Publications by Year (2017)

Treatment of pulmonary tuberculosis

Post Date:

2017-04-27

Publication:

Handbook of Tuberculosis

This chapter addresses the treatment of pulmonary tuberculosis highlighting drug classes, recommended regimens, adverse drug reactions, drug-drug interactions, and practical aspects of monitoring, The principles of treatment of latent tuberculosis are also addressed including whom to treat,...

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Clinical features and diagnosis of tuberculosis: primary infection and progressive pulmonary tuberculosis

Post Date:

2017-04-27

Publication:

Handbook of Tuberculosis

In this chapter, we will review the clinical manifestations of intrathoracic tuberculosis (TB), including pathophysiology and clinical features of primary and secondary or reactivation TB. Specific topics discussed are the physical examination, and microbiological, radiological, and...

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High burden of antimicrobial resistance and mortality among adults and children with community-onset bacterial infections in India

Post Date:

2017-04-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

Journal of Infectious Diseases

Of 133 isolates from 115 patients, 50% were multi-drug resistant; of 33 isolates tested for carbapenem susceptibility, 36% were resistant.

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Resident doctors' attitudes toward tuberculosis patients

Post Date:

2017-04-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

Indian Journal of Tuberculosis

Background: The attitude of the resident doctors toward tuberculosis (TB) patients can affect their treatment seeking behavior, compliance to treatment as well as reinforce the stigma attached to the disease by the society at large. Aims: To assess the attitudes...

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Novel interferon-gamma assays for diagnosing tuberculosis in young children in India

Post Date:

2017-04-01

Countries:

India

Clinical Sites:

BJGMC

Publication:

International Journal of Tuberculosis and Lung Disease

Setting: The tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used as supportive evidence to diagnose active tuberculosis (TB). Novel IGRAs could improve diagnosis, but data are lacking in young children. Design: Children (age 5 years or...

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Reducing uncertainty for acute febrile illness in resource-limited settings: the current diagnostic landscape

Post Date:

2017-03-27

Publication:

The American Journal of Tropical Medicine and Hygiene

After decades of slow progress in diagnostics for acute febrile illness in resource-limited settings, a wave of converging advancements will enable clinicians in resource limited settings to reduce uncertainty for the diagnosis of acute febrile illness.

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The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

Post Date:

2017-03-24

Publication:

The Lancet Respiratory Medicine

Global tuberculosis incidence has declined marginally over the past decade, and tuberculosis remains out of control in several parts of the world including Africa and Asia. Although tuberculosis control has been effective in some regions of the world, these gains are threatened by the increasing...

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High prevalence of cryptococcal antigenaemia amongst asymptomatic advanced HIV patients in Pune, India

Post Date:

2017-03-21

Countries:

India

Clinical Sites:

BJGMC

Publication:

Indian Journal of Medical Microbiology

Methods : A prospective study was conducted in a large public sector ART centre and the inpatient wards of Sassoon Hospital, Pune, India. All consenting patients> 18 years of age with CD4 count <100 cells/mm3 were screened for CrAg by latex agglutination assay. Those with positive CrAg...

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Drug-resistant tuberculosis in 2017: at a crossroads

Post Date:

2017-03-15

Publication:

Lancet Respiratory Medicine

In The Lancet Respiratory Medicine, Dheda and colleagues present one of the most comprehensive pictures to date of the global epidemic of drug-resistant tuberculosis. This comes at a time of increasing awareness of antimicrobial resistance as a global threat, and Mycobacterium tuberculosis...

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Modelling approaches for tuberculosis: are they realistic?

Post Date:

2017-03-01

Countries:

India

Publication:

The Lancet Global Health

Letter by Dr. Sachin Atre in The Lancet Global Health.

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Vitamin A and D deficiencies associated with incident tuberculosis in HIV-infected patients initiating antiretroviral therapy in multinational case-cohort study

Post Date:

2017-02-06

Countries:

Publication:

Journal of Acquired Immune Deficiency Syndromes

Introduction: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral (ART) initiation in HIV-infected individuals is not well characterized. ...

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Tuberculosis associated with HIV infection

Post Date:

2017-01-15

Publication:

Microbiology Spectrum

Abstract Tuberculosis (TB) has recently surpassed HIV as the primary infectious disease killer worldwide, but the two diseases continue to display lethal synergy. The burden of TB is disproportionately borne by people living with HIV, particularly where HIV and poverty...