PRACHITI

Studies/Projects
Publications

Zika Surveillance among Antenatal Clinic Outpatients in BJ Government Medical College and Sassoon General Hospitals, Pune, India

Post Date:

2017-08-31

Countries:

Clinical Sites:

This study was terminated July 21, 2020. Zika virus is a vector-borne disease carried by the mosquito Aedes aegypti . Pregnant women infected with Zika may pass the virus to the fetus, which may cause microcephaly and other severe brain defects. It is also linked to...

Investigating Maternal Antibodies to Modify Infant Tuberculosis Acquisition

Post Date:

2017-08-29

Countries:

India

Clinical Sites:

BJGMC

New study in Pune, India, aims to identify the profile of TB antibodies between mothers and infants, and to see if the presence of antibodies lowers risk of infant infection.

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis: Nested Study on Temporal Dynamics of Gut Microbiota in HIV Infected Pregnant Women

Post Date:

2016-07-05

Countries:

India

Clinical Sites:

BJGMC

NIRT

This is a nested prospective longitudinal cohort study of 35 HIV-infected and 35 HIV-noninfected pregnant women who are part of the parent study “Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis." The objectives are to: Determine the association...

Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome and Preterm Birth

Post Date:

2014-10-28

Countries:

India

Clinical Sites:

BJGMC

NIRT

This study was terminated May 7, 2018. P regnancy is a state of relative immunosuppression in order to protect the fetus from being rejected. It has also been shown that the Th-1 helper cell response, which is normally necessary for overcoming TB infection...

Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis

Post Date:

2014-09-01

Countries:

India

Clinical Sites:

BJGMC

NIRT

This is the Parent Study for CCGHE’s PRACHITI (PRegnancy And CHanges In TuberculosIs) effort. It's supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the U.S. National Institutes of Health. Purpose: TB is a...

Impact of pregnancy and HIV on LTBI diagnostics and MTB-induced immune response: a cohort study in Pune, India

Post Date:

2022-11-01

Countries:

India

Publication:

International Journal of Infectious Diseases

Background Accurate tuberculosis infection (TBI) tests are critical for pregnant women, especially those with HIV, who have a high risk of TB disease. Methods We enrolled interferon gamma release assay (IGRA)+ pregnant women with and without HIV in a longitudinal study, followed up at delivery and...

Assessing tuberculosis risk in pregnant women from the PRACHITi study using transcriptomics

Post Date:

2022-06-10

Countries:

India

Publication:

Clinical Infectious Diseases

A new tuberculosis (TB) diagnostic cartridge assay, which detects a 3-gene TB signature in whole blood, was not diagnostic in women with maternal TB disease in India (area under the curve [AUC] = 0.72). In a cohort of pregnant women, we identified a novel gene set for TB diagnosis (AUC = 0.97) and...

TB-related Knowledge and Stigma Among Pregnant Women in Low Resource Settings of Pune, India

Post Date:

2022-02-01

Countries:

Haiti

Clinical Sites:

BJGMC

Publication:

The International Journal of Tuberculosis and Lung Disease,

TB is an important cause of maternal morbidity.1 Studies among adults with TB in several countries have consistently demonstrated that a lack of TB-related knowledge and increased stigma can be a barrier to early diagnosis, seeking treatment and treatment adherence.2–6 India has the highest number...

Immunologic effects of pregnancy on M. tuberculosis: methodology of an observational cohoStages of pregnancy and HIV affect diagnosis of tuberculosis infection and Mycobacterium tuberculosis (MTB)-induced immune response: Findings from PRACHITi, a cohort

Post Date:

2021-09-21

Publication:

International Journal of Infectious Diseases

Stages of pregnancy and HIV affect diagnosis of tuberculosis infection and Mycobacterium Tuberculosis (MTB)-induced immune response: Findings from PRACHITi, a cohort study in Pune, India

Post Date:

2021-01-11

Countries:

India

Publication:

IJID

Intensified short symptom screening program for Dengue infection during pregnancy, India

Post Date:

2020-04-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

Emerging Infectious Diseases

Mosquitoborne diseases (e.g., malaria, dengue, and chikungunya) are endemic to India and pose diagnostic challenges during pregnancy. We evaluated an intensified short symptom screening program in India to diagnose dengue during pregnancy. During October 2017-January 2018, we screened pregnant...

TB prevention strategies and unanswered questions for pregnant and postpartum women living with HIV: the need for improved evidence

Post Date:

2020-03-23

Publication:

Journal of the International AIDS Society

World TB Day viewpoint on the need for more data about TB treatment for pregnant and postpartum women in J Int AIDS Soc by Drs. Jyoti Mathad and Amita Gupta.

Inclusion of key populations in clinical trials of new antituberculosis treatments: Current barriers and recommendations for pregnant and lactating women, children, and HIV-infected persons

Post Date:

2019-08-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

PLOS Medicine

PLOS Medicine: Dr. Amita Gupta and colleagues discuss the scientific and ethical basis for including pregnant and lactation women, children, and HIV+ patients in tuberculosis therapeutic clinical trials.

Symptom screening for active tuberculosis in pregnant women living with HIV

Post Date:

2019-01-24

Publication:

Cochrane Database of Systematic Reviews

This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows: To assess the accuracy of the four-symptom screen (cough, fever, night sweats, or weight loss) for identifying active TB in pregnant PLHIV who are screened in an outpatient or community setting...

Is there a connection between gestational diabetes, human immunodeficiency virus infection, and tuberculosis?

Post Date:

2019-01-01

Countries:

India

Clinical Sites:

BJGMC

Publication:

International Journal of Tuberculosis and Lung Disease

IJTLD article reviews the epidemiology and immunology of gestational diabetes and finds there's a lot we don't know about interactions between diabetes, pregnancy, and tuberculosis in both HIV+/- women

Household food insecurity is associated with low interferon-gamma levels in pregnant Indian women

Post Date:

2017-07-01

Countries:

India

Clinical Sites:

BJGMC

Publication:

International Journal of Tuberculosis and Lung Disease

Objective: To determine the association between household food insecurity and interferon-gamma (IFN-γ) levels in pregnancy. Design: Pregnant women in India were administered the Household Food Insecurity Access Scale (HFIAS) questionnaire and underwent an IFN-γ release assay...

Pulmonary infections in pregnancy

Post Date:

2017-06-01

Publication:

Seminars in Respiratory and Critical Care Medicine

Clinical review from Drs. Amita Gupta & Jyoti Mathad on improving tuberculosis treatment outcomes for pregnant women.

Cost effectiveness of isoniazid preventive therapy for HIV-infected pregnant women in India

Post Date:

2016-01-01

Countries:

India

Clinical Sites:

BJGMC

Publication:

International Journal of Tuberculosis and Lung Disease

Background: India has a high burden of active tuberculosis (TB) and human immunodeficiency virus (HIV) infection. Pregnancy increases the risks of developing TB in HIV-infected women. Isoniazid preventive therapy (IPT) reduces progression to TB, but may increase costs and hepatotoxicity. The...