Evaluation of Longitudinal Blood Culture Isolates from BJ Medical College in Pune, India, 2003-2013

Post Date: 
2014-06-16
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
This study was terminated July 31, 2014. Antibiotic resistance is a serious global problem and is caused by multiple factors which have led to difficulty in the management of life-threatening, multi-drug resistant (MDR) bacterial bloodstream infections. The knowledge of antibiotic resistance...

ART Study 1: Database: Epidemiology of HIV/AIDS and Associated Comorbidities in a Public Antiretroviral Treatment (ART) Clinic at BJGMC in Pune

Post Date: 
2014-06-14
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Hinduja Hospital
Since 2004, the National AIDS Control Program of India has been rolling out free antiretroviral therapy. Byramjee Jeejeebhoy Government Medical College (BJGMC), located in Pune, India, is now the largest HIV clinic in India, with over 26,000 adult and pediatric patients registered since 2005...

Tuberculosis Noon Conference

Post Date: 
2013-10-24
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
DY Patil
Hinduja Hospital
NIRT
This effort ended in 2015. As part of the BJGMC-Johns Hopkins India Fogarty Training Program, from 2013-2015 CCGHE hosted the live Tuberculosis Noon Conference webcast. Led by Drs. Maunank Shah, Jonathan Golub, and Richard Chaisson, these webcast meetings brought together Johns Hopkins TB...

Impact of Diabetes on TB Treatment Outcomes

Post Date: 
2013-02-01
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
DY Patil
CCGHE, the JHU Center for TB Research and BJGMC have been awarded a $2.5 million dollar NIH grant (2013-2018) to conduct a study to evaluate treatment outcomes among Indian patients with both diabetes mellitus and active TB. This study is assessing the prevalence of impaired glucose or frank...

Bacterial Antimicrobial Resistance Patterns in Pune, India

Post Date: 
2013-01-10
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
DY Patil
This study was terminated September 24, 2019. Evaluate etiology of acute fever and bacterial drug resistance patterns among adults and children in India.

BWI CTU: Baltimore-Washington-India Clinical Trials Unit

Post Date: 
2007-02-02
   |   
Countries: 
India
United States
   |   
Clinical Sites: 
BJGMC
Comprising clinical trial sites at Johns Hopkins Medicine in Baltimore, Whitman Walker Health in Washington, DC, and the BJGMC-CCGHE collaboration in Pune, India, the Baltimore-Washington-India Clinical Trials Unit (BWI-CTU) is one of only 25 international HIV/TB clinical trial sites funded by the...

BJGMC-JHU Fogarty HIV-TB Training Program

Post Date: 
2007-01-01
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Funded by the Fogarty International Center at the National Institutes of Health, the JHU Fogarty program has nearly 20 years of success with providing training, professional development, and mentorship to clinicians and scientists in low and middle income countries. CCGHE's latest efforts in...

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Antibiotic utilization and the role of suspected and diagnosed mosquito borne illness among adults and children with acute febrile illness in Pune, India

Post Date: 
2018-05-02
   |   
Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
Clinical Infectious Diseases
Mosquito-borne disease identification is associated with reduced empiric antibiotic use and faster antibiotic discontinuation.

Pyrosequencing to resolve discrepant Xpert MTB/RIF and Mycobacterial Growth Indicator Tube 960

Post Date: 
2018-03-26
   |   
Countries: 
India
   |   
Clinical Sites: 
Hinduja Hospital
Publication: 
Lung India
Lung India: Indo-JHU researchers find that pyrosequencing can clear up discrepancies about drug resistance in TB.

How feasible is pharmaceutical regulation in India?

Post Date: 
2018-01-29
   |   
Countries: 
India
Publication: 
The Lancet Global Health
Lancet Global Health: Dr. Sachin Atre outlines factors that complicate pharmaceutical regulation in India, which is a component of WHO's Global Antimicrobial Resistance Action Plan.

Of testing and treatment: Implications of implementing new regimens for multidrug-resistant tuberculosis

Post Date: 
2017-10-01
Publication: 
Clinical Infectious Diseases
A novel, shorter-course regimen for treating multidrug-resistant (MDR) tuberculosis was recently recommended by the World Health Organization. However, the most appropriate use of drug susceptibility testing (DST) to support this regimen is less clear. Implementing countries must therefore...

High burden of antimicrobial resistance and mortality among adults and children with community-onset bacterial infections in India

Post Date: 
2017-04-15
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Countries: 
India
   |   
Clinical Sites: 
BJGMC
Publication: 
Journal of Infectious Diseases
Of 133 isolates from 115 patients, 50% were multi-drug resistant; of 33 isolates tested for carbapenem susceptibility, 36% were resistant.

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

Post Date: 
2017-03-24
Publication: 
The Lancet Respiratory Medicine
Global tuberculosis incidence has declined marginally over the past decade, and tuberculosis remains out of control in several parts of the world including Africa and Asia. Although tuberculosis control has been effective in some regions of the world, these gains are threatened by the increasing...

Drug-resistant tuberculosis in 2017: at a crossroads

Post Date: 
2017-03-15
Publication: 
Lancet Respiratory Medicine
In The Lancet Respiratory Medicine, Dheda and colleagues present one of the most comprehensive pictures to date of the global epidemic of drug-resistant tuberculosis. This comes at a time of increasing awareness of antimicrobial resistance as a global threat, and Mycobacterium tuberculosis...

Management and control of multidrug-resistant tuberculosis (MDR-TB): addressing policy needs for India

Post Date: 
2016-05-06
   |   
Countries: 
India
Publication: 
Journal of Public Health Policy
Multidrug-resistant tuberculosis (MDR-TB) challenges TB control efforts because of delays in diagnosis plus its long-term treatment which has toxic effects. Of TB high-incidence countries, India carries the highest burden of MDR-TB cases. We describe policy issues in India concerning MDR-TB...

Blood stream infections

Post Date: 
2014-07-01
Publication: 
BioMed Research International
Blood stream infection (BSI) is one of the most devastating preventable complications in Critical Care Units. It has far-reaching consequences resulting in prolonged length of hospital-stay, high costs to the individual and exchequer, and, in many instances, loss of life. Although exact rates...

Patterns of TB drug-resistance in a tertiary care facility in Pune, India

Post Date: 
2013-07-18
   |   
Countries: 
India
Publication: 
Clinical Microbiology
Introduction:Globally, the emergence of multi-drug resistant tuberculosis (MDRTB) (defined as resistance to isoniazid (INH) and rifampicin (RIF) and extensively drug resistant (XDR-TB) (defined as resistance to INH, RIF, any fluoroquinolone and to at least one of the three injectable second...

Tuberculosis in pregnant and postpartum women: Epidemiology, management, and research gaps

Post Date: 
2012-12-15
Publication: 
Clinical Infectious Diseases
Tuberculosis is most common during a woman's reproductive years and is a major cause of maternal-child mortality. National guidelines for screening and management vary widely owing to insufficient data. In this article, we review the available data on (1) the global burden of tuberculosis in...

Tuberculosis in women and children

Post Date: 
2010-12-15
Publication: 
The Lancet
Apart from improvement of tuberculosis control, innovative strategies to advance tuberculosis prevention and treatment in women and children would contribute to the attainment of Millennium Development Goals 4 and 5 by reduction of the mortality rate in young children and women of...

One-, two-, and three-class resistance among HIV-infected patients on antiretroviral therapy in private care clinics: Mumbai, India

Post Date: 
2010-01-26
   |   
Countries: 
India
Publication: 
AIDS Research and Human Retroviruses
HIV-infected patients receiving antiretroviral (ARV) therapy (ART) in India are not all adequately virally suppressed. We analyzed ARV drug resistance in adults receiving ART in three private clinics in Mumbai, India. HIV viral load was measured in 200 patients with the Roche AMPLICOR HIV-1 Monitor...

Hematogenous osteomyelitis mimicking osteosarcoma due to Community Associated Methicillin-Resistant Staphylococcus aureus

Post Date: 
2007-06-15
Publication: 
Infection
Community Associated Methicillin - Resistant Staphylococcus aureus (CA-MRSA) is an emerging pathogen with increasing clinical significance. Initially recognized as a cause of skin and soft tissue infections, it has soon been shown to cause life threatening illnesses. We describe two cases of...

Antimicrobial-resistant Shigella sonnei: Limited antimicrobial treatment options for children and challenges of interpreting in vitro azithromycin susceptibility

Post Date: 
2005-06-15
Publication: 
Journal of Pediatric Infectious Diseases
Background: Antimicrobial-resistant Shigella sonnei is a growing problem in the United States and poses treatment challenges particularly among children. Azithromycin is recommended as an alternative oral agent for shigellosis. Methods: All isolates of Shigella...

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