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Intestinal barrier dysfunction and microbial translocation in HIV-infected pregnant women is associated with preterm birth

Post Date:

2018-03-24

Countries:

India

Clinical Sites:

BJGMC

NIRT

Publication:

Clinical Infectious Diseases

Our results show select immune markers can identify women at higher risk for PTB in HIV-1-infected populations and suggest modulating gut barrier integrity and microbial translocation may affect PTB.

Mobile phone incentives for childhood immunizations in rural India

Post Date:

2018-03-19

Countries:

India

Publication:

Pediatrics

In Pediatrics: Incentives and technology can improve immunization coverage in young children in resource-poor settings.

How feasible is pharmaceutical regulation in India?

Post Date:

2018-01-29

Countries:

India

Publication:

The Lancet Global Health

Lancet Global Health: Dr. Sachin Atre outlines factors that complicate pharmaceutical regulation in India, which is a component of WHO's Global Antimicrobial Resistance Action Plan.

Gender-based violence screening methods preferred by women visiting a public hospital in Pune, India

Post Date:

2018-01-22

Countries:

India

Clinical Sites:

BJGMC

Publication:

BMC Womens Health

BMC Womens Health : In our study, 23% of women reported experiencing gender based violence, and 90% reported they had never been asked about it in the healthcare setting.

Secondhand smoke exposure and validity of self-report in low-income women and children in India

Post Date:

2018-01-10

Countries:

India

Publication:

Pediatrics

Pediatrics: Dr. Jessica Elf and colleagues evaluated the validity of standard self-reported measures for secondhand smoke (SHS) exposure among women and children in urban India.

How reliable and valid are the self-reports on sexual behavior among HIV discordant couples from Pune, India?

Post Date:

2018-01-01

Countries:

India

Publication:

Psychology, Health, and Medicine

Reliability of self-reported sexual and safe sex behavior among heterosexual HIV discordant couples was assessed by matching individual responses of couples to a common set of questions and validated by matching with pregnancy and seroconversion during study period. Demographic, clinical and...

Suboptimal antituberculosis drug concentrations and outcomes in small and HIV‐coinfected children in India: Recommendations for dose modifications

Post Date:

2017-12-16

Countries:

India

Publication:

Clinical Pharmacology and Therapeutics

This work aimed to evaluate the once-daily antituberculosis treatment as recommended by the new Indian pediatric guidelines. Isoniazid, rifampin, and pyrazinamide concentration-time profiles and treatment outcome were obtained from 161 Indian children with drug-sensitive tuberculosis...

Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis

Post Date:

2017-12-07

Countries:

India

Clinical Sites:

BJGMC

NIRT

Publication:

PLOS One

PLOS One: Mave and colleagues compared TB drug exposure in plasma and hair samples among a small cohort of children.

Suboptimal anti-tuberculosis drug concentrations and outcomes in small and HIV coinfected children in India: recommendations for dose modifications

Post Date:

2017-12-01

Countries:

India

Clinical Sites:

NIRT

Publication:

Clinical Pharmacology and Therapeutics

This work aimed to evaluate the once-daily anti-tuberculosis treatment as recommended by the new Indian pediatric guidelines. Isoniazid, rifampin and pyrazinamide concentration-time profiles and treatment outcome were obtained from 161 Indian children with drug-sensitive tuberculosis...

Prevalence of dysglycemia and clinical presentation of pulmonary tuberculosis in Western India

Post Date:

2017-12-01

Countries:

India

Clinical Sites:

BJGMC

Publication:

International Journal of Tuberculosis and Lung Disease

Objectives: To estimate the prevalence and risk factors of pre-diabetes mellitus (DM) and DM, and its associations with the clinical presentation of tuberculosis (TB). Design: Screening for DM was conducted among adults (age  18 years) with confirmed TB between December 2013 and...

People with tuberculosis falling through the cracks

Post Date:

2017-11-01

Countries:

India

Publication:

National Medical Journal of India

India accounts for approximately one-quarter of the estimated global burden of TB and MDR-TB. [4] Achieving the 2015 WHO End TB Strategy[5] and the latest Government of India target of TB elimination by 2025[6] will require substantial efforts and funding to continue to improve TB care in...

Risk factors for early mortality on antiretroviral therapy in advanced HIV-infected adults

Post Date:

2017-10-23

Countries:

India

Clinical Sites:

BJGMC

Publication:

AIDS

Background: Many HIV-infected individuals present with advanced HIV disease. These patients are at high risk of death after antiretroviral therapy (ART) initiation, but risk factors for death in these patients are unclear. Methods: We used data from a multisite randomized trial...

Of testing and treatment: Implications of implementing new regimens for multidrug-resistant tuberculosis

Post Date:

2017-10-01

Publication:

Clinical Infectious Diseases

A novel, shorter-course regimen for treating multidrug-resistant (MDR) tuberculosis was recently recommended by the World Health Organization. However, the most appropriate use of drug susceptibility testing (DST) to support this regimen is less clear. Implementing countries must therefore...

Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016

Post Date:

2017-09-16

Publication:

The Lancet

Abstract Background: Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to...

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Post Date:

2017-09-16

Publication:

The Lancet

Abstract Background: As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD...

Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016

Post Date:

2017-09-12

Publication:

The Lancet

Abstract Background: The UN's Sustainable Development Goals (SDGs) are grounded in the global ambition of "leaving no one behind". Understanding today's gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of populations. As...

Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015

Post Date:

2017-07-15

Publication:

The Lancet

Abstract Background: National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). Previous analyses of mortality amenable to...

A qualitative study exploring factors influencing clinical decision-making for influenza-like illness in Solapur city, Maharashtra, India

Post Date:

2017-07-03

Countries:

India

Publication:

Anthropology and Medicine

Abstract The co-existence of different types of medical systems (medical pluralism) is a typical feature of India's healthcare system. For conditions such as influenza-like illness (ILI), where non-specific disease signs/symptoms exist, clinical reasoning in the context of medical...

Cardiovascular risk in an HIV-infected population in India

Post Date:

2017-07-03

Countries:

India

Clinical Sites:

BJGMC

Publication:

Heart Asia

Findings: HIV+ Indian patients who had cardiovascular disease at a younger age appear to be at imminent risk for morbidity.

Constituent variation in smokeless tobacco purchased in Mumbai, India

Post Date:

2017-07-01

Countries:

India

Publication:

Tobacco Regulatory Science

Objectives: Worldwide, smokeless tobacco products vary greatly in their formulations and chemical composition. Understanding of toxic and carcinogenic constituent variations in such products can provide valuable insights for the development of effective tobacco control policies. In this study...