Mandatory tuberculosis case notification in high tuberculosis-incidence countries: policy and practice

Post Date: 
2016-10-20
Publication: 
European Respiratory Journal
Mandatory tuberculosis (TB) notification is an important policy under the End TB Strategy, but little is known about its enforcement especially in high TB incidence countries. We undertook a literature search for selected high-incidence countries, followed by a questionnaire-based survey...

Next-generation sequencing in neuropathologic diagnosis of infections of the nervous system

Post Date: 
2016-06-13
Publication: 
Neurology, Neuroimmunology and Neuroinflammation
OBJECTIVE: To determine the feasibility of next-generation sequencing (NGS) microbiome approaches in the diagnosis of infectious disorders in brain or spinal cord biopsies in patients with suspected CNS infections. METHODS: In a...

Lyme carditis

Post Date: 
2015-06-15
Publication: 
Infectious Disease Clinics of North America
Lyme disease is a common disease that uncommonly affects the heart. Because of the rarity of this diagnosis and the frequent absence of other concurrent clinical manifestations of early Lyme disease, consideration of Lyme carditis demands a high level of suspicion when patients in endemic...

Dengue and chikungunya co-infection associated with more severe clinical disease than mono-infection

Post Date: 
2015-04-15
   |   
Countries: 
India
Publication: 
International Journal of Healthcare and Biomedical Research
Background: Dengue and chikungunya infections appear to be increasing in India. While Aedies aegypti is the transmitting vector for both viruses and co-infection occurs in the same communities, studies on the clinical significance of co-infection are limited. Materials and Methods: We conducted a...

Blood stream infections

Post Date: 
2014-07-01
Publication: 
BioMed Research International
Blood stream infection (BSI) is one of the most devastating preventable complications in Critical Care Units. It has far-reaching consequences resulting in prolonged length of hospital-stay, high costs to the individual and exchequer, and, in many instances, loss of life. Although exact rates...

Biomarkers for sepsis: a review with special attention to India

Post Date: 
2014-03-19
   |   
Countries: 
India
Publication: 
BioMed Research International
Sepsis is a serious infection and still a common cause of morbidity and mortality in resource-limited settings such as India. Even when microbiologic diagnostics are available, bacteremia is only identified in a proportion of patients who present with sepsis and bloodstream infections...

Maternal pneumococcal capsular IgG antibodies and transplacental transfer are lower in South Asian HIV-infected mother-infant pairs

Post Date: 
2014-03-14
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
Vaccine
Background: Our understanding of the mother-to-child transfer of serotype-specific pneumococcal antibodies is limited in non-immunized, HIV-positive women. Methods: We compared geometric mean antibody concentrations (GMCs), geometric mean transplacental...

Improving diagnostic capability for HPV disease internationally within the NIH-NIAID-Division of AIDS Clinical Trial Networks

Post Date: 
2013-12-15
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
American Journal of Clinical Pathology
OBJECTIVES: To evaluate an external quality assurance (EQA) program for the laboratory diagnosis of human papillomavirus (HPV) disease that was established to improve international research capability within the Division of AIDS at the National Institute of Allergy and Infectious Disease-supported...

India’s new policy to protect research participants

Post Date: 
2013-07-31
   |   
Countries: 
India
Publication: 
The BMJ
Editorial Introduction: India, the country with the largest disease burden in the world,1 is now a major international hub for clinical research. However, a recent policy that was meant to mitigate important ethical concerns may have profound and unintended consequences for public health and...

Predictors of mortality in hospitalized children with pandemic H1N1 influenza 2009 in Pune, India

Post Date: 
2012-04-15
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
Indian Journal of Pediatrics
Objective: To analyse the factors associated with increased mortality among Indian Children with H1N1. Methods: Data were abstracted from available hospital records of children less than 12 y of age, who were admitted to Sassoon General Hospital in Pune, India, with...

High rates of all-cause and gastroenteritis-related hospitalization morbidity and mortality among HIV-exposed Indian infants

Post Date: 
2011-07-15
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
BMC Infectious Diseases
Background: HIV-infected and HIV-exposed, uninfected infants experience a high burden of infectious morbidity and mortality. Hospitalization is an important metric for morbidity and is associated with high mortality, yet, little is known about rates and causes of hospitalization among these...

Incidence of common opportunistic infections in HIV-infected individuals in Pune, India: analysis by stages of immunosuppression represented by CD4 counts

Post Date: 
2008-07-02
Publication: 
International Journal of Infectious Diseases
Background: Opportunistic infections (OIs) influence the morbidity and mortality due to HIV infections. Data from India on the incidence of OIs among HIV-infected individuals by stages of immunodeficiency are scarce. Methods: Between September 2002 and...

Hematogenous osteomyelitis mimicking osteosarcoma due to Community Associated Methicillin-Resistant Staphylococcus aureus

Post Date: 
2007-06-15
Publication: 
Infection
Community Associated Methicillin - Resistant Staphylococcus aureus (CA-MRSA) is an emerging pathogen with increasing clinical significance. Initially recognized as a cause of skin and soft tissue infections, it has soon been shown to cause life threatening illnesses. We describe two cases of...

The traveling farm wife

Post Date: 
2007-01-15
Publication: 
American Journal of Medicine
In late summer, a 77-year-old woman was hospitalized after 9 days of chills, low-grade fever, fatigue, and generalized weakness. She did not have abdominal pain, coughing, diarrhea, dyspnea, jaundice, nausea, rashes, sore throat, vomiting, or weight loss. Her medical history was significant...

Evaluation of serologic screening for identification of chronic Salmonella typhi carriers in Vietnam

Post Date: 
2006-07-10
Publication: 
International Journal of Infectious Diseases
Objectives: To determine the utility of screening anti-Vi antibodies to detect chronic Salmonella Typhi carriers in an endemic community. Methods: We conducted a community-based serologic survey for anti-Vi antibodies to identify chronic Salmonella Typhi...

Screening for HIV dementia in an HIV, clade C-infected population in India

Post Date: 
2006-02-12
   |   
Countries: 
India
Publication: 
Journal of Neurovirology
Although human immunodeficiency virus (HIV) clade C virus infects the largest populations worldwide, to date there are no prospective studies reported thus far to determine the incidence or prevalence of HIV dementia in this population. HIV clade C virus is a CCR5-tropic virus and thus...

Rate of hospitalization and inpatient care costs for HIV-1 infected in Pune, India

Post Date: 
2006-02-01
   |   
Countries: 
India
Publication: 
National Medical Journal of India
Background: The transition of human immunodeficiency virus (HIV) infection to acquired immune deficiency syndrome (AIDS) has begun in India, and an increase in AIDS-related hospitalizations and deaths is an anticipated challenge. We estimated the rates of hospitalization and inpatient care...

Adult botulism type F in the United States, 1981-2002

Post Date: 
2005-12-13
Publication: 
Neurology
Background: Clostridium botulinum neurotoxin types A, B, and E cause most cases of the paralytic disease botulism. Little is known about the epidemiology, clinical features, or microbiology of botulism type F. Methods: Cases of adult type F botulism were identified by...

Necrotizing enterocolitis associated with Clostridium perfringens type A in previously healthy North-American adults

Post Date: 
2005-07-15
Publication: 
Journal of the American College of Surgeons
Background: Necrotizing enteritis associated with Clostridium perfringens type C ("pigbel") is a well-known syndrome in severely protein-deprived populations in the Pacific. It is exceedingly rare in the developed world. C perfringens type A is a common cause of acute gastroenteritis and, in a...

Antimicrobial-resistant Shigella sonnei: Limited antimicrobial treatment options for children and challenges of interpreting in vitro azithromycin susceptibility

Post Date: 
2005-06-15
Publication: 
Journal of Pediatric Infectious Diseases
Background: Antimicrobial-resistant Shigella sonnei is a growing problem in the United States and poses treatment challenges particularly among children. Azithromycin is recommended as an alternative oral agent for shigellosis. Methods: All isolates of Shigella...

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