Publications - Tuberculosis

Patterns of TB drug-resistance in a tertiary care facility in Pune, India

Post Date: 
2013-07-18
   |   
Countries: 
India
Publication: 
Clinical Microbiology
Introduction:Globally, the emergence of multi-drug resistant tuberculosis (MDRTB) (defined as resistance to isoniazid (INH) and rifampicin (RIF) and extensively drug resistant (XDR-TB) (defined as resistance to INH, RIF, any fluoroquinolone and to at least one of the three injectable second...

Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253

Post Date: 
2013-04-15
   |   
Countries: 
Botswana
Brazil
India
Malawi
Peru
South Africa
Zimbabwe
   |   
Clinical Sites: 
BJGMC
Publication: 
International Journal of Tuberculosis and Lung Disease
Background: Improved tuberculosis (TB) screening is urgently needed for human immunodeficiency virus (HIV) infected patients. Methods: An observational, multi-country, cross-sectional study of HIV-infected patients to compare a standardized diagnostic...

Low tuberculosis knowledge among HIV-infected patients in a high HIV prevalence region within Southeast India

Post Date: 
2013-03-21
   |   
Countries: 
India
Publication: 
Journal of the International Association of Providers of AIDS Care
Setting: A private multispecialty hospital in Kakinada, Andhra Pradesh, India. Methods: A survey of knowledge, attitudes, and perceptions adapted from a pretested questionnaire was administered to 128 HIV-infected adults, from July to August 2008.

Tuberculosis in pregnant and postpartum women: Epidemiology, management, and research gaps

Post Date: 
2012-12-15
Publication: 
Clinical Infectious Diseases
Tuberculosis is most common during a woman's reproductive years and is a major cause of maternal-child mortality. National guidelines for screening and management vary widely owing to insufficient data. In this article, we review the available data on (1) the global burden of tuberculosis in...

Safety, tolerability, and pharmacokinetic interactions between single-dose TMC207 and steady-state efavirenz in healthy volunteers: AIDS Clinical Trials Group (ACTG) Study.

Post Date: 
2012-04-15
   |   
Countries: 
United States
Publication: 
Journal of Acquired Immune Deficiency Syndromes
Background: Drug-drug interactions complicate management of coinfection with HIV-1 and Mycobacterium tuberculosis. Bedaquiline (formerly TMC207), an investigational agent for the treatment of tuberculosis, is metabolized by cytochrome P450 (CYP) 3A which may be induced by the antiretroviral...

Symptom screening among HIV-infected pregnant women is acceptable and has high negative predictive value for active tuberculosis

Post Date: 
2011-11-15
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
Clinical Infectious Diseases
Symptom screening is a recommended component of intensified case-finding (ICF) for pulmonary tuberculosis (TB) among HIV-infected individuals. Symptomatic individuals are further investigated to either exclude or diagnose pulmonary TB, thus reducing the number of individuals requiring costly...

QuantiFERON-TB Gold In-Tube for the detection of Mycobacterium tuberculosis infection in children with household tuberculosis contact

Post Date: 
2011-05-05
Publication: 
International Journal of Tuberculosis and Lung Disease
Setting : Improved strategies are needed for detecting Mycobacterium tuberculosis infection in children in TB-endemic settings. Objective : To determine the prevalence of M. tuberculosis infection by tuberculin skin testing (TST) and by the QuantiFERON-TB Gold In-Tube (...

Maternal tuberculosis: a risk factor for mother-to-child transmission of human immunodeficiency virus

Post Date: 
2011-02-01
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
The Journal of Infectious Diseases
Background: Maternal human immunodeficiency virus (HIV) RNA load, CD4 cell count, breast-feeding, antiretroviral use, and malaria are well-established factors associated with mother-to-child transmission (MTCT) of HIV; the role of maternal tuberculosis (TB), however, has not been well...

Tuberculosis in women and children

Post Date: 
2010-12-15
Publication: 
The Lancet
Apart from improvement of tuberculosis control, innovative strategies to advance tuberculosis prevention and treatment in women and children would contribute to the attainment of Millennium Development Goals 4 and 5 by reduction of the mortality rate in young children and women of...

Quantitative analysis of a urine-based assay for lipoarabinomannan in patients with tuberculosis

Post Date: 
2010-08-15
Publication: 
Journal of Clinical Microbiology
Abstract Urinary lipoarabinomannan (LAM) detection is a promising approach for rapid diagnosis of active tuberculosis (TB). In microbiologically confirmed TB patients, quantitative LAM detection results increased progressively with bacillary burden and immunosuppression. Patients with...

Incidence of common opportunistic infections in HIV-infected individuals in Pune, India: analysis by stages of immunosuppression represented by CD4 counts

Post Date: 
2008-07-02
Publication: 
International Journal of Infectious Diseases
Background: Opportunistic infections (OIs) influence the morbidity and mortality due to HIV infections. Data from India on the incidence of OIs among HIV-infected individuals by stages of immunodeficiency are scarce. Methods: Between September 2002 and...

Post-partum TB incidence and mortality among HIV-infected women and their infants in Pune, India 2002-2005

Post Date: 
2007-07-15
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
Clinical Infectious Diseases
Background: In contrast with many other countries, isoniazid preventative therapy is not recommended in clinical care guidelines for human immunodeficiency virus (HIV)-infected persons with latent tuberculosis (TB) in India. Methods: Seven hundred fifteen...

Profile of bone marrow examination in HIV/AIDS patients to detect opportunistic infections, especially tuberculosis

Post Date: 
2005-01-15
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
Indian Journal of Pathology and Microbiology
Morphological evaluation of 140 bone marrow aspirations received in haematopathology laboratory with serologically established HIV infection, along with other relevant special haematological tests, was done during 1st Jan 1999 - 31st Dec 2002 at state government run tertiary care General...

Profile of bone marrow examination in HIV/AIDS patients to detect opportunistic infections, especially tuberculosis

Post Date: 
2005-01-15
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
iIndian Journal of Pathology and Microbiology
Morphological evaluation of 140 bone marrow aspirations received in haematopathology laboratory with serologically established HIV infection, along with other relevant special haematological tests, was done during 1st Jan 1999 - 31st Dec 2002 at state government run tertiary care General...

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