Nikhil Gupte, PhD

Pune, India
Role: 
Staff
Deputy Director, BJGMC Clinical Research Site

Dr. Gupte is Deputy Director of the BJGMC-JHU Clinical Research Site, a collaborative research partnership associated with the world’s largest HIV therapeutic trials networks, the AIDS Clinical Trials Group (ACTG) and the International Maternal Pediatric and Adolescent AIDS Clinical Trial Network (IMPAACT). He is also the Director of Data Management and Biostatistics for the center.

Dr. Gupte has more than 20 years of experience in public health research in developing countries and is a recognized leader in biostatistics education in India. Based in Pune, India, Dr. Gupte is the lead statistician for the BJGMC-JHU CRS, which conducts Phase I, II and III clinical trials of therapeutic drug interventions for HIV and co-morbid infections, such as tuberculosis and hepatitis, in adults (including pregnant women) and children. An experienced educator, Dr. Gupte has developed and taught biostatistics courses in India, including a number of University courses and NIH-supported training courses, and he currently leads the Biostatistics training for the BJGMC-JHU Fogarty HIV-TB Training Program.

A recipient of the Hopkins Fogarty fellowship, Dr. Gupte received a PhD in biostatistics from the Johns Hopkins Bloomberg School of Public Health.

Low sensitivity of total lymphocyte count as a surrogate marker to identify antepartum and postpartum Indian women who require antiretroviral therapy

Post Date: 
2007-11-01
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Background: Some studies support the use of total lymphocyte count (TLC) as a surrogate marker for CD4 cell count to guide antiretroviral therapy (ART) initiation. However, most of these studies have focused on nonpregnant adults. In light of expanding ART access through prevention of mother-...

Declining HIV Incidence among patients attending sexually transmitted infection clinics in Pune, India

Post Date: 
2007-08-15
   |   
Countries: 
India
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objective: A recent report suggesting declining HIV transmission rates in southern India has been based on HIV seroprevalence data to estimate HIV incidence. We analyzed HIV incidence rates among 3 cohorts (male, female non-sex worker, female sex worker [FSW]) presenting to sexually...

Declining HIV infection rates among recently married, pregnant women in Pune, India

Post Date: 
2007-08-15
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Background: A single recent study has suggested a decrease in HIV risk for women attending antenatal clinics (ANCs) in southern India. Yet, some have questioned the validity of the Indian national surveillance data and analyses. Previous studies suggest that the only major HIV risk factor for...

Mother-to-child transmission of HIV among women who chose not to exclusively breastfeed their infants in Pune, India

Post Date: 
2007-08-15
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
Indian Journal of Medical Research
Background and Objective: The percentage of HIV cases attributed to mother-to-child transmission (MTCT) has increased several fold in recent years. No reports are available on HIV MTCT rates among HIV-infected choosing not be exclusively breastfeed their infants in India. We examined HIV MTCT...

Clinically significant anemia in HIV-infected pregnant women in India is not a major barrier to zidovudine use for prevention of maternal-to-child transmission

Post Date: 
2007-06-01
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Objectives: To determine the prevalence of anemia (serum hemoglobin <10 g/dL) and assess zidovudine use and toxicity in HIV-positive pregnant women in India. Methods: From 2002 through 2006, 24,105 pregnant women in Pune were screened for HIV and anemia. As part of...

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