India

With a population of more than one billion, India is the second largest country in the world, represents 16% of the global population, and the national average for life expectancy is only 65 years. India leads the world in the largest absolute burden of TB, ranks third for HIV (behind South Africa and Nigeria), and ranks second for diabetes. The country receives funding to support HIV/AIDS prevention, treatment and care programs under the US President's Emergency Plan for AIDS Relief (PEPFAR).

Our Indo-JHU Clinical Research Partnership is dedicated to reversing poor patient outcomes. With operations based in Pune, our extensive research portfolio is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya Mave, Dr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and, in addition to our memberships in consortia with many esteemed Indian research institutions, we have formal agreements with:

Byramjee Jeejeebhoy Government Medical College, and Sassoon General Hospital (BJGMC). Pune, India
DY Patil Medical College, Hospital and Research Center. Pune, India
National Institute for Research in Tuberculosis. Chennai, India
PD Hinduja Hospital and Medical Group. Mumbai, India
Medanta The Medicity. Gurgaon, India
KEM Hospital. Pune, India
Bharati Vidyapeeth Medical College. Pune, India

CCGHE WORK IN INDIA

Publications

Maternal pneumococcal capsular IgG antibodies and transplacental transfer are lower in South Asian HIV-infected mother-infant pairs

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2014-03-14

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Vaccine

Background: Our understanding of the mother-to-child transfer of serotype-specific pneumococcal antibodies is limited in non-immunized, HIV-positive women. Methods: We compared geometric mean antibody concentrations (GMCs), geometric mean transplacental...

Modifiable risk factors associated with tuberculosis disease in children in Pune, India

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2014-02-15

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International Journal of Tuberculosis and Lung Disease

Setting: India accounts for the largest burden of tuberculosis (TB) worldwide, with 26% of the world's cases. Objective: To assess the association between novel modifiable risk factors and TB in Indian children. Design: Cases were children aged...

Improving diagnostic capability for HPV disease internationally within the NIH-NIAID-Division of AIDS Clinical Trial Networks

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2013-12-15

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American Journal of Clinical Pathology

OBJECTIVES: To evaluate an external quality assurance (EQA) program for the laboratory diagnosis of human papillomavirus (HPV) disease that was established to improve international research capability within the Division of AIDS at the National Institute of Allergy and Infectious Disease-supported...

Pediatric tuberculosis in young children in India: a prospective study

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2013-11-11

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BioMed Research International

Background: India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. Methods: Young children (≤ 5 years) with...

HIV/AIDS education in traditional Indian systems of medicine: faculty perspectives

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2013-10-24

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Journal of Traditional Medicine and and Clinical Naturopathy

In India, HIV-infected individuals face numerous challenges in their search for treatments. Currently, western allopathic medicine (hereinafter ‘biomedicine’) offers antiretroviral therapy (ART) for HIV/AIDS and associated co-morbidities that have prolonged survival and improved quality of...

India’s new policy to protect research participants

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2013-07-31

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The BMJ

Editorial Introduction: India, the country with the largest disease burden in the world,1 is now a major international hub for clinical research. However, a recent policy that was meant to mitigate important ethical concerns may have profound and unintended consequences for public health and...

Patterns of TB drug-resistance in a tertiary care facility in Pune, India

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2013-07-18

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Clinical Microbiology

Introduction:Globally, the emergence of multi-drug resistant tuberculosis (MDRTB) (defined as resistance to isoniazid (INH) and rifampicin (RIF) and extensively drug resistant (XDR-TB) (defined as resistance to INH, RIF, any fluoroquinolone and to at least one of the three injectable second...

India's conditional cash transfer programme (the JSY) to promote institutional birth: Is there an association between institutional birth proportion and maternal mortality?

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2013-06-27

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PLoS One

Abstract Background: India accounts for 19% of global maternal deaths, three-quarters of which come from nine states. In 2005, India launched a conditional cash transfer (CCT) programme, Janani Suraksha Yojana (JSY), to reduce maternal mortality ratio (MMR) through promotion of...

Effective coverage of institutional deliveries under the Janani Suraksha Yojana programme in high maternal mortality provinces of India: analysis of data from an annual health survey

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2013-06-17

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The Lancet

Abstract Background Three-quarters of India's maternal deaths come from nine (of 35) provinces. In 2005, the government launched a conditional cash transfer programme, Janani Suraksha Yojana (JSY), to reduce maternal mortality through promotion of institutional deliveries (ID)...

Assessment of Gutka ban in Maharashtra: findings from a focus group discussion

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2013-06-11

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International Journal of Head & Neck Surgery

According to Global Adult Tobacco Survey (GATS) India 2009-2010, around 8.3% (13.4% among male and 2.5% amongfemale) of people in Maharashtra are gutka users. Gutkaconsumption not only causes oral cancer, but has also beenlinked with development of oral submucous fibrosis, aprecancerous lesion...

Screening for pulmonary tuberculosis in HIV-infected individuals: AIDS Clinical Trials Group Protocol A5253

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2013-04-15

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International Journal of Tuberculosis and Lung Disease

Background: Improved tuberculosis (TB) screening is urgently needed for human immunodeficiency virus (HIV) infected patients. Methods: An observational, multi-country, cross-sectional study of HIV-infected patients to compare a standardized diagnostic...

Low tuberculosis knowledge among HIV-infected patients in a high HIV prevalence region within Southeast India

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2013-03-21

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Journal of the International Association of Providers of AIDS Care

Setting: A private multispecialty hospital in Kakinada, Andhra Pradesh, India. Methods: A survey of knowledge, attitudes, and perceptions adapted from a pretested questionnaire was administered to 128 HIV-infected adults, from July to August 2008.

Availability of treatment for eclampsia in public health institutions in Maharashtra, India

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2013-03-15

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Journal of Health, Population, and Nutrition

Abstract Severe pre-eclampsia and eclampsia are common causes of maternal deaths worldwide and more so in developing countries. Magnesium sulphate (MgSO4) is now the most-recommended drug of choice to treat these conditions. Despite favourable policies for the use of MgSO4...

Correlates of lower comprehension of informed consent among participants enrolled in a cohort study in Pune, India

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2013-03-15

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International Health

Background: Optimum comprehension of informed consent by research participants is essential yet challenging. This study explored correlates of lower comprehension of informed consent among 1334 participants of a cohort study aimed at estimating HIV incidence in Pune, India. ...

Nutritional status and childhood growth among Korku and Warli tribes of Maharashtra: anthropometric perspective

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2013-01-01

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Explorations in Medical Anthropology

Nutritional status and childhood growth among Korku and Warli tribes of Maharashtra: anthropometric perspective.

Contracting in specialists for emergency obstetric care—does it work in rural India?

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2012-12-31

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BMC Health Services Research

Abstract Background: Contracting in private sector is promoted in developing countries facing human resources shortages as a challenge to reduce maternal mortality. This study explored provision, practice, performance, barriers to execution and views about contracting in...

Growth patterns among HIV-exposed infants receiving nevirapine prophylaxis in Pune, India

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2012-10-31

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BMC Infectious Diseases

Background: India has among the highest rates of infant malnutrition. Few studies investigating the growth patterns of HIV-exposed infants in India or the impact of timing of HIV infection on growth in settings such as India exist. Methods: We used data from...

Pooled individual data analysis of five randomized trials of infant nevirapine prophylaxis to prevent breast-milk HIV-1 transmission

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2012-10-19

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Clinical Infectious Diseases

Background: In resource-limited settings, mothers infected with human immunodeficiency virus type 1 (HIV-1) face a difficult choice: breastfeed their infants but risk transmitting HIV-1 or not breastfeed their infants and risk the infants dying of other infectious diseases or...

Vitamin D deficiency is common among HIV-infected breastfeeding mothers in Pune, India, but not associated with mother-to-child HIV transmission

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2012-10-01

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HIV Clinical Trials

A recent report from Tanzania demonstrated an increased risk of being HIV infected or of dying at birth among children born to breastfeeding mothers with low baseline vitamin D levels. We conducted a nested case-control study among HIV-infected pregnant women in western India to confirm the...

Evaluation of a multimodal, distance learning HIV management course for clinical care providers in India

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2012-10-01

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Journal of the International Association of Providers of AIDS Care

Distance learning is an important tool for training HIV health workers. However, there is limited evidence on design and evaluation of distance learning HIV curricula and tools. We therefore designed, implemented, and evaluated a distance learning course on HIV management for clinical care...

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