Research News

August 12, 2022

Dr. Shivakumar and his group discovered that a high proportion of patients classified as EPTB in India have concomitant PTB. Their results support the need for improved symptom and CXR screening, and recommends routine sputum TB microbiology screening of all Indian patients with EPTB.

Clinical Research

Leadership
Our Indo-JHU Clinical Research Partnership is located in Pune and is directed by Dr. Amita Gupta (Baltimore, MD), with onsite direction from Dr. Vidya Mave, Dr. Nishi Suryavanshi, and Dr. Nikhil Gupte (Pune). The Indo-JHU Partnership employs more than 200 people and in addition to our memberships in consortia with many esteemed Indian research institutions, we have formal agreements with:
 
 

Transcriptomic and Metabolomic Analysis of Microbiologically Confirmed Pediatric Tuberculosis Patients and Uninfected Household Contacts

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2016-09-01
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This study was terminated in June 2020. This study is using stored samples from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB...

Establishing an Observational Cohort Database for Patient Care and Research at the Hinduja Hospital Chest Clinic

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2016-08-30
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India has the largest burden of global tuberculosis (TB), accounting for one quarter of the total number of cases reported. Together with South Africa, India sees one-third of the total number of deaths from TB. Drug-resistant strains of the disease are also on the rise, with India having one...

Measuring TB Drugs in Hair as a Tool to Monitor Adherence, Exposure and Response in Patients with HIV

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2016-08-16
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Our study will examine whether hair levels of two key first line tuberculosis drugs will be useful markers to identify individuals at highest risk of treatment failure in active tuberculosis. Our study aims to provide a lowcost clinical tool using hair that can be noninvasively...

Adherence to Indian National Guidelines for Isoniazid Chemoprophylaxis among Pediatric Contacts of Pulmonary Tuberculosis Cases

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2016-07-06
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This study was terminated June 19, 2019. The primary objective of the study was to assess the implementation of the Indian Revised National Tuberculosis Programme's (RNTCP) guidelines regarding isoniazid preventive treatment (IPT) for children under 6 years of age who had been in contact with...

TB and Pregnancy Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis: Nested Study on Temporal Dynamics of Gut Microbiota in HIV Infected Pregnant Women

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2016-07-05
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This is a nested prospective longitudinal cohort study of 35 HIV-infected and 35 HIV-noninfected pregnant women who are part of the parent study “Impact of Immune Changes of HIV and Stages of Pregnancy on Tuberculosis." The objectives are to: Determine the association...

A Randomized Therapeutic Interventional Comparative Study between Three Different Modalities of Paediatric Antitubercular Treatment

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2016-06-13
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This study was terminated July 6, 2019. It was funded by the Fogarty International Center at the U.S. National Institutes of Health. This study evaluated three different TB treatment regimens in children attending Sassoon General Hospital in Pune, India. A...

Optimal Algorithmic Diagnosis of Genital TB among HIV-infected and Uninfected Infertile Women

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2016-05-26
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This study was terminated March 2020. It was funded by the Fogarty International Center at the U.S. National Institutes of Health. There is a lack of a set protocol universally for diagnosis of genital TB, and for Indian hospitals, India's Revised National...

Whole Genome Sequencing and Trek Sensititre Testing of Stored Isolates of Drug-resistant Tuberculosis from a Clinical Cohort at Hinduja Hospital, Mumbai

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2016-05-02
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Among HIV-positive TB patients presenting to Médecins San Frontières (MSF) clinics in Mumbai, 78% carried MDR-TB strains, with nearly half also found to have additional drug resistance. A previously published cohort of 202 patients cared for at these MSF clinics have enrolled in a...

Barriers to Early Treatment Initiation in Childhood Tuberculosis in High Incidence Setting

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2016-04-21
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This study was terminated October 25, 2019. Funded by the Fogarty International Center and led by PI Dr. Chhaya Tukaram Valvi, the aim of this study is to evaluate the time to treatment initiation and barriers to early treatment initiation in childhood tuberculosis. TB...

Barriers to Implementation of Isoniazid Preventive Treatment (IPT) in Pediatric Contacts of Sputum Positive Adults with Tuberculosis

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2016-03-24
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This study was terminated January 3, 2019. It was funded by the Fogarty International Center at the U.S. National Institutes of Health. Young children infected with M.tuberculosis can rapidly progress to pulmonary and extrapulmonary disease with high rates of mortality and...

The Human Virome in Health and Disease

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2016-02-21
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This study was terminated in September 2020. This study is part of the Antimicrobial Resistance study referenced below, Some samples were used from the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH), under the Regional...

Whole Genome Sequencing of Clinical Isolates from Patients with Multidrug Resistant Tuberculosis in India 

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2015-11-12
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This study was terminated August 9, 2019. Comparative genomic analysis using whole genome sequencing (WGS) offers an opportunity to understand the specific mutations associated with drug resistance and the phenotypic behavior of TB. As treatment programs incorporate more...

Residual Respiratory Impairment Following Pulmonary Tuberculosis

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2015-09-13
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This study is conducted by the Cohort for Tuberculosis Research by the Indo-US Medical Partnership (C-TRIUMPH) under the Regional Prospective Observational Research for Tuberculosis (RePORT) Network, an international TB consortium. Many TB patients have...

A5300/IMPAACT2003: Study of MDR TB Cases and Their Household Contacts: Operational Feasibility to Inform PHOENIx Trial Design

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2015-09-01
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This clinical trial was terminated July 18, 2017. It was a study conducted under both the AIDS Clinical Trial Group (ACTG) and the the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network, and funded by the U.S. National Institutes of Health. Dr...

Prevalence Survey of Risk Factors for Tuberculosis and Non-communicable Diseases in an HIV-positive Population in Pune, India

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2015-08-17
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This study is conducted under the TREAT Asia Network and funded by amfAR. The primary objective of this study is to assess the prevalence of risk factors for tuberculosis and non-communicable diseases (NCDs)--coronary artery disease and diabetes mellitus--...

A5290: A Randomized, Phase 2b Study of a Double-Dose Lopinavir/Ritonavir-Based Antiretroviral Regimen with Rifampin-Based Tuberculosis Treatment versus a Standard-Dose Lopinavir/Ritonavir-Based Antiretroviral Regimen with Rifabutin-Based Tuberculosis...

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2015-07-07
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This study was terminated February 23, 2016; it was conducted under the AIDS Clinical Trials Group (ACTG) and funded by the U.S. National Institutes of Health.. Full Title: A5290, A Randomized, Phase 2b Study of a Double-Dose Lopinavir/Ritonavir-Based Antiretroviral Regimen...

Bacterial Antimicrobial Resistance Patterns in Pune, India: Substudy on Community Health-Seeking Behavior Among Patients Admitted with Acute Febrile Illness

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2015-05-28
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Objectives: To describe the patterns of health-care seeking behavior and prior outpatient care among patients admitted with acute febrile illness to Sassoon Hospital To determine the effects of outpatient behaviors and prior treatments on the antimicrobial...

Barriers for Intervention to Prevent Occupationally Acquired Tuberculosis in Healthcare Workers

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2015-05-21
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This study was terminated April 20, 2017; it was funded by the Fogarty International Center at the U.S. National Institutes of Health. Observational study to assess the current status of implementation of interventions for preventing occupationally acquired...

Risk of Tuberculosis among Health Care Workers and Trainees in a Tertiary-care Hospital in Pune, India

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2015-04-15
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This study was terminated April 24, 2018. It was funded by the Fogarty International Center at the U.S. National Institutes of Health. A retrospective study of health care workers (HCWs) was conducted by investigators of the Byramjee Jeejeebhoy Medical and...

Predictive Value of TB-symptom Screen in HIV-infected and HIV-uninfected Pregnant Women in Pune, India

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2014-10-28
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This study was terminated July 17, 2017. This is a cross sectional observational study will be conducted at BJGMC to establish what the predictive value of the WHO TB symptom screen is in pregnant women in India. We hypothesize that the WHO TB symptom...

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Female global health leadership: Data-driven approaches to close the gender gap

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2019-02-09
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The Lancet
Lancet article investigates gender-based challenges of female health trainees and professionals and identifies interventions

Few eligible for the newly recommended short course MDR-TB regimen at a large Mumbai private clinic

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2019-01-28
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BMC Infectious Diseases
BACKGROUND: India has the world's highest tuberculosis burden, and Mumbai is particularly affected by multidrug resistant tuberculosis (MDR-TB). WHO recommends short, intensive treatment ("Short Course") for previously untreated pulmonary MDR-TB patients but does not require universal...

Symptom screening for active tuberculosis in pregnant women living with HIV

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2019-01-24
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Cochrane Database of Systematic Reviews
This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows: To assess the accuracy of the four-symptom screen (cough, fever, night sweats, or weight loss) for identifying active TB in pregnant PLHIV who are screened in an outpatient or community setting...

Is there a connection between gestational diabetes, human immunodeficiency virus infection, and tuberculosis?

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2019-01-01
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International Journal of Tuberculosis and Lung Disease
IJTLD article reviews the epidemiology and immunology of gestational diabetes and finds there's a lot we don't know about interactions between diabetes, pregnancy, and tuberculosis in both HIV+/- women

Building capacity for advances in tuberculosis research: Proceedings of the third RePORT International Meeting. Tuberculosis (Edinb)

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2018-12-15
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Tuberculosis (Edinb)
Abstract RePORT International is a global network of research sites in India, Brazil, Indonesia, South Africa, China, and the Philippines dedicated to collaborative tuberculosis research in the context of HIV. A standardized research protocol (the Common Protocol) guides the enrollment...

Multiplex-PCR to detect pAmpC β-lactamases among Enterobacteriaceae at a tertiary care laboratory in Mumbai, India

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2018-12-13
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Microbiology
Drug-resistance due to AmpC β-lactamases represents a growing problem worldwide. In this study, a previously collected sample of 108 cefoxitin-resistant clinical isolates was assessed for AmpC β-lactamase production through routine phenotypic testing and double-disc cefoxitin/cloxcallin (DD-CC),...

The global landscape of tuberculosis therapeutics

Post Date: 
2018-11-07
Publication: 
Annual Review of Medicine
Abstract Tuberculosis (TB) is one of the oldest infections afflicting humans yet remains the number one infectious disease killer worldwide. Despite decades of experience treating this disease, TB regimens require months of multidrug therapy, even for latent infections...

Drug-resistant Enterobacteriaceae colonization is associated with healthcare utilization and antimicrobial use among inpatients in Pune, India

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2018-10-04
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BMC Infectious Diseases
BACKGROUND: Healthcare exposure may increase drug-resistant Enterobacteriaceae colonization risk. Nascent antimicrobial stewardship efforts in low- and middle-income countries require setting-specific data. We aimed to evaluate risk factors for inpatient drug resistant...

Barriers to screening and isoniazid preventive therapy for child contacts of tuberculosis patients

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2018-10-01
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International Journal of Tuberculosis and Lung Disease
Universal, timely TB screening and IPT for exposed children are urgently needed to reduce pediatric TB in India

Inflammation and micronutrient biomarkers predict clinical HIV treatment failure and incident active TB in HIV-infected adults: a case-control study

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2018-09-24
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BMC Medicine
Factors identified through exploratory factor analysis were associated with adverse outcomes in HIV-infected individuals.

Report of the Technical Consultation on Advances in Clinical Trial Design for Development of New TB Treatments

Post Date: 
2018-09-17
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WHO Task Force on Introduction of New TB Drugs and Treatment Regimens
Dr. Amita Gupta was a member of this TB technical consultation, convened in March 2018 in Switzerland.

Ovarian mass - tuberculosis or malignancy? Need for early intensified evaluation

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2018-09-14
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EXCLI Journal
Letter to the Editor Dear Editor, We read with interest the case report by Chien et al. on Peritoneal Tuberculosis (TB) mimicking ovarian cancer (Chien et al., 2016[1]). We want to congratulate the authors on this case report. We encountered a similar case in our clinical setting in western India...

The association of household fine particulate matter and kerosene with tuberculosis in women and children in Pune, India

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2018-09-07
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Occupational and Environmental Medicine
Use of kerosene cooking fuel is positively associated with TB in women and children in our analysis using reported sources of exposure.

Challenges and opportunities for outreach workers in the Prevention of Mother to Child Transmission of HIV (PMTCT) program in India

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2018-09-04
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PLoS One
PLoS One: Prevention of Mother-to-Child Transmission of HIV program in India is one of the largest in the world, and it relies on outreach workers. Our study looked at challenges and opportunities for outreach workers.

Failure in TB control: why should the rapid diagnostic test bear the blame?

Post Date: 
2018-09-01
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International Journal of Tuberculosis and Lung Disease
Dr. Sachit Atre's correspondence published in the International Journal of Tuberculosis and Lung Disease.

Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003)

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2018-09-01
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International Journal of Tuberculosis and Lung Disease
Current guidelines recommend evaluation of the household contacts of individuals with multidrug-resistant tuberculosis; however, implementation of this policy is challenging.

The effect of diabetes mellitus on the pharmacokinetics and pharmacodynamics of tuberculosis treatment

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2018-08-20
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Antimicrobial Agents and Chemotherapy
DM and higher HbA1c increased the risk of not achieving therapeutic targets for pyrazinamide, but higher pyrazinamide concentrations were asociated with worse microbiologic and clinical outcomes

Challenges of TB and co-treatment: updates and insights

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2018-08-04
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Current Opinion in HIV and AIDS
PURPOSE OF REVIEW: In the past few years, tuberculosis (TB) has overtaken HIV as the infectious disease with the highest global mortality. Successful management of this syndemic will require improved diagnostic tests, shorter preventive therapies, and more effective treatments,...

Tuberculin skin test and QuantiFERON-Gold In Tube assay for diagnosis of latent TB infection among household contacts of pulmonary TB patients in high TB burden setting

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2018-08-01
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PLoS One
World Health Organization (WHO) recommends systematic screening of high-risk populations, including household contacts (HHCs) of adult pulmonary tuberculosis (TB) patients, as a key strategy for elimination of TB. QuantiFERON-TB Gold In-Tube (QFT-GIT) assay and tuberculin skin test (TST) are two commonly used tools for the detection of latent tuberculosis infection (LTBI) but may yield differential results, affecting eligibility for TB preventive therapy.

Trends in HbA1c levels and implications for diabetes screening in tuberculosis cases undergoing treatment in India

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2018-07-01
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International Journal of Tuberculosis and Lung Disease
SETTING: The optimal timing of screening for diabetes mellitus (DM) among tuberculosis (TB) cases is unclear due to the possibility of stress hyperglycemia. DESIGN: We evaluated adult (18 years) pulmonary TB cases at treatment initiation as well as at 3 months,...

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World AIDS Day 2016 at BJGMC

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2016-12-06
Read more about 2016 World AIDS Day activities at the BJGMC Clinical Site in Pune, India.

CCGHE at ID Week 2016

Post Date: 
2016-10-11
OCTOBER 27 TB Infection Prevalence, Incidence and Risk Factors among Child and Adult Household Contacts of Adult TB Cases in India Shivakumar SVBY, Chandrasekaran P, Thiruvengadam K, Gupte N, Mave V, Hannah LE, Kulkarni V, Gupte A, Deluca A, Gomathy NS, Sathyamurthi P, Paradkar M, Kohli R, Meshram...

Imec’s miDiagnostics joint venture does blood tests from blood-drop

Post Date: 
2016-08-09
Source: 
Electronics Weekly
miDiagnostics, the joint venture between Imec and Johns Hopkins University, aims to develop IC-based diagnostic tests which use drops of blood to detect cells, proteins, nucleic acids, and/or small molecules.

emocha’s public health apps are heading to California

Post Date: 
2016-08-02
Source: 
Technical.ly Baltimore
Three counties in California signed on to use emocha’s apps for managing tuberculosis. The Johns Hopkins spinout is implementing miDOT in Fresno, Merced and Contra Costa counties.

Help on wheels to screen TB in rural areas

Post Date: 
2016-07-26
Source: 
The Times of India
A state-of the art health services bus would provide medical care to rural populace at their doorsteps. Designed through a donation of US$100,000 from philanthropists Raj and Bharati Shah of the US-based Capital Technology Information Services (CTIS), the...

Mobile Health and Wellness Clinic Debuts in Pune for Clinical Research and Community-Based Care

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2016-07-25
The Maryland-based health care informatics company CTIS and its founders, Raj and Bharti Shah, have collaborated with the Johns Hopkins Center for Clinical Global Health Education and Byramjee Jeejeebhoy Government Medical College to equip and dispatch a custom-designed mobile health care services...

CCGHE at AIDS 2016

Post Date: 
2016-07-20
CCGHE efforts presented at AIDS 2016 in Durban, South Africa

2016 Global Health Established Field Placement Awardees

Post Date: 
2016-06-28
The following Johns Hopkins students received Global Health Established Field Placement Awards to work on CCGHE research studies in India and Uganda. Each student is spending a minimum of 6 weeks in the field, and each has been awarded $3500 from the Johns Hopkins Center for Global Health for...

Confronting Gender Based Violence 2016 Course

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2016-06-16
2016-06-16—The Johns Hopkins Center for Clinical Global Health Education (CCGHE) is pleased to launch the free online course Confronting Gender-based Violence: Global Lessons for Healthcare Workers. Registration is now open for the course, which is being offered through...

Up Close: Jessica Elf

Post Date: 
2016-05-31
The quality of air is an ethical imperative.

Amita Gupta Appointed US Chair for India TB Research Consortium

Post Date: 
2016-05-11
“After more than 40 years of little discovery, interest, or funding for TB research, we are at a nexus of advancement."

Can Technology & Training Promote Retention in Care & Prevent HIV Transmission?

Post Date: 
2016-05-10
When HIV+ mothers are actively engaged in care, they are far less likely to transmit the disease to their babies. And while HIV+ women in India generally seek initial care, maintaining continuity of care can be challenging. One study in India seeks to answer the question: Can a focused...

Study evaluates four-drug TB treatment for HIV/AIDS patients

Post Date: 
2016-04-04
Source: 
Vaccine News Daily
"Our results even suggest the four-drug strategy is actually doing more harm than isoniazid-alone therapy because study participants found it less tolerable and stopped using it," Dr. Amita Gupta, senior study author and associate professor of medicine and deputy director of the Johns Hopkins...

Feasibility Study Complete on Preventive Therapy for Household Contacts of MDR-TB Patients in Pune, India

Post Date: 
2016-03-31
March 31, 2016—Pune, India—The Baltimore-Washington-India Clinical Trials Unit is pleased to announce that the BJGMC Clinical Research Site (BJGMC-CRS) in Pune, India, just finished the feasibility study titled A5300/IMPAACT2003: Study of MDR-TB Cases and their Household Contacts: Operational...

In Many Regions, World Tuberculosis Day is Every Day

Post Date: 
2016-03-24
India Assumes the Greatest Burden Each year on March 24, the world pauses to reflect on the devastation that tuberculosis causes globally. TB is preventable and treatable, and it disproportionately and gravely affects resource-limited regions of the world. The World Health Organization reports that...

Proactively treating HIV patients at risk for tuberculosis with multi-drug TB regimens doesn't save more lives

Post Date: 
2016-03-20
Source: 
Health Canal
The number one killer of HIV patients in resource-limited areas, including parts of Africa and India, is tuberculosis (TB), underscoring the need for optimal treatments and effective strategies to address this deadly co-infection. But TB is harder to detect in HIV-infected patients and...

Multidrug TB prophylaxis not needed in advanced HIV

Post Date: 
2016-03-18
Source: 
MedPage Today
Patients with advanced HIV infection initiating anti-retroviral therapy who were treated with isoniazid alone to prevent tuberculosis had similar survival rates as patients treated with a standard four-drug anti-tuberculosis regimen in a multi-national, randomized, controlled trial.

Proactively treating HIV patients at risk for tuberculosis with multi-drug TB regimens doesn't save more lives

Post Date: 
2016-03-18
Source: 
Infection Control Today
In what investigators say is a surprise finding, results of a new study appear to strongly affirm the effectiveness of prescribing the anti-tuberculosis drug isoniazid alone — in place of the standard four-drug regimen — to prevent TB and reduce death in

Common TB treatment in HIV: no added benefit?

Post Date: 
2016-03-18
Source: 
Pharmaceutical Processing Online
In a report on the REMEMBER (Reducing Early Mortality and Early Morbidity by Empiric Tuberculosis Treatment) study—a 10-nation, randomized clinical trial of adult outpatients—investigators concluded that there was no added benefit of using four drugs for TB over just using one drug, isoniazid...

4-drug tuberculosis treatment among HIV/AIDS patients does not save more lives

Post Date: 
2016-03-18
Source: 
MedIndia
There was no added benefit of using four drugs for tuberculosis over using just one drug, isoniazid, to save lives in people with advanced HIV/AIDS, revealed a report on the so-called REMEMBER (Reducing Early Mortality and Early Morbidity by Empiric Tuberculosis Treatment) study—a 10 nation,...

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