All Studies/Projects

Shorter Treatment for Minimal TB in Children (SHINE)

Post Date: 
2017-01-17
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated effective 5/29/2022 This is a multicountry study being conducted in India, South Africa, Uganda, and Zambia. The principal objective is to determine whether the standard 6 month regimen (8 weeks HRZ(E) followed by 16 weeks HR) can be reduced with similar efficacy, to 4...

Healthcare-Associated Sepsis in the Neonatal Intensive Care Unit in Pune, India

Post Date: 
2017-01-17
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
DY Patil
This study is part of CDC's Safe Healthcare, Epidemiology, and Prevention Research Development (SHEPheRD) Program under Domain 7: International HAI and Other Adverse Healthcare Event Prevention. Johns Hopkins neonatologist Dr. Julia Johnson is lead investigator for a systematic study of the...

Bacterial Antimicrobial Resistance Patterns in Pune, India: Substudy on the Introduction of Triage to a Triage Naïve Emergency Department in Pune, India, and the Effects on Patient Flow

Post Date: 
2017-01-01
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Despite state-of-the-art inpatient facilities, Sassoon General Hospital (SGH) in Pune, India, does not currently have a method of triaging the large volume of patients they care for on a daily basis. Based on prior studies in low to middle income countries...

Prevalence and Risk Factors for Oral Cancer among HIV-Infected Adults

Post Date: 
2016-12-13
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated effective 8/26/22 The study is designed as a cross-sectional, single time point study for opportunistic oral cancer screening of HIV-infected and non- HIV adults 21 years or older in an urban hospital. All participants will undergo screening for oral cancer and oral...

Cost-effectiveness of Xpert MTB/RIF for Diagnosing Pulmonary Tuberculosis in HIV-positive Patients

Post Date: 
2016-12-01
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated October 8, 2019. This is a prospective cross-sectional study which will be conducted at BJGMC in Pune, India. The aim of this study is to see whether Xpert MTB/RIF is useful for early detection of pulmonary tuberculosis, and therefore cost-effective, as compared with...

The Evaluation of Clinical Profile and Mortality of Children Admitted with Tuberculosis in Pediatric Intensive-Care Unit at Sassoon General Hospitals, Pune

Post Date: 
2016-10-27
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated October 27, 2019. Tuberculosis (TB) is one of the most common causes of infection-related death globally. TB was declared global public health emergency in 1993 by World HealthOrganization (WHO). Mortality due to TB is increasing due to emergence of multidrug resistant (...

Johns Hopkins University (JHU) HIV/AIDS management course in India

Post Date: 
2016-09-16
   |   
Countries: 
India
The Johns Hopkins University (JHU) HIV/AIDS Management Course in India is a CCGHE distance education initiative that aims to deliver a comprehensive continuing education program on adult HIV/AIDS clinical care. Lectures from leading experts are delivered online in a format that is accessible to...

Transcriptomic and Metabolomic Analysis of Microbiologically Confirmed Pediatric Tuberculosis Patients and Uninfected Household Contacts

Post Date: 
2016-09-01
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated in June 2020. This study is using stored samples from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB...

Establishing an Observational Cohort Database for Patient Care and Research at the Hinduja Hospital Chest Clinic

Post Date: 
2016-08-30
   |   
Countries: 
India
   |   
Clinical Sites: 
Hinduja Hospital
India has the largest burden of global tuberculosis (TB), accounting for one quarter of the total number of cases reported. Together with South Africa, India sees one-third of the total number of deaths from TB. Drug-resistant strains of the disease are also on the rise, with India having one...

Measuring TB Drugs in Hair as a Tool to Monitor Adherence, Exposure and Response in Patients with HIV

Post Date: 
2016-08-16
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
NIRT
Our study will examine whether hair levels of two key first line tuberculosis drugs will be useful markers to identify individuals at highest risk of treatment failure in active tuberculosis. Our study aims to provide a lowcost clinical tool using hair that can be noninvasively...

Adherence to Indian National Guidelines for Isoniazid Chemoprophylaxis among Pediatric Contacts of Pulmonary Tuberculosis Cases

Post Date: 
2016-07-06
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated June 19, 2019. The primary objective of the study was to assess the implementation of the Indian Revised National Tuberculosis Programme's (RNTCP) guidelines regarding isoniazid preventive treatment (IPT) for children under 6 years of age who had been in contact with...

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis: Nested Study on Temporal Dynamics of Gut Microbiota in HIV Infected Pregnant Women

Post Date: 
2016-07-05
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
NIRT
This is a nested prospective longitudinal cohort study of 35 HIV-infected and 35 HIV-noninfected pregnant women who are part of the parent study “Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis." The objectives are to: Determine the association...

Characterization of Findings on Upper Endoscopy in a Public Hospital in Pune, India

Post Date: 
2016-07-05
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated July 6, 2017. BJMC is the primary facility for non-emergency endoscopies for a large portion of Pune's underserved population. Currently, there is limited data on the endoscopic findings in resource-limited settings, where the population receiving endoscopic evaluation may...

A Randomized Therapeutic Interventional Comparative Study between Three Different Modalities of Paediatric Antitubercular Treatment

Post Date: 
2016-06-13
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated July 6, 2019. It was funded by the Fogarty International Center at the U.S. National Institutes of Health. This study evaluated three different TB treatment regimens in children attending Sassoon General Hospital in Pune, India. A...

Optimal Algorithmic Diagnosis of Genital TB among HIV-infected and Uninfected Infertile Women

Post Date: 
2016-05-26
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated March 2020. It was funded by the Fogarty International Center at the U.S. National Institutes of Health. There is a lack of a set protocol universally for diagnosis of genital TB, and for Indian hospitals, India's Revised National...

Whole Genome Sequencing and Trek Sensititre Testing of Stored Isolates of Drug-resistant Tuberculosis from a Clinical Cohort at Hinduja Hospital, Mumbai

Post Date: 
2016-05-02
   |   
Countries: 
India
   |   
Clinical Sites: 
Hinduja Hospital
Among HIV-positive TB patients presenting to Médecins San Frontières (MSF) clinics in Mumbai, 78% carried MDR-TB strains, with nearly half also found to have additional drug resistance. A previously published cohort of 202 patients cared for at these MSF clinics have enrolled in a...

Barriers to Early Treatment Initiation in Childhood Tuberculosis in High Incidence Setting

Post Date: 
2016-04-21
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated October 25, 2019. Funded by the Fogarty International Center and led by PI Dr. Chhaya Tukaram Valvi, the aim of this study is to evaluate the time to treatment initiation and barriers to early treatment initiation in childhood tuberculosis. TB...

Comparison of Available Purified-protein Derivative (PPD) Tuberculin Skin Test (TST) Antigen Solutions in Detecting Latent Tuberculosis Infection in India

Post Date: 
2016-04-21
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
NIRT
This study was terminated effective 12/23/2021 This study is conducted by the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH) under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB...

Barriers to Implementation of Isoniazid Preventive Treatment (IPT) in Pediatric Contacts of Sputum Positive Adults with Tuberculosis

Post Date: 
2016-03-24
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated January 3, 2019. It was funded by the Fogarty International Center at the U.S. National Institutes of Health. Young children infected with M.tuberculosis can rapidly progress to pulmonary and extrapulmonary disease with high rates of mortality and...

The Human Virome in Health and Disease

Post Date: 
2016-02-21
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Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated in September 2020. This study is part of the Antimicrobial Resistance study referenced below, Some samples were used from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional...

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