BJGMC

Byramjee Jeejeebhoy Government Medical College (BJGMC), and Sassoon General Hospitals (SGH)
Jai Prakash Narayan Road, Near Pune Railway Station
Pune, India 411001
www.bjmcpune.org

About:

Among the top medical schools in India
200 medical students, 130 residents per year; 50 nursing students per year
SGH: State-funded 1500-bed tertiary-care public hospital, 21 outpatient clinics, and links to multiple NGOs in the community
JHU partnership established in 1999 for HIV studies; now investigates other infectious diseases, such as tuberculosis, antimicrobial resistance, noncommunicable diseases, and comorbidities
In 2008, JHU field office established at BJGMC Clinical Research Site: 3 full time Hopkins faculty and 20 staff; 150 BJGMC clinical research staff.
Clinical research as well as leadership and oversight for clinical rotations and field studies

Field Study Administrators:

Dr. Vidya Mave, Clinical Research Site Director
Dr. Sandesh Patil, Student Coordinator
Komal Arora, Senior Financial Administrator
Manisha Mhaske, HR Manager

Studies/Projects
Publications

Evaluation of HIV Disease Burden in Hospitalized Patients at Sassoon General Hospital in Pune, India

Post Date:

2013-11-18

Countries:

India

Clinical Sites:

BJGMC

This study was terminated September 13, 2005. The goal of this project was to conduct both a retrospective and prospective epidemiological study of the burden of HIV disease at Sassoon General Hospital. The specific objectives of the study were to establish the proportion of...

Tuberculosis Noon Conference

Post Date:

2013-10-24

Countries:

Clinical Sites:

This effort ended in 2015. As part of the BJGMC-Johns Hopkins India Fogarty Training Program, from 2013-2015 CCGHE hosted the live Tuberculosis Noon Conference webcast. Led by Drs. Maunank Shah, Jonathan Golub, and Richard Chaisson, these webcast meetings brought together Johns Hopkins TB...

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH)

Post Date:

2013-09-28

Countries:

India

Clinical Sites:

BJGMC

NIRT

Collaboratively funded by the US NIH, India’s Department of Biotechnology [DBT], and Indian Council of Medical Research, the Cohort for TB Research by the Indo-US Medical Partnership (C-TRIUMPH) is an Indo-US research consortium that is part of RePORT India, a countrywide consortium for TB...

Community Home Based India Prevention of Mother to Child Transmission of HIV (COMBIND)

Post Date:

2013-09-02

Countries:

India

Clinical Sites:

BJGMC

This study ended May 14, 2019. CCGHE is assessing whether equipping Community Health Workers with mobile health technology and involving them in technology training and personal empowerment seminars can help prevent mother-to-child...

Impact of Diabetes on TB Treatment Outcomes

Post Date:

2013-02-01

Countries:

India

Clinical Sites:

BJGMC

DY Patil

CCGHE, the JHU Center for TB Research and BJGMC have been awarded a $2.5 million dollar NIH grant (2013-2018) to conduct a study to evaluate treatment outcomes among Indian patients with both diabetes mellitus and active TB. This study is assessing the prevalence of impaired glucose or frank...

Bacterial Antimicrobial Resistance Patterns in Pune, India

Post Date:

2013-01-10

Countries:

India

Clinical Sites:

BJGMC

DY Patil

This study was terminated September 24, 2019. Evaluate etiology of acute fever and bacterial drug resistance patterns among adults and children in India.

Diagnosis of Active Tuberculosis in HIV-infected and Uninfected Young Children in India

Post Date:

2012-07-24

Countries:

India

Clinical Sites:

BJGMC

Tuberculosis (TB) is the most common cause of morbidity/mortality in HIV-infected individuals in India. India has the world's highest burden of HIV and TB, and since children acquire HIV/TB from their caregivers, active TB is highly prevalent (14-67.5%) among HIV-infected young children in...

RePORT India

Post Date:

2012-06-30

Countries:

Clinical Sites:

RePORT India is a joint venture between the Indian and US governments. The Indo-US Vaccine Action Program, a collaboration between the Indian Department of Biotechnology (DBT), the Indian Council of Medical Research (ICMR), and the US NIH, is co-funding six teams of India- and US-based...

C-TRIUMPH Pilot Study: Burden and Risk Factors for Drug-resistant Tuberculosis in Pune, India

Post Date:

2012-05-29

Countries:

India

Clinical Sites:

BJGMC

This pilot study ended in April 2015. Drug resistant TB (MDR-TB and XDR-TB) is increasing worldwide. Although 20% of all global TB cases occur in India, current estimates of the burden of MDR-TB in India are limited. A well-characterized TB clinical cohort, household cohort and control cohort would...

Understanding Challenges and Perspectives of Parents about HIV Disclosures to their Children and Develop a Structured HIV Disclosure Model for Pediatric Age Group

Post Date:

2011-12-08

Countries:

India

Clinical Sites:

BJGMC

This study is terminated. In 2008 an estimated 70,000 children in India were living with HIV, with 21,000 new children are infected each year through mother to child transmission (Singh et al 2008). Increasing availability of antiretroviral treatment (ART) to HIV infected children in India means...

A5273: Multicenter Study of Options for Second-Line Effective Combination Therapy (SELECT)

Post Date:

2011-05-12

Countries:

India

Clinical Sites:

BJGMC

This study was terminated May 2, 2017; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. This was a multinational clinical trial conducted in Brazil, India, Kenya, Malawi, Peru, South Africa, Tanzania, Thailand...

A Prospective Study Evaluating the Role of Cryptococcal Antigen Screening among HIV-infected Adults with Low CD4 Counts

Post Date:

2011-01-01

Countries:

India

Clinical Sites:

BJGMC

This prospective observational study aimed to evaluate the burden of cryptococcal disease among approximately 200 HIV-infected adults with low CD4 cell counts in Pune, India to determine whether a Cryptococcal screening strategy should be the standard of care among patients with advanced HIV...

The Role of Vitamin D in the Development of Active Tuberculosis Disease in Young Children

Post Date:

2010-12-09

Countries:

India

Clinical Sites:

BJGMC

This study was terminated September 2014. Mycobacterium tuberculosis (MTB) results in significant morbidity and mortality worldwide, yet remains difficult to diagnose and manage, particularly in resource constrained settings. Deficiency in vitamin D, a recently recognized...

P1073: Study of Immune Reconstitution Inflammatory Syndrome (IRIS) for International Sites Initiating Highly Active Antiretroviral Therapy (HAART) in Infants and Children < 72 Months of Age

Post Date:

2010-11-15

Countries:

India

Clinical Sites:

BJGMC

This study was terminated April 23, 2015. This was a multi-national study conducted in India, South Africa, and Tanzania under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of Health...

Retrospective Characterization of Clinical and Demographic Data of Pediatric Tuberculosis Patients Treated at BJ Medical College in Pune, India

Post Date:

2010-06-10

Countries:

India

Clinical Sites:

BJGMC

This study ended June 14, 2013.

Hospitalized Pediatric Patients with Pandemic 2009 H1N1 Influenza in India (August-November 2009)

Post Date:

2010-04-10

Countries:

India

Clinical Sites:

BJGMC

This study ended in April 2013. This was a review and collection of data from the medical records of pediatric patients who were admitted to the BJMC/Sassoon General Hospitals with H1N1 influenza during August-November 2009.

A5225: Phase I/II Dose-Finding Study of High-Dose Fluconazole Treatment in AIDS-Associated Cryptococcal Meningitis

Post Date:

2009-04-22

Countries:

India

Clinical Sites:

BJGMC

This trial was terminated in March 2015; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health. This multi-country study was conducted in India, Kenyam Peru, South Africa, Thailand, Uganda, United States, and...

Impact of Malnutrition on HIV Treatment Failure in Resource-limited Settings

Post Date:

2009-04-02

Countries:

India

Clinical Sites:

BJGMC

This study, NWCS 319, was terminated August 20, 2019. Highly active antiretroviral therapy (HAART) has reduced morbidity and mortality among HIV-infected persons worldwide. However, early treatment failure (i.e. WHO stage 3 or 4 illnesses or death...

A5253: Sensitivity and Specificity of Mycobacterium Tuberculosis Screening and Diagnostics in HIV-Infected Individuals

Post Date:

2009-03-19

Countries:

Clinical Sites:

This study was terminated October 15, 2014. An estimated 3 million HIV-infected individuals will enter programs for antiretroviral (ARV) treatment in the coming year, with projected rates of requirement for ARV therapy extending to more than 10 million in sub-Saharan Africa...

P1070: Dose-Finding and Pharmacogenetic Study of Efavirenz in HIV-Infected and HIV/TB Co-Infected Infants and Children ≥ 3 Months to < 36 Months of Age

Post Date:

2008-12-05

Countries:

Clinical Sites:

This study ended March 10, 2015. This multi-country trial was conducted in India, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe, under the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network and funded by the U.S. National Institutes of...

Pediatric tuberculosis in young children in India: a prospective study

Post Date:

2013-11-11

Countries:

India

Clinical Sites:

BJGMC

Publication:

BioMed Research International

Background: India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. Methods: Young children (≤ 5 years) with...

Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253

Post Date:

2013-04-15

Countries:

Clinical Sites:

Publication:

International Journal of Tuberculosis and Lung Disease

Background: Improved tuberculosis (TB) screening is urgently needed for human immunodeficiency virus (HIV) infected patients. Methods: An observational, multi-country, cross-sectional study of HIV-infected patients to compare a standardized diagnostic...

Changes in HIV-1 subtypes B and C genital tract RNA in women and men after initiation of antiretroviral therapy

Post Date:

2013-03-26

Clinical Sites:

BJGMC

Publication:

Clinical Infectious Diseases

Background: Combination antiretroviral therapy (cART) reduces genital tract human immunodeficiency virus type 1 (HIV-1) load and reduces the risk of sexual transmission, but little is known about the efficacy of cART for decreasing genital tract viral load (GTVL) and differences in sex or HIV...

Growth patterns among HIV-exposed infants receiving nevirapine prophylaxis in Pune, India

Post Date:

2012-10-31

Countries:

India

Clinical Sites:

BJGMC

Publication:

BMC Infectious Diseases

Background: India has among the highest rates of infant malnutrition. Few studies investigating the growth patterns of HIV-exposed infants in India or the impact of timing of HIV infection on growth in settings such as India exist. Methods: We used data from...

Pooled individual data analysis of five randomized trials of infant nevirapine prophylaxis to prevent breast-milk HIV-1 transmission

Post Date:

2012-10-19

Countries:

Clinical Sites:

Publication:

Clinical Infectious Diseases

Background: In resource-limited settings, mothers infected with human immunodeficiency virus type 1 (HIV-1) face a difficult choice: breastfeed their infants but risk transmitting HIV-1 or not breastfeed their infants and risk the infants dying of other infectious diseases or...

Vitamin D deficiency is common among HIV-infected breastfeeding mothers in Pune, India, but not associated with mother-to-child HIV transmission

Post Date:

2012-10-01

Countries:

India

Clinical Sites:

BJGMC

Publication:

HIV Clinical Trials

A recent report from Tanzania demonstrated an increased risk of being HIV infected or of dying at birth among children born to breastfeeding mothers with low baseline vitamin D levels. We conducted a nested case-control study among HIV-infected pregnant women in western India to confirm the...

Authors’ response to Hanrahan et al CID article

Post Date:

2012-05-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

Clinical Infectious Diseases

Reply to letter

Predictors of mortality in hospitalized children with pandemic H1N1 influenza 2009 in Pune, India

Post Date:

2012-04-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

Indian Journal of Pediatrics

Objective: To analyse the factors associated with increased mortality among Indian Children with H1N1. Methods: Data were abstracted from available hospital records of children less than 12 y of age, who were admitted to Sassoon General Hospital in Pune, India, with...

Impact of maternal human immunodeficiency virus infection on pregnancy and birth outcomes in Pune, India

Post Date:

2011-12-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

AIDS Care

Little is known about birth outcomes for HIV-infected women in India. We examine maternal and neonatal birth outcomes in HIV-infected women within the context of enhanced pre-natal care associated with a randomized clinical trial conducted in Pune, India. Birth outcomes of 212 HIV-infected...

Symptom screening among HIV-infected pregnant women is acceptable and has high negative predictive value for active tuberculosis

Post Date:

2011-11-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

Clinical Infectious Diseases

Symptom screening is a recommended component of intensified case-finding (ICF) for pulmonary tuberculosis (TB) among HIV-infected individuals. Symptomatic individuals are further investigated to either exclude or diagnose pulmonary TB, thus reducing the number of individuals requiring costly...

High rates of all-cause and gastroenteritis-related hospitalization morbidity and mortality among HIV-exposed Indian infants

Post Date:

2011-07-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

BMC Infectious Diseases

Background: HIV-infected and HIV-exposed, uninfected infants experience a high burden of infectious morbidity and mortality. Hospitalization is an important metric for morbidity and is associated with high mortality, yet, little is known about rates and causes of hospitalization among these...

Twelve month follow-up of the SWEN randomized controlled trials: Differential impact of extended-dose nevirapine on mother-to-child transmission and infant death by maternal CD4 cell count

Post Date:

2011-03-27

Countries:

Clinical Sites:

Publication:

AIDS Care

Objectives: We previously reported combined analysis of 6-week and 6-month endpoints of three randomized controlled trials [Six Week Extended Dose Nevirapine (SWEN) trials] that compared extended-dose nevirapine through 6 weeks of age to single-dose nevirapine to prevent HIV transmission via...

Predictors of retention among men attending STI clinics in HIV prevention programs and research: A case control study in Pune, India

Post Date:

2011-03-11

Countries:

India

Clinical Sites:

BJGMC

Publication:

PLOS One

Background: Retention is critical in HIV prevention programs and clinical research. We studied retention in the three modeled scenarios of primary prevention programs, cohort studies and clinical trials to identify predictors of retention. Methodology/Principal Findings: Men attending Sexually...

Maternal tuberculosis: a risk factor for mother-to-child transmission of human immunodeficiency virus

Post Date:

2011-02-01

Countries:

India

Clinical Sites:

BJGMC

Publication:

The Journal of Infectious Diseases

Background: Maternal human immunodeficiency virus (HIV) RNA load, CD4 cell count, breast-feeding, antiretroviral use, and malaria are well-established factors associated with mother-to-child transmission (MTCT) of HIV; the role of maternal tuberculosis (TB), however, has not been well...

Extended-dose nevirapine to 6 weeks of age for infants to prevent HIV transmission via breastfeeding in Ethiopia, India, and Uganda: an analysis of three randomized controlled trials

Post Date:

2009-07-26

Countries:

Clinical Sites:

Publication:

The Lancet

Background: UNICEF/WHO recommends that infants born to HIV-infected mothers who do not have access to acceptable, feasible, affordable, sustainable, and safe replacement feeding should be exclusively breastfed for at least 6 months. The aim of three trials in Ethiopia, India, and Uganda was...

Nevirapine resistance and breast-milk HIV transmission: effects of single and extended-dose nevirapine prophylaxis in subtype C HIV-infected infants

Post Date:

2009-01-01

Countries:

India

Clinical Sites:

BJGMC

Publication:

PLOS One

Background: Daily nevirapine (NVP) prophylaxis to HIV-exposed infants significantly reduces breast-milk HIV transmission. We assessed NVP-resistance in Indian infants enrolled in the “six-week extended-dose nevirapine” (SWEN) trial who received single-dose NVP (SD-NVP) or SWEN for prevention...

High risk for occupational exposure to HIV and utilization of post-exposure prophylaxis in a teaching hospital in Pune, India

Post Date:

2008-10-21

Countries:

India

Clinical Sites:

BJGMC

Publication:

BMC Infectious Diseases

Background: The risk for occupational exposure to HIV has been well characterized in the developed world, but limited information is available about this transmission risk in resource-constrained settings facing the largest burden of HIV infection. In addition, the feasibility and utilization of...

Repeated pregnancy in HIV positive Indian women with known HIV status

Post Date:

2008-09-29

Countries:

India

Clinical Sites:

BJGMC

Publication:

AIDS Care

HIV-positive women of reproductive age face challenges in decision making related to pregnancy. Understanding factors influencing repeat pregnancies in women with known HIV status are necessary to guide interventions and counseling strategies to better inform and support them. We compared...

Modeling maternal infant HIV transmission in the presence of breast-feeding with an imperfect test

Post Date:

2007-12-15

Countries:

India

Clinical Sites:

BJGMC

Publication:

Biometrics

An important public health question is to determine the probabilities of perinatal HIV transmission and when it occurs, whether antepartum, intrapartum, or postpartum through breastfeeding. However, this is a difficult problem because the presence of HIV infection in an infant can only be...

Low sensitivity of total lymphocyte count as a surrogate marker to identify antepartum and postpartum Indian women who require antiretroviral therapy

Post Date:

2007-11-01

Countries:

India

Clinical Sites:

BJGMC

Publication:

Journal of Acquired Immune Deficiency Syndromes

Background: Some studies support the use of total lymphocyte count (TLC) as a surrogate marker for CD4 cell count to guide antiretroviral therapy (ART) initiation. However, most of these studies have focused on nonpregnant adults. In light of expanding ART access through prevention of mother-...

BJGMC

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