Characterising cause of death among people treated for drug-susceptible TB in India

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The International Journal of Tuberculosis and Lung Disease

Annually, 1.5 million people die of TB.1 India has thehighest burden of TB,1 and in 2020, the case fatality ratio (CFR) among people with drug-susceptible TB was 4.3%.2 Even after treatment, mortality is more
than two-fold higher among people with prior TB compared to the general population.3,4 However, information about cause of death, particularly in India, is limited. Thus, we sought to characterise cause of death among individuals who accessed TBcare.

From 2013 to 2018, we enrolled individuals within 1 week of being diagnosed with drug-susceptible TB at public clinics in Pune and Chennai, India, into two pooled prospective cohorts.5,6 Participants received care according to India’s standard guidelines and were followed up to 18 months post-treatment. Sociodemographic and clinical data were collected at enrolment and microbiological results were tracked. Considering low paediatric mortality, participants,18 years were excluded.

Cox, S. R.; Padmapriyadarsini, C.; Mave, V.; Seth, B.; Thiruvengadam, K. ; Gaikwad, S.; Sahasrabudhe, T. R.; Sane, M.; Tornheim, J. A.; Shrinivasa, B. M.; Lokhande, R.; Barthwal, M. S.; Shivakumar, S. V. B. Y.; Krishnan, S.; Santhappan, R.; Kinikar, A.; Kakrani, A. L.; Paradkar, M.; Bollinger, R. C.; Sekar, K.; Gupte, A. N.; Hanna, L. E.; Gupta, A.; Golub, J. E. Int J Tuberc Lung Dis 27(1):78–80