Inflammation

Inflammasome Genetics and Tuberculosis Treatment Outcomes

Post Date: 
2019-11-07
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
NIRT
Dr. Amita Gupta is a Co-PI on this study. STUDY DESIGN We will conduct a retrospective case-cohort study nested within the CTRIUMPH and EDOTS cohorts to address our study objectives. This will enable us to measure the association of polymorphisms with multiple clinical outcomes simultaneously and...

Gut Microbiota of HIV Infected Pregnant Women

Post Date: 
2018-06-14
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Birth Outcomes in HIV Both antiretroviral-therapy (ART)-naïve and ART-experienced HIV-infected pregnant women have higher incidences of pre-term birth (PTB) compared to HIV-uninfected women. For example, the global prevalence of PTB is around 8%, while the rates in in HIV-infected...

Lipid Mediators of Inflammation in TB and TB-Diabetes

Post Date: 
2017-10-02
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Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated August 1, 2019. It was funded and conducted under the U.S. National Institutes of Health and is nested within Impact of Diabetes on TB Treatment Outcomes. Dr. Jonathan Golub was the PI. Studies have shown that individuals with...

Association of Lipid Mediators of Inflammation with TB Treatment Outcomes

Post Date: 
2017-08-03
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Countries: 
India
   |   
Clinical Sites: 
BJGMC
NIRT
This study was terminated July 22, 2019. This study used stored samples from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB...

MDR-TB Free: Monitoring Adverse Effects, Utilizing Resources Optimally, Knowing Resistance Patterns, and Treatment Strategy

Post Date: 
2017-03-24
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Hinduja Hospital
This study is also known as MDR-TB MUKT: Monitoring Adverse Effects, Utilizing Resources Optimally, Knowing Resistance Patterns, and Treatment Strategy. Purpose: To establish an observational cohort of MDR-TB cases and household contacts with accompanying biorepository at PD Hinduja National...

Inflammation in HIV-infected Pregnant Women: Relationship with Diet, Gut Microbiome and Preterm Birth

Post Date: 
2014-10-28
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
NIRT
This study was terminated May 7, 2018. P regnancy is a state of relative immunosuppression in order to protect the fetus from being rejected. It has also been shown that the Th-1 helper cell response, which is normally necessary for overcoming TB infection...

ART Study 1: Database: Epidemiology of HIV/AIDS and Associated Comorbidities in a Public Antiretroviral Treatment (ART) Clinic at BJGMC in Pune

Post Date: 
2014-06-14
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Hinduja Hospital
Since 2004, the National AIDS Control Program of India has been rolling out free antiretroviral therapy. Byramjee Jeejeebhoy Government Medical College (BJGMC), located in Pune, India, is now the largest HIV clinic in India, with over 26,000 adult and pediatric patients registered since 2005...

Impact of Malnutrition on HIV Treatment Failure in Resource-limited Settings

Post Date: 
2009-04-02
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study, NWCS 319, was terminated August 20, 2019. Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality among HIV-infected persons worldwide. However, early treatment failure (i.e. WHO stage 3 or 4 illnesses or death...

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date: 
2007-02-02
   |   
Countries: 
India
United States
   |   
Clinical Sites: 
BJGMC
Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

BJGMC-JHU Fogarty HIV-TB Training Program

Post Date: 
2007-01-01
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Countries: 
India
   |   
Clinical Sites: 
BJGMC
Funded by the Fogarty International Center at the National Institutes of Health, the JHU Fogarty program has nearly 20 years of success with providing training, professional development, and mentorship to clinicians and scientists in low and middle income countries. CCGHE's latest efforts in...

A parsimonious host inflammatory biomarker signature predicts incident TB and mortality in advanced HIV

Post Date: 
2019-11-25
Publication: 
Clinical Infectious Diseases
BACKGROUND: People with advanced HIV (CD4<50) remain at high risk of TB or death despite the initiation of antiretroviral therapy. We aimed to identify immunological profiles that were most predictive of incident TB disease and death. METHODS: The REMEMBER randomized clinical trial enrolled 850...

Lipid mediators of inflammation and resolution in individuals with tuberculosis and tuberculosis-diabetes

Post Date: 
2019-11-11
Publication: 
Prostaglandins and Other Lipid Mediators
Individuals with concurrent tuberculosis (TB) and Type 2 diabetes (DM) have a higher risk of adverse outcomes. To better understand potential immunological differences, we utilized a comprehensive panel to characterize pro-inflammatory and pro-resolving (i.e., mediators involved in the resolution...

Inflammation and micronutrient biomarkers predict clinical HIV treatment failure and incident active TB in HIV-infected adults: a case-control study

Post Date: 
2018-09-24
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Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
BMC Medicine
Factors identified through exploratory factor analysis were associated with adverse outcomes in HIV-infected individuals.

Intestinal barrier dysfunction and microbial translocation in HIV-infected pregnant women is associated with preterm birth

Post Date: 
2018-03-24
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
NIRT
Publication: 
Clinical Infectious Diseases
Our results show select immune markers can identify women at higher risk for PTB in HIV-1-infected populations and suggest modulating gut barrier integrity and microbial translocation may affect PTB.

Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation

Post Date: 
2016-10-01
   |   
Countries: 
Brazil
Haiti
India
Malawi
Peru
South Africa
Thailand
United States
Zimbabwe
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Background: Women progress to death at the same rate as men despite lower plasma HIV RNA (viral load). We investigated sex-specific differences in immune activation and inflammation as a potential explanation. Methods: Inflammatory and immune activation markers [...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

Post Date: 
2016-07-01
   |   
Countries: 
India
Publication: 
Journal of Infectious Diseases
Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the...

Inflammation and change in body weight with antiretroviral therapy initiation in a multinational cohort of HIV-infected adults

Post Date: 
2016-04-01
   |   
Countries: 
Brazil
Haiti
India
Malawi
Peru
South Africa
Thailand
United States
Zimbabwe
   |   
Clinical Sites: 
BJGMC
Publication: 
The Journal of Infectious Diseases
Background: Both wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation during human immunodeficiency virus infection is unknown. Methods: Among a random virologically suppressed participants of the...

Persistently elevated C-reactive protein level in the first year of antiretroviral therapy, despite virologic suppression, is associated with HIV disease progression in resource-constrained settings

Post Date: 
2016-04-01
   |   
Countries: 
Brazil
Haiti
India
Malawi
Peru
South Africa
Thailand
United States
Zimbabwe
   |   
Clinical Sites: 
BJGMC
Publication: 
The Journal of Infectious Diseases
A case-cohort analysis of human immunodeficiency virus (HIV)-infected individuals receiving antiretroviral therapy (ART) was performed within a multicountry randomized trial (PEARLS) to assess the prevalence of persistently elevated C-reactive protein (CRP) levels, based on serial...

Concurrent anemia and elevated CRP predicts HIV clinical treatment failure, including TB, post-antiretroviral therapy initiation

Post Date: 
2015-07-01
   |   
Countries: 
Brazil
Haiti
India
Malawi
Peru
South Africa
Thailand
United States
Zimbabwe
   |   
Clinical Sites: 
BJGMC
Publication: 
Clinical Infectious Diseases
Background: Anemia is a known risk factor for clinical failure following antiretroviral therapy (ART). Notably, anemia and inflammation are interrelated, and recent studies have associated elevated C-reactive protein (CRP), an inflammation marker, with adverse human immunodeficiency virus (...

C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings

Post Date: 
2015-02-26
   |   
Countries: 
Brazil
Haiti
India
Malawi
Peru
South Africa
Thailand
United States
Zimbabwe
Publication: 
PLOS One
Objective: The association between pre-antiretroviral (ART) inflammation and immune activation and risk for incident tuberculosis (TB) after ART initiation among adults is uncertain. Design: Nested case-control study (n = 332) within ACTG PEARLS trial of...