Cure for Tuberculosis

Post Date: 
2019-09-09
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Dr. Jeff Tornheim is PI of this study. METHODS This study will make use of biorepository samples from the Cohort for TB Research by the Indo-US Medical Partnership (CTRIUMPh). CTRIUMPh, funded by the US NIH and Indian Department of Biotechnology, is an academic collaboration between Johns Hopkins...

A5300B/I2003B: Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx)

Post Date: 
2019-08-19
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Dr. Amita Gupta is Protocol Co-chair for this multinational clinical trial. BACKGROUND The World Health Organization (WHO) estimates that there were 480,000 incident cases of MDR-TB globally in 2015. MDR-TB has been shown to be almost twice as common in TB...

A5300B/I2003B: Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx)

Post Date: 
2019-08-19
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Dr. Amita Gupta is Protocol Co-chair for this multinational clinical trial. BACKGROUND The World Health Organization (WHO) estimates that there were 480,000 incident cases of MDR-TB globally in 2015. MDR-TB has been shown to be almost twice as common in TB...

Visual Field Loss in HIV-Positive Patients of Non-Infectious HIV Retinopathy

Post Date: 
2019-06-02
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New study will assess HIV+ patients and determine the prevalence of visual field loss due to noninfectious HIV retinopathy

Immune Correlates of LTBI in HIV-exposed Infants

Post Date: 
2019-04-29
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About 2 billion people worldwide harbor asymptomatic latent TB infection (LTBI), activation of which results in progression to TB disease. In areas of high tuberculosis (TB) prevalence, infants and young children have a 3-fold higher risk of progression and death from TB at age < 5 years...

P2010: Phase III Study of the Virologic Efficacy and Safety of Dolutegravir-Containing versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and their Infants “VESTED”

Post Date: 
2019-02-06
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This study was terminated September 2, 2021 Full Title: P2010: Phase III Study of the Virologic Efficacy and Safety of Dolutegravir-Containing versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and their Infants “...

Prevalence of Tuberculosis in Severely Malnourished Indian Children

Post Date: 
2018-12-18
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This study is funded and conducted under the U.S. National Institutes of Health, Fogarty International Center. PIs are Robert Bollinger, MD, MPH; Dr. Muralidhar Tambe, BJGMC Severely malnourished children are vulnerable population for communicable and non-communicable...

Characterization of Genomics and Metabolomics among Individuals Highly-Exposed, but Resistant to MTB Infection

Post Date: 
2018-12-13
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New study launched in India & South Africa to identify functional relationships between genomics & metabolomics, & to characterize fundamental biological systems underlying resistance to Mtb infection.

Host RNA Expression for Diagnosis and Monitoring of Pediatric TB in Africa and India

Post Date: 
2018-12-13
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We are leveraging the RePORT platform by including a cohort of Indian children together with South African children in a large validation study to study on changes in gene expression profiles during treatment for TB

Characterization of TB-specific T Cell Responses in Highly-exposed, but Uninfected Health Care Workers in India

Post Date: 
2018-10-25
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This study is funded and conducted under the U.S. National Institutes of Health, Fogarty International Center. PIs are Robert Bollinger, MD, MPH; Jyothi Rengarajan, MD, Emory University. Primary Research Question Do health care workers who remain TST...

Vaginal Microbiota in HIV Infected and Uninfected Pregnant Women (Stand Alone)

Post Date: 
2018-10-16
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Amita Gupta, MD, MHS, and Shilpa Naik, MD, are PIs for this study; Rupak Shivakoti, PhD, MSPH, is Co-Investigator The makeup of vaginal microbiota is dynamic and may play a role in the birth outcomes of pregnant women. While HIV and pregnancy both uniquely impact vaginal microbiota, the impact of...

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Drug use stigma, antiretroviral therapy use, and HIV viral suppression in a community-based sample of people with HIV who inject drugs

Post Date: 
2022-10-06
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AIDS
Drug use stigma may be a barrier to HIV viral suppression among people with HIV who inject drugs, thereby hindering efforts to achieve HIV control.

Whole Genome Sequencing Assessing Impact of Diabetes Mellitus on Tuberculosis Mutations and Type of Recurrence in India

Post Date: 
2022-10-06
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Clinical Infectious Diseases
Dr. Vidya Mave and colleagues concluded considerable intrahost mycobacterium tuberculosis mutation rates were present at recurrence among patients with diabetes mellitus.

Clinical and Immunological Markers of Pulmonary Impairment Among People With HIV in India

Post Date: 
2022-10-06
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Open Form Infectious Diseases
Dr. Akshay Gupte and team found females were 7 times more likely to have restrictive spirometry pattern and 22 times more likely to have preserved ratio impaired spirometry, compared with men.

Changes in HIV care continuum indicators among community-based samples of HIV-infected people who inject drugs and men who have sex with men across 21 cities in India

Post Date: 
2022-10-06
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AIDS Care
The findings by Drs. Shruti Mehta, Gregory Lucas and colleagues show population-specific interventions and routine surveillance are need to facilitate HIV elimination.

Geographical Differences in the Self-Reported Functional Impairment of People with HIV and Associations with Cardiometabolic Risk

Post Date: 
2022-09-30
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Clinical Infectious Disease
Background We sought to explore multinational differences in functional status by global burden of disease (GBD) regions in the REPRIEVE cohort. Methods REPRIEVE is a prospective, double-blind, randomized, placebo-controlled, multicenter, phase III primary cardiovascular prevention study of...

Population Pharmacokinetic Modeling and Simulation of Rifapentine Allow Concomitant Antiretroviral Therapy with Efavirenz and Non-Weight Based Dosing

Post Date: 
2022-09-20
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Antimicrobial Agents and Chemotherapy
ABSTRACT The Brief Rifapentine–Isoniazid Efficacy for TB Prevention/A5279 trial demonstrated a 1-month daily regimen of rifapentine and isoniazid was noninferior to 9 months of isoniazid alone for preventing TB in persons living with HIV (PLWH). Our objective was to evaluate rifapentine...

Accuracy of Xpert MTB/RIF Ultra for the diagnosis of tuberculosis in adult patients: a retrospective cohort study

Post Date: 
2022-09-01
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International Journal of Infectious Diseases
Abstract Objectives: The value of the "trace" result in Xpert Ultra for diagnosing active tuberculosis (TB) remains unclear. Our study evaluated the diagnostic accuracy of Xpert MTB/RIF Ultra (Xpert Ultra) (Cepheid, Sunnyvale, USA) over Xpert MTB/RIF (Xpert) (Cepheid, Sunnyvale, USA) and...

Accurate Detection of Esophageal Squamous Cell Carcinoma (ESCC) Using Machine Learning with Methylated DNA Biomarkers

Post Date: 
2022-08-15
Publication: 
Science Direct Gastroenterology
Esophageal cancer, with 544,076 deaths in 2020,1 includes esophageal adenocarcinoma and esophageal squamous cell carcinoma (ESCC). ESCC comprises 90% of esophageal cancers globally. The 5-year survival rate remains poor (15%–25% worldwide) because patients usually present with late disease.2...

Concomitant pulmonary disease is common among patients with extrapulmonary TB

Post Date: 
2022-08-12
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International Journal of Tuberculosis and Lung Disease
Dr. Shivakumar and his group discovered that a high proportion of patients classified as EPTB in India have concomitant PTB. Their results support the need for improved symptom and CXR screening, and recommends routine sputum TB microbiology screening of all Indian patients with EPTB.

The association of gestational diabetes with HIV infection and tuberculosis in Indian women

Post Date: 
2022-08-01
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The American Journal of Tropical Medicine and Hygiene
Infection of HIV is associated with an increased diabetes risk, which also increases tuberculosis risk. It is unknown if similar associations exist with gestational diabetes (GDM). We screened pregnant women living with and without HIV for GDM using oral glucose tolerance testing. In a subgroup of...

Pregnancy in Women with HIV in a Tuberculosis Preventive Therapy Trial

Post Date: 
2022-08-01
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JAIDS
Background: Tuberculosis preventive therapy (TPT) is recommended for people with HIV infection, including during pregnancy. The effect of TPT exposure at conception and during pregnancy is poorly documented. Methods: We report pregnancy outcomes among South African women...

Development of shortened HIV-related stigma scales for young people living with HIV and young people affected by HIV in India

Post Date: 
2022-07-31
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BMC Health and Quality of Life Outcomes
Background: HIV-related stigma is associated with poor quality of life and poor healthcare-seeking behaviours in young people living with HIV (YPLHIV) and young people affected by HIV (YPAHIV). India has an estimated 120,000 YPLHIV and 4 million YPAHIV, but efforts to measure HIV-related stigma in...

High-Intensity Versus Standard Thromboprophylaxis Among Adults Hospitalized with COVID-19: A Retrospective Cohort Study

Post Date: 
2022-07-22
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Research and Practice in Thrombosis and Haemostasis
Background and Objectives Current clinical guidelines recommend thromboprophylaxis for adults hospitalized with coronavirus disease 2019 (COVID‐19), yet it is unknown whether higher doses of thromboprophylaxis offer benefits beyond standard doses. Methods We studied electronic health records from...

Comparative immune responses to M. tuberculosis in individuals with latent infection or sterile protection against infection

Post Date: 
2022-07-13
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bioRxiv
Summary To identify immunologic targets for tuberculosis vaccines more efficacious than BCG, we investigated the immune responses that differentiate individuals with sterile protection against M. tuberculosis (Mtb) infection (TB-resisters) from those who develop latent tuberculosis infection (LTBI-...

Smokeless tobacco use and oral potentially malignant disorders among people living with HIV (PLHIV) in Pune, India: Implications for oral cancer screening in PLHIV

Post Date: 
2022-07-13
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PLOS ONE
Introduction In India, smokeless tobacco (SLT) is a predominant form of tobacco used among people living with HIV (PLHIV). Despite SLT being a risk factor for oral potentially malignant disorders (OPMDs), no prior studies have quantified the association of OPMDs with SLT use among PLHIV. This...

Impact of SARS-CoV-2 variants on inpatient clinical outcome

Post Date: 
2022-07-11
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Clinical Infectious Diseases
Background Prior observation has shown differences in COVID-19 hospitalization risk between SARS-CoV-2 variants, but limited information describes hospitalization outcomes. Methods Inpatients with COVID-19 at 5 hospitals in the eastern United States were included if they had hypoxia, tachypnea,...

Isoniazid adherence improves survival and incident tuberculosis at 96 weeks among adults initiating antiretroviral therapy with advanced HIV in multiple high burden settings

Post Date: 
2022-07-03
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Open Forum Infectious Diseases
Background People with human immunodeficiency virus (HIV) and advanced immunosuppression initiating antiretroviral therapy (ART) remain vulnerable to tuberculosis (TB) and early mortality. To improve early survival, isoniazid preventive therapy (IPT) or empiric TB treatment have been evaluated;...

Inflammatory profile associated with insulin resistance in non-overweight versus overweight people living with HIV in Pune, Western India

Post Date: 
2022-07-01
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Diabetes & Metabolic Syndrome: Clinical Research & Reviews
Background: People living with HIV have greater diabetes (T2DM) than the general population despite lower prevalence of overweight/obesity. Both insulin resistance (IR), a T2DM precursor, and HIV are independently associated with chronic inflammation. Inflammation may be a pathophysiological link...

Prevalence of neurotoxicity symptoms among postpartum women on Isoniazid Preventive Therapy and Efavirenz-based treatment for HIV—An exploratory objective of the IMPAACT P1078 randomized trial

Post Date: 
2022-06-21
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Publication: 
BMC Pregnancy and Childbirth
Background This exploratory analysis investigates the prevalence and risk factors of neurocognitive toxicity in postpartum women on HIV treatment in response to a concern of an Isoniazid Preventive Therapy (IPT)/Efavirenz interaction. Trial Design Pregnant women on HIV treatment from countries with...

Diagnostic biomarkers for active tuberculosis: Progress and challenges

Post Date: 
2022-06-20
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EMBO Molecular Medicine
Tuberculosis (TB) is a leading cause of morbidity and mortality from a single infectious agent, despite being preventable and curable. Early and accurate diagnosis of active TB is critical to both enhance patient care, improve patient outcomes, and break Mycobacterium tuberculosis (Mtb)...

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Research Story Tip: Grants, Management Roles Keep Johns Hopkins A Leader In Hiv/Aids Clinical Trial Research

Post Date: 
2020-12-08
Research Story Tip
Researchers at Johns Hopkins Medicine learned that they now have an enhanced opportunity to help move the world toward a day when that observance is rendered obsolete.

Research Update: TB Trials Conducted by JHU-India Team Will Shorten Drug-Susceptible TB Treatment for Children and Adults

Post Date: 
2020-12-07
Research Updated
Reporting from the virtual 51st Union Conference on Lung Health, the World Health Organization (WHO) and the U.S. Centers for Disease Control and Prevention (CDC) announced promising findings from 2 TB trials

Leslie Marshall interviews Dr. Bob Bollinger on Latest COVID-19 News, Including Vaccines

Post Date: 
2020-10-07
Source: 
The Leslie Marshall Show
Dr. Robert Bollinger
CCGHE's Bob Bollinger talks with Leslie Marshall about the latest COVID-19 news, including vaccines.

Study Shows Extent, Danger of TB Exposure: Part I

Post Date: 
2020-08-24
Source: 
Medical Daily
Medical Daily: Amita Gupta and Mandar Paradkar are quoted in this report about TB preventive therapy for household contacts of confirmed cases in India

Research Story Tip: International Johns Hopkins Study Says Broad Measures Needed to Prevent TB Spread in India

Post Date: 
2020-08-06
Dr. Mandar Paradkar
Johns Hopkins News Release: News release highlights study findings published in PLOS One by Dr. Mandar Paradkar and colleagues.

Broad measures needed to check spread of TB in India: Study

Post Date: 
2020-08-05
Source: 
daijiworld.com
daijiworld.com (India): Dr. Mandar Paradkar is quoted about his recent study on TB preventive therapy for household contact of TB cases.

Study Shows Mobile Health, Video Technology, Influence Behavior of Affected Populations

Post Date: 
2020-07-09
Dr. Nishi Suryavanshi
Johns Hopkins News Release: Dr. Suryavanshi discusses her study on mobile health and technology training for improving care among HIV+ pregnant and post-partum women and their babies

NIH Awards Johns Hopkins Baltimore-Washington-India Trials Group $460,679 in Supplemental COVID-19 Funding

Post Date: 
2020-06-30
The supplement is leveraging existing HIV research infrastructure and personnel for DAIDS-sponsored COVID research

ACTG Site Spotlight: BJGMC-JHU Clinical Research Site, Pune, India

Post Date: 
2020-05-05
Source: 
ACTG Network Newsletter
ACTG Logo
The BJGMC-JHU Clinical Research site in Pune, India, is highlighted in this article.

Pandemic Planning in Pune: Distributing Study Medication during COVID-19

Post Date: 
2020-04-23
Dr. Sandesh Patil
Dr. Sandesh Patil reports how the team in India ensured study participants received medication during the COVID-19 pandemic.

Want to end state lockdowns? Send in the coronavirus detectives.

Post Date: 
2020-04-21
Source: 
The Christian Science Monitor
Contact Tracing
CSM: Bob Bollinger discusses limitations in US capacity for tracing contacts of confirmed COVID-19 cases.

US needs more testing to ‘transfer the economy ahead,’ says Johns Hopkins infectious disease expert

Post Date: 
2020-04-09
Source: 
Gruntstuff
Dr. Robert Bollinger, CCGHE Director, was interviewed for this report on the COVID-19 pandemic. Particularly, the U.S. needs more speedy testing and a greater system of contact tracing to decide who has been contaminated by COVID-19 and who has not, Bollinger mentioned on “Energy...

‘Every part of the country’ still at risk — ex-FDA chief urges US to stay united in coronavirus fight

Post Date: 
2020-04-09
Source: 
CNBC
Additional testing and contact tracing efforts are critical in obtaining the information needed to “move the economy forward,” Dr. Robert Bollinger of Johns Hopkins University told CNBC earlier this week. He pointed to contact tracing programs in Massachusetts and Maryland as examples that need to...

We need to expand access to rapid coronavirus testing and contact tracing: Johns Hopkins’ Dr. Bollinger

Post Date: 
2020-04-08
Source: 
CNBC
Bollinger-CNBC
Dr. Bob Bollinger appeared on CNBC's ‘Power Lunch’ to discuss coronavirus response.

New York has 12 TIMES more deaths than California because the state was slow to react to the pandemic, late on lockdown rules and advised residents to 'go on with' their lives, experts say

Post Date: 
2020-04-08
Source: 
Daily Mail
Dr. Robert Bollinger, CCGHE Director, was interviewed for this report on the COVID-19 pandemic. New York has more than 12 times the number of coronavirus deaths than California because the state was slow to react to the pandemic, late on lockdown rules and had advised residents to 'go on with'...

EMA Panel Backs Pretomanid for Drug-Resistant TB

Post Date: 
2020-03-31
Source: 
Medscape
Amita Gupta is mentioned in this article.

Rifapentine demonstrates efficacy for pregnant women, including those with HIV

Post Date: 
2020-03-14
Source: 
Infectious Disease News via Healio
Dr. Jyoti Mathad
Infectious Disease News via Healio: Jyoti Mathad discusses findings from the IMPAACT 2001 clinical trial.

CCGHE at CROI 2020

Post Date: 
2020-03-04
CROI 2020
CCGHE is part of 17 presentations at this year's Conference of Retroviruses and Opportunistic Infections! Check out where we will be!

DBT-NIH support 9th annual meeting of RePORT India

Post Date: 
2020-02-17
Source: 
BioSpectrum
Representatives of RePORT India and P. D. Hinduja Hospital
Consortium is chaired by Dr. Sonali Sarkar on the Indian side and Dr. Amita Gupta U.S. side, with oversight provided by DBT and NIH.

CCGHE at the 2019 Union TB Conference

Post Date: 
2019-10-21
2019 Union World Conference on Lung Health
CCGHE researchers and faculty will be in Hyderbad for the Union Conference--check out our agenda!

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