Jyoti Mathad, MD, MSc

Role: 
Faculty
Assistant Professor, Weill Cornell Medical College

Dr. Mathad is an Assistant Professor of Medicine and Obstetrics & Gynecology in the the Center for Global Health at Weill Cornell Medical College. She is also a faculty member at the Johns Hopkins Center for Clinical Global Health Education.

Her primary research interests include the immune and metabolic changes of pregnancy and their impact on the pathogenesis of infectious diseases such as tuberculosis (TB). She has been conducting NIH-funded research in Pune, India, since 2010 when she studied the performance of immune-based latent TB diagnostics in pregnant women with and without HIV. She then led the PRACHITi study (NICHD R01HD081929) there, which investigated the impact of stage of pregnancy and HIV on the immune response to M. tuberculosis. She received an NIH K23 to compare the host immune response to M. tuberculosis in pregnant and non-pregnant women in India. She also received an NIH R21 to examine how maternal HIV, even when controlled, impacts the placenta and programming of the fetal immune system. Most recently she has received funding to investigate the association of HIV with gestational diabetes, and gestational diabetes with the immune response to M. tuberculosis (NIAID R01AI162235). An active member of the International Maternal, Pediatric, and Adolescent AIDS Clinical Trials network (IMPAACT), Dr. Mathad chaired the only study of the safety, tolerability and pharmacokinetics of the 3-month isoniazid/rifapentine regimen for latent TB treatment in pregnant and postpartum women (IMPAACT 2001). She will now be leading the DOLPHIN-Moms study, which will study the safety of 3HP versus 1-month of daily isoniazid and rifapentine (1HP) for TB prevention in pregnant women living with HIV. 

In addition to her innovative research, Dr. Mathad also devotes considerable time to mentoring students, residents, and fellows interested in global health, both in New York and India. She has a particular interest in developing the careers of female trainees and co-leads the Women in Global Health Research Initiative at Weill Cornell.

Prevalence of gestational diabetes (GDM) and postpartum diabetes (DM) and their risk factors at Sassoon General Hospital and Byramjee Jeejeebhoy Government Medical College in Pune, India

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2021-12-19
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Primary objective: To determine the prevalence of GDM in a population of women in our hospital To identify the risk factors for GDM and determine the prevalence of GDM risk factors in a population of women screened for GDM and their association with GDM To determine the incidence and time course of...

Pregnancy Associated Immune Responses to Tuberculosis and HIV in India and South Africa (PARTHISA)

Post Date: 
2020-01-14
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Dr. Jyoti Mathad is Co-PI of this study. Purpose: Tuberculosis (TB) is a leading cause of maternal mortality, especially among HIV-infected women. Women are most likely to develop active TB during and immediately after pregnancy. The immunologic conditions responsible for this phenomenon are not...

Immune Correlates of LTBI in HIV-exposed Infants

Post Date: 
2019-04-29
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About 2 billion people worldwide harbor asymptomatic latent TB infection (LTBI), activation of which results in progression to TB disease. In areas of high tuberculosis (TB) prevalence, infants and young children have a 3-fold higher risk of progression and death from TB at age < 5 years...

Vaginal Microbiota in HIV Infected and Uninfected Pregnant Women (Stand Alone)

Post Date: 
2018-10-16
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Amita Gupta, MD, MHS, and Shilpa Naik, MD, are PIs for this study; Rupak Shivakoti, PhD, MSPH, is Co-Investigator The makeup of vaginal microbiota is dynamic and may play a role in the birth outcomes of pregnant women. While HIV and pregnancy both uniquely impact vaginal microbiota, the impact of...

Gut Microbiota of HIV Infected Pregnant Women

Post Date: 
2018-06-14
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Birth Outcomes in HIV Both antiretroviral-therapy (ART)-naïve and ART-experienced HIV-infected pregnant women have higher incidences of pre-term birth (PTB) compared to HIV-uninfected women. For example, the global prevalence of PTB is around 8%, while the rates in in HIV-infected...

Zika Surveillance among Antenatal Clinic Outpatients in BJ Government Medical College and Sassoon General Hospitals, Pune, India

Post Date: 
2017-08-31
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This study was terminated July 21, 2020. Zika virus is a vector-borne disease carried by the mosquito Aedes aegypti . Pregnant women infected with Zika may pass the virus to the fetus, which may cause microcephaly and other severe brain defects. It is also linked to...

Investigating Maternal Antibodies to Modify Infant Tuberculosis Acquisition

Post Date: 
2017-08-29
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New study in Pune, India, aims to identify the profile of TB antibodies between mothers and infants, and to see if the presence of antibodies lowers risk of infant infection.

Vaginal Microbiota in HIV Infected Pregnant Women

Post Date: 
2017-07-14
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This study is conducted under CCGHE’s PRACHITI (PRegnancy And CHanges In TuberculosIs) effort, supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the U.S. National Institutes of Health. Led by Dr. Rupak Shivakoti, this is a...

Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome and Preterm Birth

Post Date: 
2014-10-28
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This study was terminated May 7, 2018. P regnancy is a state of relative immunosuppression in order to protect the fetus from being rejected. It has also been shown that the Th-1 helper cell response, which is normally necessary for overcoming TB infection...

Predictive Value of TB-symptom Screen in HIV-infected and HIV-uninfected Pregnant Women in Pune, India

Post Date: 
2014-10-28
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This study was terminated July 17, 2017. This is a cross sectional observational study will be conducted at BJGMC to establish what the predictive value of the WHO TB symptom screen is in pregnant women in India. We hypothesize that the WHO TB symptom...

Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis

Post Date: 
2014-09-01
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This is the Parent Study for CCGHE’s PRACHITI (PRegnancy And CHanges In TuberculosIs) effort. It's supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the U.S. National Institutes of Health. Purpose: TB is a...

Diagnosis of Tuberculosis Infection and Th1 Immune Response in Pregnant Women in India

Post Date: 
2014-09-01
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This study was terminated April 16, 2018. Tuberculosis (TB) disease is a major cause of mortality among Indian women of reproductive age; approximately 20-50% of women in India are latently infected with Mycobacterium tuberculosis (MTB). Due to immune...

P1078: A Phase IV Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Safety of Immediate (Antepartum-Initiated) Versus Deferred (Postpartum-Initiated) Isoniazid Preventive Therapy Among HIV-Infected Women in High TB Incidence Settings

Post Date: 
2014-04-01
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This is a clinical trial conducted under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health. Dr. Amita Gupta is Protocol Chair for this multinational clinical trial being conducted in...

Epidemiological Assessment of Pediatric Tuberculosis in Pune, India, through Contact Tracing

Post Date: 
2013-06-10
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This study ended in June 2016. Approximately 1 million new cases of Tuberculosis occur among children each year around the world, with a large number of these cases occurring among indigent populations without access to adequate healthcare facilities (World Health Organization). Due to their high...

Impact of Malnutrition on HIV Treatment Failure in Resource-limited Settings

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2009-04-02
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This study, NWCS 319, was terminated August 20, 2019. Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality among HIV-infected persons worldwide. However, early treatment failure (i.e. WHO stage 3 or 4 illnesses or death...

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

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2007-02-02
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Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

Pharmacokinetics and Safety of 3 Months of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention in Pregnant Women

Post Date: 
2022-06-01
Publication: 
Clinical Infectious Diseases
Background Pregnancy increases the risk of tuberculosis and its complications. A 3-month regimen of weekly isoniazid and rifapentine (3HP) is safe and effective for tuberculosis prevention in adults and children, including those with HIV, but 3HP has not been evaluated in pregnancy. Methods IMPAACT...

Validation of New Interactive Nutrition Assistant - Diet in India Study of Health (NINA-DISH) FFQ with multiple 24-h dietary recalls among pregnant women in Pune, India

Post Date: 
2021-11-02
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The British Journal of Nutrition
Adequate dietary intake is critical to prevent adverse pregnancy outcomes. India has a high burden of maternal and child morbidity and mortality, but there is a lack of adequate tools to assess dietary intake. We validate an FFQ, New Interactive Nutrition Assistant - Diet in India Study of Health (NINA-DISH), among pregnant women living with and without HIV in Pune, India.

Systemic Inflammation in Pregnant Women With Latent Tuberculosis Infection

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2021-01-27
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Frontiers in Immunology
Background: Recent studies in adults have characterized differences in systemic inflammation between adults with and without latent tuberculosis infection (LTBI+ vs. LTBI-). Potential differences in systemic inflammation by LTBI status has not been assess in pregnant women. Methods: We conducted a...

Validation of NINA-DISH food frequency questionnaire with multiple 24-hour dietary recalls among pregnant women in Pune, India

Post Date: 
2021-01-06
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The British Journal of Nutrition
Adequate dietary intake is critical to prevent adverse pregnancy outcomes. India has a high burden of maternal and child morbidity and mortality, but there is a lack of adequate tools to assess dietary intake. We validate a food frequency questionnaire (FFQ), New-Interactive Nutrition Assistant-...

Association of Vegetable and Animal Flesh Intake with Inflammation in Pregnant Women from India

Post Date: 
2020-12-08
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MDPI
In pregnant women, studies are lacking on the relationship of vegetable and animal flesh (poultry, red meat and seafood) intake with inflammation...

Effects of Pregnancy and Isoniazid Preventive Therapy on M. tuberculosis Interferon Gamma Response Assays in Women with HIV

Post Date: 
2020-07-28
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Clinical Infectious Diseases
944 women with HIV participating in a randomized, double-blind, placebo-controlled study comparing 28 weeks of IPT antepartum versus postpartum, were tested by QuantiFERON-gold-in-tube (QGIT) antepartum and by QGIT and tuberculin skin test (TST) at delivery and postpartum.

Trends and gender differences in access to HIV care with scale up of national HIV treatment guidelines in India

Post Date: 
2020-06-24
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Journal of the International Association of Providers of AIDS Care
Test and treat is the current global standard, yet sex differences persist in access to HIV care. We assessed the differences in presentation and antiretroviral therapy (ART) uptake by sex and ART-eligibility period among ART-naive adults registered at a public ART center in India. Four ART...

Intensified short symptom screening program for Dengue infection during pregnancy, India

Post Date: 
2020-04-15
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Emerging Infectious Diseases
Mosquitoborne diseases (e.g., malaria, dengue, and chikungunya) are endemic to India and pose diagnostic challenges during pregnancy. We evaluated an intensified short symptom screening program in India to diagnose dengue during pregnancy. During October 2017-January 2018, we screened pregnant...

TB prevention strategies and unanswered questions for pregnant and postpartum women living with HIV: the need for improved evidence

Post Date: 
2020-03-23
Publication: 
Journal of the International AIDS Society
World TB Day viewpoint on the need for more data about TB treatment for pregnant and postpartum women in J Int AIDS Soc by Drs. Jyoti Mathad and Amita Gupta.

Mobile phone access and comfort: implications for HIV and tuberculosis care in India and South Africa.

Post Date: 
2019-07-01
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International Journal of Tuberculosis and Lung Disease
SETTING: India and South Africa shoulder the greatest burden of tuberculosis (TB) and human immunodeficiency virus (HIV) infection respectively, but care retention is suboptimal. OBJECTIVE: We conducted a study in Pune, India, and Matlosana, South Africa ...

Female global health leadership: Data-driven approaches to close the gender gap

Post Date: 
2019-02-09
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The Lancet
Lancet article investigates gender-based challenges of female health trainees and professionals and identifies interventions

Symptom screening for active tuberculosis in pregnant women living with HIV

Post Date: 
2019-01-24
Publication: 
Cochrane Database of Systematic Reviews
This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows: To assess the accuracy of the four-symptom screen (cough, fever, night sweats, or weight loss) for identifying active TB in pregnant PLHIV who are screened in an outpatient or community setting...

Is there a connection between gestational diabetes, human immunodeficiency virus infection, and tuberculosis?

Post Date: 
2019-01-01
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International Journal of Tuberculosis and Lung Disease
IJTLD article reviews the epidemiology and immunology of gestational diabetes and finds there's a lot we don't know about interactions between diabetes, pregnancy, and tuberculosis in both HIV+/- women

Re: How serious are global health leaders about gender equality?

Post Date: 
2018-04-06
Publication: 
British Medical Journal
Letter to the Editor: At the 2017 Consortium of Universities for Global Health (CUGH) in Washington, D.C., a panel of female global health leaders (AG, MB, IK, JM, YM) discussed the barriers to female leadership and put forward actionable advice on how to address them.

Screening and diagnosis of gestational diabetes in India: A systematic review and meta analysis

Post Date: 
2018-03-26
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Acta Diabetologica
Review article on prevalence and screening and diagnostic methods for gestational diabetes in India.

Household food insecurity is associated with low interferon-gamma levels in pregnant Indian women

Post Date: 
2017-07-01
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Publication: 
International Journal of Tuberculosis and Lung Disease
Objective: To determine the association between household food insecurity and interferon-gamma (IFN-γ) levels in pregnancy. Design: Pregnant women in India were administered the Household Food Insecurity Access Scale (HFIAS) questionnaire and underwent an IFN-γ release assay...

Pulmonary infections in pregnancy

Post Date: 
2017-06-01
Publication: 
Seminars in Respiratory and Critical Care Medicine
Clinical review from Drs. Amita Gupta & Jyoti Mathad on improving tuberculosis treatment outcomes for pregnant women.

The ripple effect: why promoting female leadership in global health matters

Post Date: 
2016-12-21
Publication: 
Public Health Action
Leadership positions in global health are greatly skewed toward men; the imbalance is more pronounced in low- and middle-income countries (LMICs). The under-representation of women in leadership is a threat to gender equality, and also impacts the improvement of women's health outcomes...

Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation

Post Date: 
2016-10-01
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Publication: 
Journal of Acquired Immune Deficiency Syndromes
Background: Women progress to death at the same rate as men despite lower plasma HIV RNA (viral load). We investigated sex-specific differences in immune activation and inflammation as a potential explanation. Methods: Inflammatory and immune activation markers [...

Quantitative IFN-y,IL-2 response and latent tuberculosis test discordance in HIV-infected pregnant women

Post Date: 
2016-06-15
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American Journal of Respiratory and Critical Care Medicine
Rationale: Pregnant women with latent tuberculosis infection (LTBI) are at high risk for development of TB, especially if infected with HIV. Objectives: To assess the performance of LTBI tests in pregnant and postpartum women infected with HIV, investigate the...

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Puja Chebrolu

Global Health Research Fellow
Puja Chebrolu
Dr. Chebrolu is an Internal Medicine physician and a Cornell Global Health Research Fellow. She is working with Dr Jyoti Mathad and Dr Mallika Alexander at BJGMC primarily to study gestational diabetes within the PRACHITI cohort. She will be working with BJMC over the next 3 years and plans to study diabetes in other study populations as well.

Rifapentine demonstrates efficacy for pregnant women, including those with HIV

Post Date: 
2020-03-14
Source: 
Infectious Disease News via Healio
Dr. Jyoti Mathad
Infectious Disease News via Healio: Jyoti Mathad discusses findings from the IMPAACT 2001 clinical trial.

We Are Weill Cornell Medicine: Dr. Jyoti Mathad

Post Date: 
2018-05-18
Video by Weill Cornell Medicine features Jyoti Mathad and her work with the Indo-JHU Clinical Research Partnership.

How can we encourage female leaders in global health?

Post Date: 
2017-08-09
Source: 
Global Health Matters
Fogarty Director Dr. Roger Glass asks why so few women are leading global health centers at med schools or filling other leadership roles.

Amita Gupta and colleagues discuss female leadership in academic global health

Post Date: 
2017-05-04
Drs. Gupta, Manabe, Mathad discuss need for more women in global health leadership at CUGH's annual meeting.

Tuberculosis test may underreport in pregnant women with HIV

Post Date: 
2016-01-28
Source: 
Infectious Disease Advisor
Pregnancy may confound tuberculosis (TB) tests results in women with HIV, according to research published in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine .

Tuberculosis scare in HIV positive pregnant women: most widely-used tuberculosis test fails to diagnose illness

Post Date: 
2016-01-28
Source: 
International Business Times
The most commonly-used tuberculosis (TB) test, TST, has failed to detect TB in HIV positive pregnant women. A research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine has revealed that the TB test failed to accurately diagnose the...

Awards and honors across Weill Cornell – Week of March 25-April 3

Post Date: 
2015-04-03
Source: 
Weill Cornell Newsroom
Dr. Jyoti Mathad, an instructor in medicine, was named an Ujala Foundation Scholar by the Center for Clinical Global Health Education at Johns Hopkins Medicine. Dr. Mathad is one of eight scholars who will work to improve healthcare in India, with a particular focus on fighting tuberculosis...