COVID-19

Rationale: Scalable, inexpensive point-of-care (PoC) technologies that enable detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus are desperately needed. However, understanding the accuracy and usability of novel PoC technologies for SARS-CoV-2 is critical. Each PoC...

RADx Tech COVID-19 Test Us Bank

Post Date:

2020-08-05

Countries:

This study is collecting and storing lab samples of COVID-19 diagnostic tests among both people who have tested positive for COVID and those who haven’t to evaluate new COVID test and study how COVID-19 and related viruses cause disease in people.

RADx Tech COVID-19 Test Us Study

Post Date:

2020-07-27

Countries:

Scalable, inexpensive novel technologies that enable detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus are desperately needed. However, understanding the accuracy and usability of novel technologies for SARS-CoV-2 is critical. Each novel test needs to be evaluated...

Epidemiology and Clinical Outcomes of COVID-19 in India (ECO-19)

Post Date:

2020-07-09

Countries:

Clinical Sites:

This study was terminated May 25, 2021 This is a prospective cohort study of adults with suspected COVID-19 to address key knowledge gaps in the epidemiology of disease severity and poor clinical outcomes in India. Results from this study may help clinicians in India focus limited health resources...

Real-World Effectiveness Of Remdesivir In Adults Hospitalized With COVID-19: A Retrospective, Multicenter Comparative Effectiveness Study

Post Date:

2022-08-24

Publication:

Clinical Infectious Disease

Background There is an urgent need to understand the real-world effectiveness of remdesivir in the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods This was a retrospective comparative effectiveness study. Individuals hospitalized in a large private healthcare...

High-Intensity Versus Standard Thromboprophylaxis Among Adults Hospitalized with COVID-19: A Retrospective Cohort Study

Post Date:

2022-07-22

Countries:

Publication:

Research and Practice in Thrombosis and Haemostasis

Background and Objectives Current clinical guidelines recommend thromboprophylaxis for adults hospitalized with coronavirus disease 2019 (COVID‐19), yet it is unknown whether higher doses of thromboprophylaxis offer benefits beyond standard doses. Methods We studied electronic health records from...

Impact of SARS-CoV-2 variants on inpatient clinical outcome

Post Date:

2022-07-11

Countries:

Publication:

Clinical Infectious Diseases

Background Prior observation has shown differences in COVID-19 hospitalization risk between SARS-CoV-2 variants, but limited information describes hospitalization outcomes. Methods Inpatients with COVID-19 at 5 hospitals in the eastern United States were included if they had hypoxia, tachypnea,...

Burden of COVID-19 and Case Fatality Rate in Pune India: An Analysis of First and Second Wave of the Pandemic

Post Date:

2022-01-22

Countries:

Clinical Sites:

Publication:

IJID Regions

Objective To assess trends in case incidence and fatality rate between the first and second waves, we analyzed programmatic COVID-19 data from Pune city, an epicenter of COVID-19 cases in India. Method The trends of cases incidence, time-to-death and case fatality rate (CFR) were analyzed. Poisson...

Outbreak of Mucormycosis in Coronavirus Disease Patients, Pune, India

Post Date:

2021-09-29

Countries:

Clinical Sites:

Publication:

Emerging Infectious Diseases

Abstract We provide an overview of the epidemiology and clinical course of mucormycosis in the coronavirus disease (COVID-19) pandemic era. We conducted a retrospective chart review of 178 patients with clinical or diagnostic, endoscopically or histopathologically confirmed rhino-sino-orbital or...

Sex and gender differences in COVID testing, hospital admission, presentation, and drivers of severe outcomes in the DC/Maryland region

Post Date:

2021-08-31

Countries:

Publication:

medRxiv

Rates of severe illness and mortality from SARS-CoV-2 are greater for males, but the mechanisms for this difference are unclear.

A Case Study of Intra-Family Clustering of COVID-19 in India

Post Date:

2021-08-18

Countries:

Publication:

European Journal of Pharmaceutical and Medical Research

Background: With unprecedented COVID-19 disease-related morbidity and mortality globally, understanding the transmission dynamics of this disease is of paramount importance for disease control efforts. Despite the lockdown in India, there has been reported an ever-increasing number of infected...

Sex-biased clinical presentation and outcomes from COVID-19

Post Date:

2021-08-01

Publication:

Clinical Microbiology and Infection

Around the world, while males and females are equally likely to test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), males are significantly more likely to be hospitalized, to be admitted into intensive care units, and to die from coronavirus disease 2019 (COVID-19) [1,2...

Delayed rise of oral fluid antibodies, elevated BMI, and absence of early fever correlate with longer time to SARS-CoV-2 RNA clearance in a longitudinally sampled cohort of COVID-19 outpatients

Post Date:

2021-04-16

Publication:

Open Forum Infectious Diseases

Background Sustained molecular detection of SARS-CoV-2 RNA in the upper respiratory tract (URT) in mild to moderate COVID-19 is common. We sought to identify host and immune determinants of prolonged SARS-CoV-2 RNA detection. Methods Ninety-five outpatients self-collected mid-turbinate nasal,...

Comparison of Time to Clinical Improvement With vs Without Remdesivir Treatment in Hospitalized Patients With COVID-19

Post Date:

2021-03-24

Countries:

Publication:

JAMA Network Open

Just Published in JAMA Network Open: In this retrospective analysis, remdesivir was associated with faster clinical improvement of COVID-19 in a cohort of predominantly non-White patients

Development of Severe COVID-19 Adaptive Risk Predictor (SCARP), a Calculator to Predict Severe Disease or Death in Hospitalized Patients With COVID-19

Post Date:

2021-03-02

Publication:

Annals of Internal Medicine

Dr. Matt Robinson and colleagues developed a real-time tool that can predict severe disease or death among COVID patients

The clinical course of COVID-19 in the outpatient setting: a prospective cohort study

Post Date:

2021-01-05

Publication:

Open Forum Infectious Diseases

Background Outpatient coronavirus disease 2019 (COVID-19) has been insufficiently characterized. To determine the progression of disease and determinants of hospitalization, we conducted a prospective cohort study. Methods Outpatient adults with positive reverse transcription polymerase chain...

The burden of anxiety among people living with HIV during the COVID-19 pandemic in Pune, India

Post Date:

2020-10-23

Countries:

Publication:

BMC Public Health

Introduction: Globally, India has the third largest population of people living with HIV (PLHIV) and the second highest number of COVID-19 cases. Anxiety is associated with antiretroviral therapy (ART) nonadherence. It is crucial to understand the burden of anxiety and its sources among Asian...

Patient Trajectories Among Persons Hospitalized for COVID-19: A Cohort Study

Post Date:

2020-09-22

Countries:

Publication:

Annals of Internals Medicine

Risk factors for progression of coronavirus 2019 (COVID-19) to severe disease or death are underexplored in U.S. cohorts.

Mental health and quality of life among healthcare professionals during the COVID-19 pandemic in India

Post Date:

2020-09-11

Countries:

Publication:

Brain and Behavior

Background: The COVID-19 pandemic has placed healthcare professionals (HCP) in stressful circumstances with increased patient loads and a high risk of exposure. We sought to assess the mental health and quality of life (QoL) of Indian HCPs, the fourth highest-burden country for COVID-19. Method:...

Impact of Nationwide and Regional Lockdowns on Incident COVID-19 Cases in Pune City, India

Post Date:

2020-06-16

Countries:

Clinical Sites: