Jonathan Golub, MPH, PhD

Role:

Faculty

Professor of Medicine, Epidemiology, and International Health

Jonathan Golub, PhD, MPH brings more than 20 years of experience focusing on the epidemiology, detection, and prevention of TB in low and middle-income countries and the many drivers associated with TB acquisition, progression, and treatment outcomes. He is a Professor of Medicine, Epidemiology, and International Health at the Johns Hopkins Schools of Medicine and Public Health. He is experienced in developing and implementing research studies for TB in Brazil, South Africa and India, leading and managing large research teams in these countries.

Current NIH grants that he is leading include: implementation of a new test and treat strategy for latent TB infection among people with HIV in Brazil (PREVINE); an RCT comparing strategies for detecting recurrent TB among people who have completed TB treatment in India, and extent of pulmonary impairment at the end of TB treatment and beyond (TB Aftermath); an RCT comparing strategies for pulmonary rehabilitation for reducing pulmonary impairment among people with TB in India (TB PuRe); and an RCT comparing smoking cessation interventions among people with HIV in South Africa (Tlogela).

Previously, he has led smoking cessation studies and tobacco prevalence studies among people with HIV and people with TB patients in several LMICs and he has also investigated the impact of diabetes on TB outcomes in India. He is currently leading implementation research studies looking at novel ways to increase TB preventive therapy among HIV-infected patients in several African countries through Unitaid’s IMPAACT4TB.

He is currently the JHU Research Development Team Lead Investigator, overseeing the SMART4TB Technical Area teams at JHU and with partners for the USAID funded project. He has served on WHO expert panels for operational research and guideline development groups for developing TB screening guidelines. He is actively involved in Fogarty training grants in India and South Africa (currently site-PI with University of Witswatersrand) and was PI for 11 years for a Fogarty HIV/TB training program in Brazil, which was expanded to include trainees from Mozambique, India and Brazil. He is currently Director of the Developmental Core for the JHU Tuberculosis Research Advancement Center (TRAC). Finally, he has taught the Epidemiologic Basis for Tuberculosis Control at the Johns Hopkins Bloomberg School of Public Health for 18 years and has taught the course in South Africa, Brazil and India as well.

Studies/Projects
Publications
Scholars
News

Assessing prevalence and risk of lung morbidities including lung nodules and cancer using non contrast CT among PLHIV in Pune, India

Post Date:

2022-11-25

|

Countries:

|

Clinical Sites:

Primary objective Determine the prevalence of pulmonary nodules, including lung cancer using NCCT. Determine the risk of pulmonary nodules, including lung cancer using NCCT. Evaluate the association of smoking, immune suppression, ART, and TB with the prevalence and risk of NCCT-diagnosed pulmonary...

Epidemiology and Clinical Outcomes of COVID-19 in India (ECO-19)

Post Date:

2020-07-09

|

Countries:

|

Clinical Sites:

This study was terminated May 25, 2021 This is a prospective cohort study of adults with suspected COVID-19 to address key knowledge gaps in the epidemiology of disease severity and poor clinical outcomes in India. Results from this study may help clinicians in India focus limited health resources...

Tuberculosis (TB) Aftermath

Post Date:

2020-06-05

|

Countries:

|

Clinical Sites:

Drs. Vidya Mave and Jonathan Golub are co-PIs and Dr. Barthwal from DY Patil Medical College is local site PI for this study. TB Aftermath seeks to provide evidence for an effective and scalable strategy targeting HHs of treated TB cases, a high priority of the NTEP. Purpose To compare the...

Prevalence of Risk Factors for Lung Cancer and Facilitators and Barriers for Tobacco Cessation among People Living with HIV

Post Date:

2020-04-01

|

Countries:

|

Clinical Sites:

India has the world’s third largest HIV epidemic, with 2.1 million people currently living with HIV and an additional 90,000 new infections each year.[29] At the same time, expansion of the HIV response under India’s premier governmental agency - the National AIDS Control Organization (NACO), has...

Hybrid Trial for Alcohol Reduction among People with TB and HIV in India

Post Date:

2020-02-12

|

Countries:

|

Clinical Sites:

Dr. Geetanjali Chander is PI and Dr. Kakrani is local site PI at DY Patil Medical College for this study. The highest incidence of tuberculosis disease (TB) in the world is in India, accounting for 27% of all new cases globally, with approximately 86,000 among persons with HIV (PWH). Unhealthy...

Visual Field Loss in HIV-Positive Patients of Non-Infectious HIV Retinopathy

Post Date:

2019-06-02

|

Countries:

|

Clinical Sites:

New study will assess HIV+ patients and determine the prevalence of visual field loss due to noninfectious HIV retinopathy

Prevalence of Tuberculosis in Severely Malnourished Indian Children

Post Date:

2018-12-18

|

Countries:

|

Clinical Sites:

This study is funded and conducted under the U.S. National Institutes of Health, Fogarty International Center. PIs are Robert Bollinger, MD, MPH; Dr. Muralidhar Tambe, BJGMC Severely malnourished children are vulnerable population for communicable and non-communicable...

Molecular Signatures of Tuberculosis-Diabetes Interaction: Metabolomics Study

Post Date:

2018-06-15

|

Countries:

|

Clinical Sites:

This study is using stored samples from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Type 2 diabetes mellitus (DM...

Molecular Signatures of Tuberculosis-Diabetes Interaction: Transcriptomics Study

Post Date:

2018-06-15

|

Countries:

|

Clinical Sites:

This study is using stored samples from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Type 2 diabetes is an...

Assessing Tuberculosis Transmission Dynamics, Drug Resistance and Recurrence Using Whole Genome Sequencing in Pune, India

Post Date:

2018-06-12

|

Countries:

Indo-JHU researchers are using combined geospatial and genotyping methods to describe TB transmission dynamics in a hyperlocal region of Pune City in Western India.

Optimal Approach for TB Screening among HIV Infected Indian Children

Post Date:

2018-06-11

|

Countries:

|

Clinical Sites:

This study was terminated May 20, 2019. It was funded by the Fogarty International Center at the U.S. National Institutes of Health. Determining TB status (ie, uninfected, latent, and active TB disease) is more difficult among children, particularly HIV-infected children...

The Role of GeneXpert in Bacterial Diagnosis of Spinal Tuberculosis

Post Date:

2017-10-26

|

Countries:

|

Clinical Sites:

This study was teriminated June 19, 2019. It was funded by the Fogarty International Center at the U.S. National Institutes of Health. India has the maximum burden of tuberculosis (TB) in the world. In 2014, there were an estimated 9.6 million incident...

Lipid Mediators of Inflammation in TB and TB-Diabetes

Post Date:

2017-10-02

|

Countries:

|

Clinical Sites:

This study was terminated August 1, 2019. It was funded and conducted under the U.S. National Institutes of Health and is nested within Impact of Diabetes on TB Treatment Outcomes. Dr. Jonathan Golub was the PI. Studies have shown that individuals with...

Characteristics Associated with Mobile Phone Usage among TB Populations in Pune, India

Post Date:

2017-10-02

|

Countries:

|

Clinical Sites:

With 8.6 million people affected worldwide in 2012, the control and prevention of tuberculosis (TB) has become an international priority. In order to reduce burdens and achieve global goals for TB control, new and innovative tools are necessary. With a growing number of mobile phone subscriptions...

Risk Factors for Unfavourable Treatment Outcomes among Multidrug-Resistant Tuberculosis Patients in Public Sector Treatment in Pune

Post Date:

2017-03-29

|

Countries:

This study is funded and conducted under the U.S. National Institutes of Health, Fogarty International Center. This study seeks to identify risk factors associated with unfavourable treatment outcomes (death, treatment failure, default, XDR-TB) among multidrug-resistant...

Impact of HIV and Diabetes Mellitus on TB Drug Resistance and Recurrence

Post Date:

2017-03-02

|

Countries:

|

Clinical Sites:

This study was terminated in January 2021. Tuberculosis (TB) is the leading cause of mortality globally. With increasing burden of HIV and diabetes mellitus (DM), there is a critical need to understand the microbial response and ensuing disease dynamics of TB in the HIV-infected and diabetic host...

Cost-effectiveness of Xpert MTB/RIF for Diagnosing Pulmonary Tuberculosis in HIV-positive Patients

Post Date:

2016-12-01

|

Countries:

|

Clinical Sites:

This study was terminated October 8, 2019. This is a prospective cross-sectional study which will be conducted at BJGMC in Pune, India. The aim of this study is to see whether Xpert MTB/RIF is useful for early detection of pulmonary tuberculosis, and therefore cost-effective, as compared with...

Barriers to Early Treatment Initiation in Childhood Tuberculosis in High Incidence Setting

Post Date:

2016-04-21

|

Countries:

|

Clinical Sites:

This study was terminated October 25, 2019. Funded by the Fogarty International Center and led by PI Dr. Chhaya Tukaram Valvi, the aim of this study is to evaluate the time to treatment initiation and barriers to early treatment initiation in childhood tuberculosis. TB...

Barriers to Implementation of Isoniazid Preventive Treatment (IPT) in Pediatric Contacts of Sputum Positive Adults with Tuberculosis

Post Date:

2016-03-24

|

Countries:

|

Clinical Sites:

This study was terminated January 3, 2019. It was funded by the Fogarty International Center at the U.S. National Institutes of Health. Young children infected with M.tuberculosis can rapidly progress to pulmonary and extrapulmonary disease with high rates of mortality and...

Tuberculosis Noon Conference

Post Date:

2013-10-24

|

Countries:

|

Clinical Sites:

Hinduja Hospital

This effort ended in 2015. As part of the BJGMC-Johns Hopkins India Fogarty Training Program, from 2013-2015 CCGHE hosted the live Tuberculosis Noon Conference webcast. Led by Drs. Maunank Shah, Jonathan Golub, and Richard Chaisson, these webcast meetings brought together Johns Hopkins TB...

Pages

Impact of undernutrition on tuberculosis treatment outcomes in India: A multicenter prospective cohort analysis by Dr. Pranay Sinha

Post Date:

2023-04-17

|

Countries:

|

Clinical Sites:

Publication:

Clinical Infectious Diseases

Abstract Background Undernutrition is the leading risk factor for tuberculosis (TB) globally. Its impact on treatment outcomes is poorly defined. Methods We conducted a prospective cohort analysis of adults with drug-sensitive pulmonary TB at 5 sites from 2015–2019. Using multivariable Poisson...

Sex Differences in TB Clinical Presentation, Drug Exposure, and Treatment Outcomes in India

Post Date:

2023-04-01

|

Countries:

Publication:

CHEST

Background: The role of sex differences in clinical presentation, TB drug pharmacokinetic variables, and treatment outcomes is unclear. Research question: What is the effect of sex on TB disease severity, drug exposure, and treatment outcome? Study design and methods: This study was a prospective...

Characterising cause of death among people treated for drug-susceptible TB in India

Post Date:

2023-01-12

|

Countries:

Publication:

The International Journal of Tuberculosis and Lung Disease

Annually, 1.5 million people die of TB.1 India has thehighest burden of TB,1 and in 2020, the case fatality ratio (CFR) among people with drug-susceptible TB was 4.3%.2 Even after treatment, mortality is more than two-fold higher among people with prior TB compared to the general population.3...

Whole Genome Sequencing Assessing Impact of Diabetes Mellitus on Tuberculosis Mutations and Type of Recurrence in India

Post Date:

2022-10-06

|

Countries:

Publication:

Clinical Infectious Diseases

Dr. Vidya Mave and colleagues concluded considerable intrahost mycobacterium tuberculosis mutation rates were present at recurrence among patients with diabetes mellitus.

Concomitant pulmonary disease is common among patients with extrapulmonary TB

Post Date:

2022-08-12

|

Countries:

|

Clinical Sites:

Publication:

International Journal of Tuberculosis and Lung Disease

Dr. Shivakumar and his group discovered that a high proportion of patients classified as EPTB in India have concomitant PTB. Their results support the need for improved symptom and CXR screening, and recommends routine sputum TB microbiology screening of all Indian patients with EPTB.

Tuberculosis Pathways to Care and Transmission of Multidrug Resistance in India

Post Date:

2022-01-15

|

Countries:

Publication:

American Journal of Respiratory Critical Care Medicine

Abstract Rationale: India is experiencing a regional increase in cases of multidrug-resistant tuberculosis (MDR-TB). Objectives: Given the complexity of MDR-TB diagnosis and care, we sought to address key knowledge gaps in MDR risk factors, care delays, and drivers of delay to help guide disease...

Host lipidome and tuberculosis treatment failure

Post Date:

2022-01-06

|

Countries:

Publication:

European Respiratory Journal

Introduction: Host lipids play important roles in tuberculosis (TB) pathogenesis. Whether host lipids at TB treatment initiation (baseline) affect subsequent treatment outcomes has not been well characterised. We used unbiased lipidomics to study the prospective association of host lipids with TB...

Baseline IL-6 is a biomarker for unfavorable tuberculosis treatment outcomes: a multi-site discovery and validation study

Post Date:

2021-11-08

Publication:

The European Respiratory Journal

Dr. Akshay Gupte and colleagues discovered that elevated IL-6 can predict poor treatment outcomes, showcasing a need for including IL-6 in clinical screenings.

Tuberculosis Pathways to Care and Transmission of Multidrug-Resistance in India

Post Date:

2021-11-01

|

Countries:

Publication:

American Journal of Respiratory and Critical Care Medicine

Rationale: India is experiencing a regional increase in cases of multidrug-resistant tuberculosis (MDR-TB). Given the complexity of MDR-TB diagnosis and care, we sought to address key knowledge gaps in MDR risk factors, care delays, and drivers of delay to help guide disease control. Methods: From...

Modern lineages of Mycobacterium tuberculosis were recently introduced in western India and demonstrate increased transmissibility

Post Date:

2021-08-21

|

Countries:

Publication:

Open Forum Infectious Diseases

Background Mycobacterium tuberculosis (Mtb) transmissibility may vary between lineages (or variants) and this may contribute to the slow decline of tuberculosis (TB) incidence. The objective of our study was to compare transmissibility across four major lineages (L1-4) of Mtb among participants...

Diabetes Mellitus and Tuberculosis Treatment Outcomes in Pune, India

Post Date:

2021-04-01

|

Countries:

|

Clinical Sites:

Publication:

Open Forum Infectious Diseases

Background Diabetes mellitus (DM) increases the risk of tuberculosis (TB) disease. Knowledge of the impact of DM on TB treatment outcomes is primarily based on retrospective studies. Methods We conducted a prospective cohort study of new pulmonary TB patients with and without DM (TB-DM and TB only...

Unhealthy alcohol use independently associated with unfavorable TB treatment outcomes among Indian men

Post Date:

2021-03-10

|

Countries:

|

Clinical Sites:

Publication:

International Journal of Tuberculosis and Lung Disease

This study by Samyra Cox and colleagues highlights the need for integrating effective alcohol interventions into TB care.

Measuring TB drug levels in the hair in adults and children to monitor drug exposure and outcomes

Post Date:

2021-01-01

|

Countries:

Publication:

International Journal of Tuberculosis and Lung Disease

INTRODUCTION: Testing for anti-TB drugs in small hair samples may serve as a non-invasive tool to measure cumulative drug exposure and/or adherence, as these determine treatment success. We aimed to assess how well hair assays of TB drugs predict TB treatment outcomes.METHODS: A small thatch of...

The Impact of Hypertension and Use of Calcium Channel Blockers on Tuberculosis Treatment Outcomes

Post Date:

2020-09-24

|

Countries:

Publication:

Clinical Infectious Diseases

Background: Hypertension induces systemic inflammation, but its impact on the outcome of infectious diseases like tuberculosis (TB) is unknown. Calcium channel blockers (CCB) improve TB treatment outcomes in pre-clinical models, but their effect in patients with TB remain unclear. Methods: This...

Assessment of the Xpert assay among new pulmonary tuberculosis suspects with and without diabetes mellitus

Post Date:

2020-01-01

|

Clinical Sites:

Publication:

International Journal of Tuberculosis and Lung Disease

IJTLD: Deshmukh and colleagues: High sensitivity and specificity of Xpert underscores need for rapid scale up for early detection of TB in settings with a high dual burden of TB and DM

Lipid mediators of inflammation and resolution in individuals with tuberculosis and tuberculosis-diabetes

Post Date:

2019-11-11

Publication:

Prostaglandins and Other Lipid Mediators

Individuals with concurrent tuberculosis (TB) and Type 2 diabetes (DM) have a higher risk of adverse outcomes. To better understand potential immunological differences, we utilized a comprehensive panel to characterize pro-inflammatory and pro-resolving (i.e., mediators involved in the resolution...

Incidence of tuberculosis in HIV-infected adults on first- and second-line antiretroviral therapy in India

Post Date:

2019-10-29

|

Countries:

|

Clinical Sites:

Publication:

BMC Infectious Diseases

In this study among people living with HIV, Akshay Gupte and colleagues found that the risk of acquiring tuberculosis was higher in those receiving first-line antiretrovial therapy versus those receiving second-line medications.

Delays and barriers to early treatment initiation for childhood tuberculosis in India

Post Date:

2019-10-01

Publication:

International Journal of Tuberculosis and Lung Disease

BACKGROUND: India accounts for 27% of global childhood tuberculosis (TB) burden. Understanding barriers to early diagnosis and treatment in children may improve care and outcomes. METHODS: A cross-sectional study was performed among 89 children initiated on anti-TB treatment from a public hospital...

Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored

Post Date:

2019-07-31

|

Countries:

|

Clinical Sites:

Publication:

PLoS One

BACKGROUND: More than 20% of tuberculosis (TB) disease worldwide may be attributable to smoking and alcohol abuse. India is the second largest consumer of tobacco products, a major consumer of alcohol particularly among males, and has the highest burden of TB globally. The impact of...

Infection free "resisters" among household contacts of adult pulmonary tuberculosis

Post Date:

2019-07-18

|

Countries:

|

Clinical Sites:

Publication:

PLoS One

Despite substantial exposure to infectious pulmonary tuberculosis (TB) cases, some household contacts (HHC) never acquire latent TB infection (LTBI). Characterizing these "resisters" can inform who to study immunologically for the development of TB vaccines. We enrolled HHCs of culture-confirmed...

Pages

Yasmin Ogale

Yasmin Ogale received her MPH from Bloomberg School of Public Health in 2015. From September to December 2014, she conducted a field study in Pune, India, under the guidance of Dr. Jonathan Golub, on indoor air pollution and tuberculosis. Ms. Ogale is a 2014 recipent of the Global Health Established Field Placement Grant.

Jessica Elf, MPH, PhD

Post Doctoral Fellow

Dr. Jessica Elf was a post doctoral fellow in the Department of International Health at the Johns Hopkins School of Public Health. Her primary research focus was on the epidemiology and health impacts of tobacco use and exposure to indoor air pollution from the combustion of biomass fuels. She is a former Fogarty Fellow who lived and worked in Pune, India conducting research for her thesis project, which investigated the association between indoor air pollution and tuberculosis. She completed her undergraduate education in nutrition at the University of Florida and received an MPH and...

Akshay Gupte, PhD, MBBS, MSPH, PhD

Assistant Professor

Dr. Gupte is Assistant Professor of Global Health at the Boston University School of Public Health. His research is focused on the intersection of infectious and chronic lung diseases in low- and middle-income settings. He is the PI/multi-PI of NIH funded Indo-US collaborative studies to describe the epidemiology and pathogenesis of lung impairment in tuberculosis (TB)/HIV/diabetes, measure its impact on poor clinical outcomes, and identify therapeutic and programmatic interventions to improve post-TB lung health and longevity. Dr. Gupte serves on several multi-national TB/HIV research...

New study aims for best strategy to find recurrent cases of Tuberculosis

Post Date:

2023-09-15

Source:

Indian Express

A novel trial is underway in Pune to provide evidence on how best to find people with recurrent Tuberculosis (TB) , so that they can be quickly linked to care.