Mandar Paradkar, MBBS, DCH, MPH

Pune, India
Role: 
Staff
Senior TB Research Manager
Mandar Paradkar, MBBS, DCH, MPH

Dr. Paradkar is Senior TB Research Manager and Study Coordinator for Johns Hopkins Center for Infectious Diseases in India (JH-CIDI), and is based at the Byramjee Jeejeebhoy Government Medical College-Johns Hopkins University Clinical Research Site (BJGMC-JHU-CRS) in Pune, India. He coordinates the Regional, Prospective, Observational Research in Tuberculosis (RePORT India) studies at the site including: Tuberculosis Research by the Indo-US Medical Partnership (CTRIUMPh) and its several ongoing biomarker substudies, the phase 1 and 2 Common protocol, RICC Pediatric Transcriptomic study (Co-PI); and he was part of TBM Kids clinical trial and its substudies. He is also currently coordinating the Genome Wide Analysis Study (RO1, GWAS, Emory University); the quantiferon study among household contacts of TB patients; the CATALYST (UNITAID) trial studying new child friendly formulations of moxifloxacin and clofazimine; and upcoming phase 1 pediatric trial of pretomanid (P2034, IMPAACT). He is currently the RePORT India Operations Working Group Chair and Junior Investigator in the consortium. He is a pediatrician by training and successfully completed the full time Master of Public Health degree through Cardiff University, UK, under the prestigious Commonwealth Scholarship Program in November, 2015. He rejoined the site in the role of study coordinator in December 2015.

In his current role, he coordinates the activities of aformentioned adult and pediatric TB study teams at the site. These activities involve regulatory documentation and reporting, recruitment of participants, ensuring the conduct of study procedures are in accordance with the study protocol, staff training, QC procedures, and regular communication with the CRS leadership, study laboratories, BJGMC faculty, local authorities for National TB Elemination Programme (NTEP) and the protocol teams on relevant subjects. His research interests are clinical epidemiology of pediatric TB, TBM, HIV-TB co-infection. He has been involved in 3 first-authored and several co-authored publications till date (https://pubmed.ncbi.nlm.nih.gov/?term=Mandar+Paradkar&sort=pubdate).

He completed his medical education in 2007 followed by pediatric post-graduation in 2009, and he worked as a pediatric intensive care registrar at Deenanath Mangeshkar Hospital, a tertiary care hospital in Pune till 2010. He then joined the BJMC-CRS in 2010 and worked for four years as a pediatric research clinician for various HIV studies, including the PROMISE study under NIH’s IMPAACT trial network. He also assisted in adult cryptococcal meningitis study under NIH’s ACTG trial network.

Dr. Paradkar was selected as the New Investigator awardee for 2011-12 by the IMPAACT network and received mentorship during the award year by Dr. Charles Mitchel (US based IMPAACT investigator). This award included participation on a network protocol development team (Dose finding, safety, and tolerance study of Raltegravir containing antiretroviral therapy in children), participation on the IMPAACT HIV complications scientific committee, and a grant award for research or training purposes. Dr. Paradkar completed the Clinical Vaccine Trials and Good Clinical Practice certificate course from Johns Hopkins University, attended the annual IMPAACT network meetings in Washington, DC, in 2011 and 2012.

Childhood ‘Omics’ and Mycobacterium tuberculosis-derived BiOsignatures (COMBO) for TB diagnosis

Post Date: 
2021-10-18
   |   
Countries: 
   |   
Clinical Sites: 
The overall objective of the project is to identify Mtb- and/or host-derived biosignatures in children that can achieve World Health Organization (WHO) target product profile (TPP) accuracy thresholds for a non-sputum biomarker-based triage or diagnostic test for childhood TB. We hypothesize that...

Epidemiologic Factors Associated with TB Treatment Outcomes Across Report International Consortia

Post Date: 
2021-08-12
   |   
Rationale: RePORT International was designed to enable cross-consortium data analysis. Now that a large number of consortium sites have completed participant enrollment in Common Protocol Cohort A, we can proceed with large-scale analysis of aligned RePORT data. The current study will harmonize and...

The Pharmacokinetics, Safety and Acceptability of New Child-Friendly Formulations of Clofazimine and Moxifloxacin in Children Routinely Treated for Rifampicin-Resistant Tuberculosis (CATALYST)

Post Date: 
2021-04-26
   |      |   
Clinical Sites: 
PK, safety and acceptability data and practical guidance on the optimal dosing of new more child-friendly formulations of moxifloxacin and clofazimine in children are urgently needed to inform their current and future use in children with Rifampicin-Resistant TB (RR-TB). Both medications have a key...

Dynamics and immune mechanisms of QFT response in close contacts of TB cases

Post Date: 
2021-04-05
   |   
Countries: 
   |   
Clinical Sites: 
Rationale: A vaccine that prevents infection with Mycobacterium tuberculosis (Mtb) (POI vaccine) is an ideal approach to TB control. As Mtb infection (MTBI) is measured indirectly (positive tuberculin skin test (TST) or interferon gamma release assay (IGRA), prevention of IGRA conversion is the...

A Nanopore Biosensor for Leveling MTB Antigens in Blood

Post Date: 
2021-04-01
   |   
Countries: 
   |   
Clinical Sites: 
Purpose of the study: The inability to obtain diagnostically useful sputum specimens, or the inability to analyze non-sputum specimens, is a significant contributor to poor diagnostic sensitivity of current TB assays, leading to the WHO to call for the development of non-sputum-based biomarker or...

Identification of Biomarkers That Can Predict Progression from Latent Tuberculosis Infection to Active Tuberculosis Disease

Post Date: 
2020-08-23
   |   
Countries: 
   |   
Clinical Sites: 
Purpose: The C-TRIUMPH study has identified 20 household contacts (HHC), who have progressed to active TB from its HHCs cohort (Cohort B). Immunological profiling of TB antigen induced biosignatures, profiling of transcriptional and proteomic biosignatures should provide novel insights into the...

Markers of Lung Impairment in HIV-TB Coinfected Indian Adults

Post Date: 
2019-12-11
   |   
Countries: 
   |   
Clinical Sites: 
Objectives/Aims We will compare the degree of lung impairment between HIV-TB co-infected adults (HIV-TB group) and TB cases without HIV co-infection (TB group) who successfully complete TB therapy. We hypothesize that the HIV-TB group will have a greater degree of lung...

T Cell Biomarkers and T-regulatory Responses to Pediatric TB

Post Date: 
2019-11-21
   |   
Countries: 
   |   
Clinical Sites: 
The goals of this study are to: Validate host T cell biomarkers for diagnosis of pediatric TB Investigate the phenotype and functions of T-regulatory cells in pediatric TB We will use cryopreserved PBMC samples from CTRIUMPH cohorts: Pediatric unconfirmed TB, confirmed TB, latest Tb, and no TB...

Inflammasome Genetics and Tuberculosis Treatment Outcomes

Post Date: 
2019-11-07
   |   
Countries: 
   |   
Clinical Sites: 
Dr. Amita Gupta is a Co-PI on this study. STUDY DESIGN We will conduct a retrospective case-cohort study nested within the CTRIUMPH and EDOTS cohorts to address our study objectives. This will enable us to measure the association of polymorphisms with multiple clinical outcomes simultaneously and...

Evaluation of a Urinary Biomarker Assay for Diagnosis and Test of Cure for Tuberculosis

Post Date: 
2019-09-09
   |   
Countries: 
   |   
Clinical Sites: 
Dr. Jeff Tornheim is PI of this study. METHODS This study will make use of biorepository samples from the Cohort for TB Research by the Indo-US Medical Partnership (CTRIUMPh). CTRIUMPh, funded by the US NIH and Indian Department of Biotechnology, is an academic collaboration between Johns Hopkins...

Characterization of Genomics and Metabolomics among Individuals Highly-Exposed, but Resistant to MTB Infection

Post Date: 
2018-12-13
   |   
Countries: 
   |   
Clinical Sites: 
New study launched in India & South Africa to identify functional relationships between genomics & metabolomics, & to characterize fundamental biological systems underlying resistance to Mtb infection.

Host RNA Expression for Diagnosis and Monitoring of Pediatric TB in Africa and India

Post Date: 
2018-12-13
   |   
Countries: 
   |   
Clinical Sites: 
We are leveraging the RePORT platform by including a cohort of Indian children together with South African children in a large validation study to study on changes in gene expression profiles during treatment for TB

Immune Responses and Effect of Disulfiram on MTB Infected PBMCs as a Potential Host Directed Therapy

Post Date: 
2018-11-26
   |   
Countries: 
   |   
Clinical Sites: 
Dr. Mandar Paradkar is lead investigator for this study that is assessing the immune responses of adult pulmonary TB patients enrolled in the CTRIUMPh study, using PBMC samples of those with harmful use of alcohol assessed by AUDIT scores ≥ 8 compared to non-alcoholics (AUDIT < 8). Aim 1: To...

Validating a Novel Functional Correlate of Immune Protection of Tuberculosis

Post Date: 
2018-10-03
   |   
Countries: 
   |   
Clinical Sites: 
This C-TRIUMPH study is a longitudinal assessment of PBMC samples of progressors and non-progressors among adult household contacts of active TB patients. The purpose of the study is to probe the functional diversity of T cell responses to several of the antigens encoded by Mtb simultaneously in...

Assessing Psychological Distress among Tuberculosis Patients and Their Household Members

Post Date: 
2018-07-17
   |   
Countries: 
   |   
Clinical Sites: 
By assessing psychological distress, Indo-JHU researchers hope to better understand the correlation between depression and TB severity.

Molecular Signatures of Tuberculosis-Diabetes Interaction: Metabolomics Study

Post Date: 
2018-06-15
   |   
Countries: 
   |   
Clinical Sites: 
This study is using stored samples from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Type 2 diabetes mellitus (DM...

Molecular Signatures of Tuberculosis-Diabetes Interaction: Transcriptomics Study

Post Date: 
2018-06-15
   |   
Countries: 
   |   
Clinical Sites: 
This study is using stored samples from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Type 2 diabetes is an...

The Role of Innate Immunity in the Acquisition of Sterile Protection against TB Infection

Post Date: 
2017-08-25
   |   
Countries: 
   |   
Clinical Sites: 
This study is using stored samples from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Tuberculosis (TB) is a major...

Validation of Transcriptional Signature to Predict Active TB Disease among Advanced HIV Patients

Post Date: 
2017-08-15
   |   
Countries: 
   |   
Clinical Sites: 
This study was terminated June 20, 2021. There have been tremendous advances in the diagnosis of patients with tuberculosis (TB) based on nucleic acid amplification of bacteria in the sputum. The GenXpert MTB/RIF provides results in 2 hours. However, in HIV-infected sputum...

Biomarkers for Tuberculosis Diagnosis and Treatment Response

Post Date: 
2017-03-24
   |   
Countries: 
   |   
Clinical Sites: 
This study is conducted by the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH) under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Aims: ...

Pages

Concomitant pulmonary disease is common among patients with extrapulmonary TB

Post Date: 
2022-08-12
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
International Journal of Tuberculosis and Lung Disease
Dr. Shivakumar and his group discovered that a high proportion of patients classified as EPTB in India have concomitant PTB. Their results support the need for improved symptom and CXR screening, and recommends routine sputum TB microbiology screening of all Indian patients with EPTB.

Baseline IL-6 is a biomarker for unfavorable tuberculosis treatment outcomes: a multi-site discovery and validation study

Post Date: 
2021-11-08
Publication: 
The European Respiratory Journal
Dr. Akshay Gupte and colleagues discovered that elevated IL-6 can predict poor treatment outcomes, showcasing a need for including IL-6 in clinical screenings.

Unhealthy alcohol use independently associated with unfavorable TB treatment outcomes among Indian men

Post Date: 
2021-03-10
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
International Journal of Tuberculosis and Lung Disease
This study by Samyra Cox and colleagues highlights the need for integrating effective alcohol interventions into TB care.

Measuring TB drug levels in the hair in adults and children to monitor drug exposure and outcomes

Post Date: 
2021-01-01
   |   
Countries: 
Publication: 
International Journal of Tuberculosis and Lung Disease
INTRODUCTION: Testing for anti-TB drugs in small hair samples may serve as a non-invasive tool to measure cumulative drug exposure and/or adherence, as these determine treatment success. We aimed to assess how well hair assays of TB drugs predict TB treatment outcomes.METHODS: A small thatch of...

Integration of metabolomics and transcriptomics reveals novel biomarkers in the blood for tuberculosis diagnosis in children

Post Date: 
2020-11-11
   |   
Countries: 
Publication: 
Scientific Reports
Pediatric tuberculosis (TB) remains a major global health problem. Improved pediatric diagnostics using readily available biosources are urgently needed. We used liquid chromatography-mass spectrometry to analyze plasma metabolite profiles of Indian children with active TB (n = 16) and age- and sex...

Assessment of persistent depression among TB patients

Post Date: 
2020-11-01
   |   
Countries: 
Publication: 
International Journal of Tuberculosis and Lung Disease
(No abstract available)

Tuberculosis preventive treatment should be considered for all household contacts of pulmonary tuberculosis patients in India

Post Date: 
2020-07-29
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
PLoS One
PLoS One: Dr. Mandar Paradkar and colleagues conducted a CTRIUMPH study that supports TB preventive therapy for all household contacts of pulmonary TB patients in India

Mullen Scales of Early Learning Adaptation for Assessment of Indian Children and Application to Tuberculous Meningitis

Post Date: 
2020-07-04
   |   
Countries: 
Publication: 
Journal of Tropical Pediatrics
Introduction: Tuberculous meningitis (TBM) results in significant morbidity and mortality among children worldwide. Associated neurocognitive complications are common but not well characterized. The Mullen Scales of Early Learning (MSEL), a well-established measure for assessment of...

Transcriptomic profiles of confirmed pediatric tuberculosis patients and household contacts identifies active tuberculosis, infection, and treatment response among Indian children

Post Date: 
2019-12-04
   |   
Clinical Sites: 
Publication: 
Journal of Infectious Diseases
Journal of Infectious Diseases: Gene expression profiles among Indian children with confirmed TB were distinct from those of adults, highlighting the importance of including distinct populations in differential gene expression models

MAL adaptor (TIRAP) S180L polymorphism and severity of disease among tuberculosis patients

Post Date: 
2019-10-31
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
Infection, Genetics, and Evolution
Infection, Genetics, and Evolution : We investigated the association of TIRAP variants with severity of TB disease and IP-10 production in humans, which may be useful in predicting poor clinical outcome

Challenges in conducting trials for pediatric tuberculosis meningitis: lessons learned in the field

Post Date: 
2019-10-01
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
International Journal of Tuberculosis and Lung Disease
International Journal of Tuberculosis and Lung Disease: Researchers describe the challenges associated with conducting the first randomized clinical trial of antimicrobial agents in pediatric tuberculosis meningitis.

Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored

Post Date: 
2019-07-31
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
PLoS One
BACKGROUND: More than 20% of tuberculosis (TB) disease worldwide may be attributable to smoking and alcohol abuse. India is the second largest consumer of tobacco products, a major consumer of alcohol particularly among males, and has the highest burden of TB globally. The impact of...

Infection free "resisters" among household contacts of adult pulmonary tuberculosis

Post Date: 
2019-07-18
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
PLoS One
Despite substantial exposure to infectious pulmonary tuberculosis (TB) cases, some household contacts (HHC) never acquire latent TB infection (LTBI). Characterizing these "resisters" can inform who to study immunologically for the development of TB vaccines. We enrolled HHCs of culture-confirmed...

Age-specific prevalence of TB infection among household contacts of pulmonary tuberculosis: Is it time for TB preventive therapy?

Post Date: 
2019-06-21
   |   
Countries: 
Publication: 
Transactions of the Royal Society of Tropical Medicine and Hygiene
BACKGROUND: Household contacts (HHCs) of TB patients are at high risk of developing evidence of latent TB infection (LTBI) and active disease from the index patient. We estimated the age-specific prevalence of LTBI and the force of infection (FI), as a measure of recent transmission, among HHCs of...

Assessment of lung function in successfully treated tuberculosis reveals high burden of ventilatory defects and COPD

Post Date: 
2019-05-23
   |   
Countries: 
Publication: 
PLoS One
New in PLoS One: We found a high burden of lung function defects and COPD in tuberculosis cases who successfully completed treatment, suggesting a need for lung function screening as part of patient management.

Subtherapeutic rifampicin concentration is associated with unfavourable tuberculosis treatment outcomes

Post Date: 
2019-05-10
   |   
Countries: 
Publication: 
Clinical Infectious Diseases
Rifampicin concentrations were sub-therapeutic in most Indian patients taking a thrice-weekly TB regimen

The association of household fine particulate matter and kerosene with tuberculosis in women and children in Pune, India

Post Date: 
2018-09-07
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
Occupational and Environmental Medicine
Use of kerosene cooking fuel is positively associated with TB in women and children in our analysis using reported sources of exposure.

Tuberculin skin test and QuantiFERON-Gold In Tube assay for diagnosis of latent TB infection among household contacts of pulmonary TB patients in high TB burden setting

Post Date: 
2018-08-01
   |   
Countries: 
Publication: 
PLoS One
World Health Organization (WHO) recommends systematic screening of high-risk populations, including household contacts (HHCs) of adult pulmonary tuberculosis (TB) patients, as a key strategy for elimination of TB. QuantiFERON-TB Gold In-Tube (QFT-GIT) assay and tuberculin skin test (TST) are two commonly used tools for the detection of latent tuberculosis infection (LTBI) but may yield differential results, affecting eligibility for TB preventive therapy.

Diabetes and pre-diabetes among household contacts of tuberculosis patients in India: is it time to screen them all?

Post Date: 
2018-05-22
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
The International Journal of Tuberculosis and Lung Disease
Authors find that screening contacts of TB patients for pre-DM/DM and linking them to care may mitigate the risk of developing tuberculosis and improve management of diabetes.

Addressing knowledge gaps and prevention for tuberculosis-infected Indian adults: a vital part of elimination

Post Date: 
2018-05-02
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
BMC Infectious Diseases
BMC Infectious Diseases : Our survey among TB patients' household contacts with evidence of recent exposure found that knowledge is poor and families are confused about disease transmission.

India Revises National TB Prevention Guidelines Using Findings from Indo-JHU Research 

Post Date: 
2021-08-31
Source: 
CCGHE
TB graphic
“If we can screen patients early and get their household contacts on preventive therapy, we have an opportunity to stop the chain of this horrible disease.”

Study Shows Extent, Danger of TB Exposure: Part I

Post Date: 
2020-08-24
Source: 
Medical Daily
Medical Daily: Amita Gupta and Mandar Paradkar are quoted in this report about TB preventive therapy for household contacts of confirmed cases in India

Research Story Tip: International Johns Hopkins Study Says Broad Measures Needed to Prevent TB Spread in India

Post Date: 
2020-08-06
Dr. Mandar Paradkar
Johns Hopkins News Release: News release highlights study findings published in PLOS One by Dr. Mandar Paradkar and colleagues.

Broad measures needed to check spread of TB in India: Study

Post Date: 
2020-08-05
Source: 
daijiworld.com
daijiworld.com (India): Dr. Mandar Paradkar is quoted about his recent study on TB preventive therapy for household contact of TB cases.

Broad measures needed to check spread of TB in India, say researchers

Post Date: 
2020-08-05
Source: 
The Tribune (India)
Drs. Mandar Paradkar and Robert Bollinger are quoted in this article that highlights their recent paper about administration of TB preventive therapy for household contacts of confirmed TB cases in India.

World Tuberculosis (TB) Day Recognized with Community Event at BJGMC

Post Date: 
2018-04-17
This year's themes: Maintaining healthy nutrition, addressing mental health challenges, and the latest in TB research.

Women's Empowerment at BJGMC World TB Day 2017

Post Date: 
2017-04-03
Posted 2017-04-03

World AIDS Day 2016 at BJGMC

Post Date: 
2016-12-06
Read more about 2016 World AIDS Day activities at the BJGMC Clinical Site in Pune, India.

Advancing Global TB Research through RePORT

Post Date: 
2016-02-29
Regional Prospective Observational Research for Tuberculosis (RePORT) International is a large, international tuberculosis research effort being undertaken by 4 regional consortia: RePORT Brazil, RePORT South Africa, RePORT Indonesia, and RePORT India. While each region collects and maintains...