Neetal Nevrekar, MBBS

Pune, India
Role: 
Staff
Research Clinician
Neetal Nevrekar, MBBS

Dr. Neetal Nevrekar is a Clinical Coordinator at the John Hopkins Center for Infectious Diseases in India (CIDI) and the Byramjee Jeejeebhoy Government Medical College Clinical Research Site (BJGMC-CRS), based in Pune, India.  She is a gynecologist by training with over 20 years of clinical experience. Her research interests are women’s health, pregnant and postpartum women living with HIV, and treatment and prevention of HIV-TB co-infection. Dr. Nevrekar joined the BJGMC-JHU CRS in June 2010 and is currently the clinical coordinator in the NIH-funded ACTG and IMPAACT network clinical trials which include a large multicenter MDR-TB preventive study- A5300B/I2003/PHOENIx, A5362-CLO-FAST study- DS-TB treatment shortening trial, and IMPAACT 2026, a Pharmacokinetic study for ART and Anti-TB drugs in pregnant and postpartum women living with HIV.

In her present role, she coordinates the clinical and study-related activities for these studies at the site. These activities involve developing the source documents for research protocols, screening and enrolling the research participants, completing clinical record forms, ensuring that the study procedures are conducted in accordance with the study protocol and as per the SOP and HSP-GCP guidelines, training research staff and CAB members, reporting to the regulatory bodies at the site. She is also responsible for communicating with the Clinical Managing Committee (CMC) of respective studies, CRS leadership, study laboratories, and BJGMC faculty regarding the clinical issues and expedited adverse event reporting to RSC/DAIDS. She has worked in different capacities including as Research Officer and Study Clinician on the network research protocols including A5207, A5253, A5225, 1077BF, and 1077FF (PROMISE), A5274, A5282, A5288, A5302, and P1078. She has also conducted the ACTG-TBTC collaborative A5349/ S31 study of treatment shortening for drug-sensitive (DS)-TB at the BJGMC site.

She received an undergraduate degree from Grant Medical Institute, Mumbai, and a Doctor of Medicine in Obstetrics and Gynecology from Grant Medical Institute and Bombay Hospital Research Centre. She has also obtained the Diplomat of National Board (DNB) degree from New Delhi. She worked as a senior medical officer at Bombay Hospital-Medical Research Centre for four years. Subsequently, she was a consultant in Obstetrics and Gynecology at various private hospitals for six years before joining the CRS.

She has served as a member of the Women’s Health Inter-Network Scientific Committee (WHISC) for the IMPAACT and ACTG Network 2012- 2014. Presently, she is a member of the Women’s Health Collaborative Science Group (WHCSG) at the ACTG Network. She has attended the annual IMPAACT network meetings in Washington, DC, in 2011, 2017, and 2019. She has also attended the Women in Global Health Research Symposium at Weil Cornell Center for Global Health in 2016.

Dr. Nevrekar was selected for the Partnerships for Enhanced Education in Research (PEER) Women in Science Mentorship Program under the mentorship of Dr. Nishi Suryavanshi. She has completed the one-year PEER Mentorship Program which was supported by the United States Agency for International Development (USAID) and implemented by the U.S. National Academies of Sciences, Engineering, and Medicine in 2021. As a part of the program, she submitted a pilot project on understanding the barriers and facilitators in the tuberculosis prevention care cascade for optimizing isoniazid preventive therapy uptake among adults living with HIV in India and applied for the seed grant funding. The research project was reviewed, selected, and funded by the USAID.

“Bridging the Gaps”: Understanding the Barriers and Facilitators in the Tuberculosis Prevention Care Cascade for Optimizing Isoniazid Preventive Therapy Uptake among Adults Living with HIV in India, a Mixed-Method Approach

Post Date: 
2021-11-02
   |   
Countries: 
   |   
Clinical Sites: 
PURPOSE: The isoniazid preventive therapy policy has achieved limited success in low and middle-income countries. With limited empirical research exploring the barriers to suboptimal IPT uptake, it is important to understand this knowledge gap. Also, limited programmatic strategies exist to address...

A5362: A Phase IIc Trial of Clofazimine- and Rifapentine-Containing Treatment Shortening Regimens in Drug-Susceptible Tuberculosis: The CLO-FAST Study

Post Date: 
2021-06-15
   |   
Countries: 
   |   
Clinical Sites: 
Primary Hypothesis A 3-month regimen of rifapentine/isoniazid/pyrazinamide/ethambutol (PHZE) with clofazimine (CFZ) dosed as 100 mg daily with a 2-week 300 mg daily loading dose (Arm 1) will demonstrate early efficacy (time to 12-week liquid culture conversion) relative to standard of care (SOC) (...

P2026: Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs during Pregnancy and Postpartum

Post Date: 
2021-05-18
   |      |   
Clinical Sites: 
IMPAACT P1026s, the predecessor of this study, was first approved in 2003. P1026s enrolled over 1000 pregnant/postpartum women, studied the PK of more than 25 HIV and TB drugs in these women and published 27 manuscripts presenting these data. P1026s data was cited in 32% of the 76 perinatal...

Pregnancy Associated Immune Responses to Tuberculosis and HIV in India and South Africa (PARTHISA)

Post Date: 
2020-01-14
   |   
Countries: 
   |   
Clinical Sites: 
Dr. Jyoti Mathad is Co-PI of this study. Purpose: Tuberculosis (TB) is a leading cause of maternal mortality, especially among HIV-infected women. Women are most likely to develop active TB during and immediately after pregnancy. The immunologic conditions responsible for this phenomenon are not...

Gut Microbiota of HIV Infected Pregnant Women

Post Date: 
2018-06-14
   |   
Countries: 
   |   
Clinical Sites: 
Birth Outcomes in HIV Both antiretroviral-therapy (ART)-naïve and ART-experienced HIV-infected pregnant women have higher incidences of pre-term birth (PTB) compared to HIV-uninfected women. For example, the global prevalence of PTB is around 8%, while the rates in in HIV-infected...

Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis

Post Date: 
2014-09-01
   |   
Countries: 
   |   
Clinical Sites: 
This is the Parent Study for CCGHE’s PRACHITI (PRegnancy And CHanges In TuberculosIs) effort. It's supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the U.S. National Institutes of Health. Purpose: TB is a...

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date: 
2007-02-02
   |   
Countries: 
   |   
Clinical Sites: 
Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

A5207: Maintaining Options for Mothers Study (MOMS): A Phase II Randomized Comparison of Three Antiretroviral Strategies Administered for 7 or 21 Days to Reduce the Emergence of Nevirapine Resistant HIV-1 Following a Single Intrapartum Dose of Nevirapine

Post Date: 
2004-12-20
   |   
This study was terminated January 16, 2014; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. A major disadvantage of giving SD NVP is the potential for maternal development of NVP resistance and additional...

Operational challenges undermine the WHO TB symptom screen in pregnant women in India

Post Date: 
2023-04-26
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
Open Forum Infectious Diseases
Background. Pregnancy increases both a woman's risk of developing tuberculosis (TB) and her likelihood to seek health care. A symptom screen that is effective during pregnancy would therefore be valuable. We assessed a World Health Organization (WHO)-recommended TB symptom screen in an antenatal...

Self-Reported Antiretroviral Adherence: Association with Maternal Viral Load Suppression in Postpartum Women Living with HIV-1 from Promoting Maternal and Infant Survival Everywhere (PROMISE), a Randomized Controlled Trial in Sub-Saharan Africa and India

Post Date: 
2023-01-01
   |   
Countries: 
Publication: 
Journal of Acquired Immune Deficiency Syndrome
Introduction: Optimal adherence to antiretroviral therapy (ART) is crucial to promoting maternal–infant health. Setting: Fourteen sites in 7 countries within sub-Saharan Africa and India. Methods: The multicomponent, open-label strategy PROMISE trial enrolled breastfeeding mother–infant pairs not...

Virological Failure among People living with HIV Receiving Second-Line Antiretroviral Therapy in Pune, India

Post Date: 
2022-12-17
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
BMC Infectious Diseases
Background The number of people receiving second-line antiretroviral therapy (ART) has increased as global access to ART has expanded. Data on the burden and factors associated with second-line ART virologic failure (VF) from India remain limited. Methods We conducted cross-sectional viral load (VL...

Association of Vegetable and Animal Flesh Intake with Inflammation in Pregnant Women from India

Post Date: 
2020-12-08
   |   
Countries: 
Publication: 
MDPI
In pregnant women, studies are lacking on the relationship of vegetable and animal flesh (poultry, red meat and seafood) intake with inflammation...

Elevated highly sensitive C-reactive protein and d-dimer levels are associated with food insecurity among people living with HIV in Pune, India

Post Date: 
2019-03-04
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
Public Health Nutrition
Abstract OBJECTIVE: To assess the prevalence and determinants of food insecurity among people living with HIV (PLWH) in Pune, India and its association with biomarkers known to confer increased risks of morbidity and mortality in this population. DESIGN:...

High prevalence of cryptococcal antigenaemia amongst asymptomatic advanced HIV patients in Pune, India

Post Date: 
2017-03-21
   |   
Countries: 
   |   
Clinical Sites: 
Publication: 
Indian Journal of Medical Microbiology
Methods : A prospective study was conducted in a large public sector ART centre and the inpatient wards of Sassoon Hospital, Pune, India. All consenting patients> 18 years of age with CD4 count <100 cells/mm3 were screened for CrAg by latex agglutination assay. Those with positive CrAg...

Mentorship Award!

Post Date: 
2021-11-02
Gauri Dhumal and Neetal Nevrekar Receive PEER Grant Award
Gauri Dhumal and Neetal Nevrekar received the award from USAID’s Women in Science Mentoring Program for separate pilot projects that study better tuberculosis treatment methods. Nishi Suryavanshi is their mentor.

Uniting for a Healthier India

Post Date: 
2018-02-14
"The Indo-US clinical research & education partnership started with a single NIH grant to study maternal-infant HIV transmission." Now with 76 studies underway, this short film chronicles the history & impact of our work in India.