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T Cell Biomarkers and T-regulatory Responses to Pediatric TB
The goals of this study are to:
- Validate host T cell biomarkers for diagnosis of pediatric TB
- Investigate the phenotype and functions of T-regulatory cells in pediatric TB
We will use cryopreserved PBMC samples from CTRIUMPH cohorts: Pediatric unconfirmed TB, confirmed TB, latest Tb, and no TB controls. We will also leverage data and specifimens from the RePORT International coordinatoing Centre Pediatric Diagnostic Cohort study at BJGMC, Pune, and analyze PBMCs isolated from pediatric suspected TB cases.