Publications - Tuberculosis

Toward earlier inclusion of pregnant and postpartum women in TB drug trials: consensus statements from an International Expert Panel

Post Date:

2016-01-04

Publication:

Clinical Infectious Diseases

Tuberculosis is a major cause of morbidity and mortality in women of childbearing age (15–44 years). Despite increased tuberculosis risk during pregnancy, optimal clinical treatment remains unclear: safety, tolerability, and pharmacokinetic data for many tuberculosis drugs are lacking, and...

Cost effectiveness of isoniazid preventive therapy for HIV-infected pregnant women in India

Post Date:

2016-01-01

Countries:

India

Clinical Sites:

BJGMC

Publication:

International Journal of Tuberculosis and Lung Disease

Background: India has a high burden of active tuberculosis (TB) and human immunodeficiency virus (HIV) infection. Pregnancy increases the risks of developing TB in HIV-infected women. Isoniazid preventive therapy (IPT) reduces progression to TB, but may increase costs and hepatotoxicity. The...

Pediatric tuberculous meningitis: model-based approach to determining optimal doses of anti-tuberculosis drugs for children

Post Date:

2015-10-22

Countries:

Clinical Sites:

Publication:

Clinical Pharmacology and Therapeutics

Pediatric tuberculous meningitis (TBM) is a highly morbid, often fatal disease. Standard treatment includes isoniazid, rifampin, pyrazinamide, and ethambutol. Current rifampin dosing achieves low cerebrospinal fluid (CSF) concentrations, and CSF penetration of ethambutol is poor. In adult...

RePORT International: advancing tuberculosis biomarker research through global collaboration

Post Date:

2015-10-15

Countries:

Clinical Sites:

Publication:

Clinical Infectious Diseases

Progress in tuberculosis clinical research is hampered by a lack of reliable biomarkers that predict progression from latent to active tuberculosis, and subsequent cure, relapse, or failure. Regional Prospective Observational Research for Tuberculosis (RePORT) International represents a...

Concurrent anemia and elevated CRP predicts HIV clinical treatment failure, including TB, post-antiretroviral therapy initiation

Post Date:

2015-07-01

Countries:

Clinical Sites:

Publication:

Clinical Infectious Diseases

Background: Anemia is a known risk factor for clinical failure following antiretroviral therapy (ART). Notably, anemia and inflammation are interrelated, and recent studies have associated elevated C-reactive protein (CRP), an inflammation marker, with adverse human immunodeficiency virus (...

Efavirenz pharmacokinetics in HIV-infected persons receiving rifapentine and isoniazid for tuberculosis prevention

Post Date:

2015-06-16

Countries:

South Africa

Thailand

United States

Publication:

Clinical Infectious Diseases

Background: Concomitant use of rifamycins to treat or prevent tuberculosis can result in subtherapeutic concentrations of antiretroviral drugs. We studied the interaction of efavirenz with daily rifapentine and isoniazid in human immunodeficiency virus (HIV)-infected individuals receiving a 4...

Vitamin D deficiency and risk of postpartum tuberculosis among HIV-infected breastfeeding mothers in India

Post Date:

2015-03-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

International Journal of Tuberculosis and Lung Disease

Some studies have associated low vitamin D levels with the risk of tuberculosis (TB), but its association in human immunodeficiency virus (HIV) infected mothers in a TB-endemic region has not been well studied. We conducted a nested 1:2 case-control study among HIV-infected mothers in western...

What tuberculosis means for maternal health

Post Date:

2015-03-04

Mrs. Kumar [not her real name] was diagnosed with TB 18 years ago, during her first pregnancy, which ended in miscarriage. She then became depressed and side effects from the TB medications caused her difficulty eating. Three years later, during her second pregnancy, she and her husband were...

C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings

Post Date:

2015-02-26

Countries:

Publication:

PLOS One

Objective: The association between pre-antiretroviral (ART) inflammation and immune activation and risk for incident tuberculosis (TB) after ART initiation among adults is uncertain. Design: Nested case-control study (n = 332) within ACTG PEARLS trial of...

Activism on rifapentine pricing: removing cost barriers to improve the uptake of tuberculosis research innovations

Post Date:

2014-12-21

Publication:

Public Health Action

As recent advances have been made in developing tools to fight tuberculosis (TB), there is also a trend towards increasing advocacy by the civil society for TB research and access. One recent successful effort to increase access to treatment options for TB involved a collaborative effort to...

Complications of tuberculosis

Post Date:

2014-10-15

Publication:

Current Opinion in Infectious Diseases

Purpose of review : Diagnosis and management of tuberculosis (TB) remains challenging and complex because of the heterogeneity of disease presentations. Despite effective treatment, TB disease can lead to significant short-and long-term health consequences. We review potential acute and...

Source case investigation for children with TB disease in Pune, India

Post Date:

2014-08-27

Countries:

India

Clinical Sites:

BJGMC

Publication:

Tuberculosis Research and Treatment

Setting. Contact tracing is broadly encouraged for tuberculosis (TB) control. In many high-burden countries, however, little effort is made to identify contacts of newly diagnosed TB patients. This failure puts children, many of whom live in poor crowded communities, at special risk. ...

Economic challenges associated with tuberculosis diagnostic development

Post Date:

2014-08-15

Publication:

Expert Review of Pharmacoeconomics and Outcomes Research

Tuberculosis remains a global health crisis in part due to underdiagnosis. Technological innovations are needed to improve diagnostic test accuracy and reduce the reliance on expensive laboratory infrastructure. However, there are significant economic challenges impeding the development and...

Cost-effectiveness of rapid susceptibility testing against second line drugs for tuberculosis

Post Date:

2014-06-15

Publication:

International Journal of Tuberculosis and Lung Disease

Background : Drug susceptibility testing (DST) against second-line tuberculosis drugs (SLDs) is essential for improving outcomes among multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB) cases. Objective : To evaluate the potential cost-...

Gender-related barriers and delays in accessing tuberculosis diagnostic and treatment services - Part 2: a systematic review of qualitative studies

Post Date:

2014-05-11

Publication:

Tuberculosis Research and Treatment

Background: Tuberculosis (TB) remains a significant global public health problem with known gender-related (male versus female) disparities. We reviewed the qualitative evidence (written/spoken narrative) for gender-related differences limiting TB service access from symptom onset to treatment...

Barriers and delays in tuberculosis diagnosis and treatment services: does gender matter

Post Date:

2014-04-28

Publication:

Tuberculosis Research and Treatment

Background: Tuberculosis (TB) remains a global public health problem with known gender-related disparities. We reviewed the quantitative evidence for gender-related differences in accessing TB services from symptom onset to treatment initiation. Methods: Following a...

The evolving role of advocacy in tuberculosis

Post Date:

2014-04-02

Publication:

The Lancet Respiratory Medicine

Tuberculosis advocacy has changed the disease from a silent epidemic to one with many voices that seek increased political will and investment in research.1 Tuberculosis advocacy has gained strength as a mechanism to improve research, increase access to new methods to fight tuberculosis, and...

Pregnancy differentially impacts performance of latent tuberculosis diagnostics in a high-burden setting

Post Date:

2014-03-21

Countries:

India

Clinical Sites:

BJGMC

Publication:

PLOS One

Background: Targeted screening for latent TB infection (LTBI) in vulnerable populations is a recommended TB control strategy. Pregnant women are at high risk for developing TB and likely to access healthcare, making pregnancy an important screening opportunity in developing countries. The...

Modifiable risk factors associated with tuberculosis disease in children in Pune, India

Post Date:

2014-02-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

International Journal of Tuberculosis and Lung Disease

Setting: India accounts for the largest burden of tuberculosis (TB) worldwide, with 26% of the world's cases. Objective: To assess the association between novel modifiable risk factors and TB in Indian children. Design: Cases were children aged...

Pediatric tuberculosis in young children in India: a prospective study

Post Date:

2013-11-11

Countries:

India

Clinical Sites:

BJGMC

Publication:

BioMed Research International

Background: India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. Methods: Young children (≤ 5 years) with...

Publications - Tuberculosis

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