Jonathan Golub, MPH, PhD

Role:

Faculty

Professor of Medicine, Epidemiology, and International Health

Jonathan Golub, PhD, MPH brings more than 20 years of experience focusing on the epidemiology, detection, and prevention of TB in low and middle-income countries and the many drivers associated with TB acquisition, progression, and treatment outcomes. He is a Professor of Medicine, Epidemiology, and International Health at the Johns Hopkins Schools of Medicine and Public Health. He is experienced in developing and implementing research studies for TB in Brazil, South Africa and India, leading and managing large research teams in these countries.

Current NIH grants that he is leading include: implementation of a new test and treat strategy for latent TB infection among people with HIV in Brazil (PREVINE); an RCT comparing strategies for detecting recurrent TB among people who have completed TB treatment in India, and extent of pulmonary impairment at the end of TB treatment and beyond (TB Aftermath); an RCT comparing strategies for pulmonary rehabilitation for reducing pulmonary impairment among people with TB in India (TB PuRe); and an RCT comparing smoking cessation interventions among people with HIV in South Africa (Tlogela).

Previously, he has led smoking cessation studies and tobacco prevalence studies among people with HIV and people with TB patients in several LMICs and he has also investigated the impact of diabetes on TB outcomes in India. He is currently leading implementation research studies looking at novel ways to increase TB preventive therapy among HIV-infected patients in several African countries through Unitaid’s IMPAACT4TB.

He is currently the JHU Research Development Team Lead Investigator, overseeing the SMART4TB Technical Area teams at JHU and with partners for the USAID funded project. He has served on WHO expert panels for operational research and guideline development groups for developing TB screening guidelines. He is actively involved in Fogarty training grants in India and South Africa (currently site-PI with University of Witswatersrand) and was PI for 11 years for a Fogarty HIV/TB training program in Brazil, which was expanded to include trainees from Mozambique, India and Brazil. He is currently Director of the Developmental Core for the JHU Tuberculosis Research Advancement Center (TRAC). Finally, he has taught the Epidemiologic Basis for Tuberculosis Control at the Johns Hopkins Bloomberg School of Public Health for 18 years and has taught the course in South Africa, Brazil and India as well.

Studies/Projects
Publications

Assessing the Association of Indoor Air Pollution with Tuberculosis in Adult Women and Children under 5 Years of Age

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2013-09-15

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This study is conducted the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH) under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Addressing social and...

Impact of Diabetes on TB Treatment Outcomes

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2013-02-01

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CCGHE, the JHU Center for TB Research and BJGMC have been awarded a $2.5 million dollar NIH grant (2013-2018) to conduct a study to evaluate treatment outcomes among Indian patients with both diabetes mellitus and active TB. This study is assessing the prevalence of impaired glucose or frank...

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High risk for latent tuberculosis infection among medical residents and nursing students in India

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2019-07-08

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PLoS One

PLoS ONE: Self-reported TB exposure is underreported, and uptake of LTBI prevention therapy remains low

Mobile phone access and comfort: implications for HIV and tuberculosis care in India and South Africa.

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2019-07-01

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International Journal of Tuberculosis and Lung Disease

SETTING: India and South Africa shoulder the greatest burden of tuberculosis (TB) and human immunodeficiency virus (HIV) infection respectively, but care retention is suboptimal. OBJECTIVE: We conducted a study in Pune, India, and Matlosana, South Africa ...

Assessment of lung function in successfully treated tuberculosis reveals high burden of ventilatory defects and COPD

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2019-05-23

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PLoS One

New in PLoS One: We found a high burden of lung function defects and COPD in tuberculosis cases who successfully completed treatment, suggesting a need for lung function screening as part of patient management.

Subtherapeutic rifampicin concentration is associated with unfavourable tuberculosis treatment outcomes

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2019-05-10

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Clinical Infectious Diseases

Rifampicin concentrations were sub-therapeutic in most Indian patients taking a thrice-weekly TB regimen

Respiratory health status is associated with treatment outcomes in pulmonary tuberculosis

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2019-04-19

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The International Journal of Tuberculosis and Lung Disease

BACKGROUND: The association between respiratory impairment and tuberculosis (TB) treatment outcomes is not clear. METHODS: We prospectively evaluated respiratory health status, measured using the Saint George's Respiratory Questionnaire (SGRQ), in a cohort of new adult pulmonary TB cases during and...

Barriers to screening and isoniazid preventive therapy for child contacts of tuberculosis patients

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2018-10-01

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International Journal of Tuberculosis and Lung Disease

Universal, timely TB screening and IPT for exposed children are urgently needed to reduce pediatric TB in India

The association of household fine particulate matter and kerosene with tuberculosis in women and children in Pune, India

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2018-09-07

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Occupational and Environmental Medicine

Use of kerosene cooking fuel is positively associated with TB in women and children in our analysis using reported sources of exposure.

The effect of diabetes mellitus on the pharmacokinetics and pharmacodynamics of tuberculosis treatment

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2018-08-20

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Antimicrobial Agents and Chemotherapy

DM and higher HbA1c increased the risk of not achieving therapeutic targets for pyrazinamide, but higher pyrazinamide concentrations were asociated with worse microbiologic and clinical outcomes

Trends in HbA1c levels and implications for diabetes screening in tuberculosis cases undergoing treatment in India

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2018-07-01

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International Journal of Tuberculosis and Lung Disease

SETTING: The optimal timing of screening for diabetes mellitus (DM) among tuberculosis (TB) cases is unclear due to the possibility of stress hyperglycemia. DESIGN: We evaluated adult (18 years) pulmonary TB cases at treatment initiation as well as at 3 months,...

Loss to follow‐up and mortality among HIV‐infected adolescents receiving antiretroviral therapy in Pune, India

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2018-06-25

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HIV Medicine

Over 6 years, one-third of HIV+ adolescents in this study discontinued medical treatment, indicating a critical need for retention counselling and closer clinical monitoring.

Effect of baseline micronutrient and inflammation status on CD4 recovery post-cART initiation in the multinational PEARLS trial

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2018-05-29

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Clinical Nutrition

Nutritional deficiency and inflammation may impact CD4+ T cell recovery during combination antiretroviral therapy (cART), particularly in resource-limited settings where malnutrition is prevalent. The aim of this study was to investigate the relationship of micronutrient and inflammation biomarkers to CD4 recovery after cART initiation.

Sources of household air pollution and their association with fine particulate matter in low-income urban homes in India

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2018-05-23

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Journal of Exposure Science and Environmental Epidemiology

INTRODUCTION: Household air pollution (HAP) is poorly characterized in low-income urban Indian communities. MATERIALS AND METHODS: A questionnaire assessing sources of HAP and 24 h household concentrations of particulate matter less than 2.5 microns in diameter (...

Diabetes and pre-diabetes among household contacts of tuberculosis patients in India: is it time to screen them all?

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2018-05-22

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The International Journal of Tuberculosis and Lung Disease

Authors find that screening contacts of TB patients for pre-DM/DM and linking them to care may mitigate the risk of developing tuberculosis and improve management of diabetes.

Gender-based violence screening methods preferred by women visiting a public hospital in Pune, India

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2018-01-22

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BMC Womens Health

BMC Womens Health : In our study, 23% of women reported experiencing gender based violence, and 90% reported they had never been asked about it in the healthcare setting.

Secondhand smoke exposure and validity of self-report in low-income women and children in India

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2018-01-10

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Pediatrics

Pediatrics: Dr. Jessica Elf and colleagues evaluated the validity of standard self-reported measures for secondhand smoke (SHS) exposure among women and children in urban India.

Prevalence of dysglycemia and clinical presentation of pulmonary tuberculosis in Western India

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2017-12-01

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International Journal of Tuberculosis and Lung Disease

Objectives: To estimate the prevalence and risk factors of pre-diabetes mellitus (DM) and DM, and its associations with the clinical presentation of tuberculosis (TB). Design: Screening for DM was conducted among adults (age  18 years) with confirmed TB between December 2013 and...

Tuberculosis screening among persons with diabetes mellitus in Pune, India

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2017-06-02

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BMC Infectious Diseases

Background: Diabetes mellitus (DM) increases tuberculosis (TB) risk, and there is increasing concern over the public health implications of the convergence of these two epidemics. Screening for TB among people with DM is now recommended in India. Methods: People with DM seeking...

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